Adgrb1 adhesion G protein-coupled receptor B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrb1provided by MGI
Official Full Name: adhesion G protein-coupled receptor B1provided by MGI
Primary source: MGI:MGI:1933736
See related: Ensembl:ENSMUSG00000034730 AllianceGenome:MGI:1933736
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bai1; mKIAA4089; B830018M07Rik
Summary: Enables several functions, including PDZ domain binding activity; lipopolysaccharide binding activity; and phosphatidylserine binding activity. Involved in several processes, including negative regulation of protein metabolic process; phagocytosis; and positive regulation of myoblast fusion. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including focal adhesion; phagocytic cup; and postsynaptic density. Is expressed in several structures, including brain and reproductive system. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human ADGRB1 (adhesion G protein-coupled receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 63.8), frontal lobe adult (RPKM 61.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.22 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74388045..74461314)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74516196..74589465)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development.
Title: Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development.
LncRNA embryonic stem cells expressed 1 (Lncenc1) is identified as a novel regulator in neuropathic pain by interacting with EZH2 and downregulating the expression of Bai1 in mouse microglia.
Title: LncRNA embryonic stem cells expressed 1 (Lncenc1) is identified as a novel regulator in neuropathic pain by interacting with EZH2 and downregulating the expression of Bai1 in mouse microglia.
Rather, BAI1 associates with the Rho-GTPase regulatory protein Bcr late in development and stimulates its cryptic RhoA-GEF activity, which functions together with its Rac1-GAP activity to terminate dendritic arborization.
Title: The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
Study demonstrated that an evolutionarily conserved fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of the ELMO family scaffolds. The crystal structures of ELMO2-RAE and its complex with BAI1 uncover the molecular basis of BAI/ELMO interactions.
Title: Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds.
these findings suggest that BAI1 mediates the clearance of Gram-negative bacteria by stimulating both phagocytosis and NADPH oxidase activation, thereby coupling bacterial detection to the cellular microbicidal machinery.
Title: The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria.
transgenic mice overexpressing BAI1 had fewer apoptotic cells, reduced inflammation, and attenuated disease. Boosting BAI1-mediated uptake by intestinal epithelial cells was important in attenuating inflammation.
Title: Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo.
BAI1(-) mice have deficits in hippocampus-dependent spatial learning and memory, enhanced long-term potentiation, impaired long-term depression, and postsynaptic density thinning. BAI1 stops PSD-95 polyubiquitination/degradation via interaction with MDM2.
Title: BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.
data identify apoptotic cells as a new type of cue that induces signalling via the phosphatidylserine receptor BAI1 to promote fusion of healthy myoblasts, with important implications for muscle development and repair
Title: Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion.
expression pattern in brain regions and role as anti-angiogenic factor in mature neuropil
Title: Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor.
findings identify BAI1 as a pattern recognition receptor that mediates nonopsonic phagocytosis of Gram-negative bacteria by macrophages and directly affects the host response to infection
Title: Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa54d6.seq (e-PCR)
- UniSTS:125215

MDB1006 (e-PCR)
- UniSTS:125042

Bai1 (e-PCR), detects polymorphism
- UniSTS:532661

RH125160 (e-PCR)
- UniSTS:161982

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in engulfment of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in engulfment of apoptotic cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor B1

Names: brain-specific angiogenesis inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359759.1 → NP_001346688.1 adhesion G protein-coupled receptor B1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC117657, AC118022

Conserved Domains (3) summary

smart00303
Location:237 → 295

GPS; G-protein-coupled receptor proteolytic site domain

pfam16489
Location:18 → 216

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd15251
Location:302 → 558

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors
NM_174991.3 → NP_778156.2 adhesion G protein-coupled receptor B1 isoform 1 precursor

See identical proteins and their annotated locations for NP_778156.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK147456, AK147459, DN176509

Consensus CDS

CCDS70635.1

UniProtKB/Swiss-Prot

Q3UH36, Q3UHD1, Q8CGM0

Related

ENSMUSP00000046097.10, ENSMUST00000042035.16

Conserved Domains (5) summary

smart00303
Location:880 → 938

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

pfam00002
Location:946 → 1180

7tm_2; 7 transmembrane receptor (Secretin family)

pfam16489
Location:662 → 857

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

74388045..74461314

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520271.4 → XP_006520334.1 adhesion G protein-coupled receptor B1 isoform X3

Conserved Domains (5) summary

smart00303
Location:877 → 935

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:574 → 640

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd15251
Location:942 → 1231

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:658 → 856

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_030248268.2 → XP_030104128.1 adhesion G protein-coupled receptor B1 isoform X6

Conserved Domains (5) summary

smart00303
Location:877 → 935

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:574 → 640

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd15251
Location:942 → 1198

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:658 → 856

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_006520269.3 → XP_006520332.1 adhesion G protein-coupled receptor B1 isoform X1

Conserved Domains (5) summary

smart00303
Location:880 → 938

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd15251
Location:945 → 1234

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:661 → 859

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_011245403.2 → XP_011243705.1 adhesion G protein-coupled receptor B1 isoform X4

Conserved Domains (5) summary

smart00303
Location:880 → 938

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd15251
Location:945 → 1234

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:661 → 859

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_011245404.2 → XP_011243706.1 adhesion G protein-coupled receptor B1 isoform X5

Conserved Domains (5) summary

smart00303
Location:880 → 938

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd15251
Location:945 → 1201

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:661 → 859

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_011245405.2 → XP_011243707.1 adhesion G protein-coupled receptor B1 isoform X7

Conserved Domains (6) summary

smart00303
Location:880 → 938

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd14964
Location:975 → 999

7tm_GPCRs; TM helix 6 [structural motif]

pfam16489
Location:661 → 859

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl28897
Location:975 → 1048

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_030248271.1 → XP_030104131.1 adhesion G protein-coupled receptor B1 isoform X8

Conserved Domains (6) summary

smart00303
Location:880 → 938

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd14964
Location:975 → 999

7tm_GPCRs; TM helix 6 [structural motif]

pfam16489
Location:661 → 859

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl28897
Location:975 → 1048

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006520270.3 → XP_006520333.1 adhesion G protein-coupled receptor B1 isoform X2

Conserved Domains (5) summary

smart00303
Location:879 → 937

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd15251
Location:944 → 1233

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:661 → 858

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_011245406.4 → XP_011243708.1 adhesion G protein-coupled receptor B1 isoform X9

UniProtKB/TrEMBL

A0A087WQV8

Conserved Domains (6) summary

smart00303
Location:880 → 938

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:577 → 643

HormR; Domain present in hormone receptors

smart00209
Location:412 → 462

TSP1; Thrombospondin type 1 repeats

cd14964
Location:946 → 971

7tm_GPCRs; TM helix 1 [structural motif]

pfam16489
Location:661 → 859

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl28897
Location:945 → 1126

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily