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Scamp1 secretory carrier membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 107767, updated on 5-Mar-2024

Summary

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Official Symbol
Scamp1provided by MGI
Official Full Name
secretory carrier membrane protein 1provided by MGI
Primary source
MGI:MGI:1349480
See related
Ensembl:ENSMUSG00000021687 AllianceGenome:MGI:1349480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930505M11Rik
Summary
Predicted to enable protein domain specific binding activity. Acts upstream of or within exocytosis. Located in synaptic vesicle membrane and zymogen granule membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SCAMP1 (secretory carrier membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 34.4), CNS E18 (RPKM 30.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C3; 13 49.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (94337818..94422339, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (94201310..94285831, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytochrome c, pseudogene 3 Neighboring gene lipoma HMGIC fusion partner-like 2 Neighboring gene predicted gene, 57596 Neighboring gene STARR-seq mESC enhancer starr_35303 Neighboring gene predicted gene, 32089 Neighboring gene nucleoside diphosphate kinase B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice. Fernández-Chacón R, et al. J Biol Chem, 1999 Nov 12. PMID 10551807
  2. Interaction assays in yeast and cultured cells confirm known and identify novel partners of the synaptic vesicle protein synaptophysin. Felkl M, et al. Neuroscience, 2008 Oct 2. PMID 18706977
  3. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Riedel D, et al. Mol Cell Biol, 2002 Sep. PMID 12192047, Free PMC Article
  4. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Bose A, et al. Nature, 2002 Dec 19-26. PMID 12490950
  5. Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation. Toonen RF, et al. J Neurochem, 2005 Jun. PMID 15935055

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle TAS
Traceable Author Statement
more info
 PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in zymogen granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secretory carrier-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346609.1 → NP_001333538.1  secretory carrier-associated membrane protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC148334, AK135058, AK162168
    Consensus CDS
    CCDS84049.1
    UniProtKB/TrEMBL
    Q3TSA8, Q9D577
    Related
    ENSMUSP00000123135.2, ENSMUST00000152555.8
    Conserved Domains (2) summary
    pfam04144
    Location:65 → 240
    SCAMP; SCAMP family
    cl03075
    Location:13 → 63
    GrpE; nucleotide exchange factor GrpE

  2. NM_029153.1 → NP_083429.1  secretory carrier-associated membrane protein 1 isoform 1

    See identical proteins and their annotated locations for NP_083429.1

    Status: VALIDATED

    Source sequence(s)
    BC034283
    Consensus CDS
    CCDS36750.1
    UniProtKB/Swiss-Prot
    Q8K021
    UniProtKB/TrEMBL
    Q3TD71, Q3UY11
    Related
    ENSMUSP00000022197.9, ENSMUST00000022197.15
    Conserved Domains (1) summary
    pfam04144
    Location:117 → 292
    SCAMP; SCAMP family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    94337818..94422339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247117.1 → XP_030102977.1  secretory carrier-associated membrane protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TSA8, Q9D577
    Conserved Domains (2) summary
    pfam04144
    Location:65 → 240
    SCAMP; SCAMP family
    cl03075
    Location:13 → 63
    GrpE; nucleotide exchange factor GrpE

  2. XM_030247116.1 → XP_030102976.1  secretory carrier-associated membrane protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TSA8, Q9D577
    Conserved Domains (2) summary
    pfam04144
    Location:65 → 240
    SCAMP; SCAMP family
    cl03075
    Location:13 → 63
    GrpE; nucleotide exchange factor GrpE

  3. XM_006517515.3 → XP_006517578.1  secretory carrier-associated membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006517578.1

    UniProtKB/TrEMBL
    Q3TSA8, Q9D577
    Related
    ENSMUSP00000120053.2, ENSMUST00000153558.8
    Conserved Domains (2) summary
    pfam04144
    Location:65 → 240
    SCAMP; SCAMP family
    cl03075
    Location:13 → 63
    GrpE; nucleotide exchange factor GrpE
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K021.1 GenPept UniProtKB/Swiss-Prot:Q8K021

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