U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rdh1 retinol dehydrogenase 1 (all trans) [ Mus musculus (house mouse) ]

Gene ID: 107605, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Rdh1provided by MGI
Official Full Name
retinol dehydrogenase 1 (all trans)provided by MGI
Primary source
MGI:MGI:1195275
See related
Ensembl:ENSMUSG00000089789 AllianceGenome:MGI:1195275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables NAD-retinol dehydrogenase activity and steroid dehydrogenase activity. Acts upstream of or within retinoid metabolic process and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of organelle membrane. Is expressed in several structures, including Rathke's pouch; central nervous system; genitourinary system; liver; and lung. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 10.7), liver E18 (RPKM 2.1) and 4 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 D3; 10 75.21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127595595..127604168)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127759726..127768299)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_28236 Neighboring gene G protein-coupled receptor 182 Neighboring gene STARR-seq mESC enhancer starr_28237 Neighboring gene retinol dehydrogenase 9 Neighboring gene retinol dehydrogenase 16 Neighboring gene STARR-seq mESC enhancer starr_28238

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular characterization of a mouse short chain dehydrogenase/reductase active with all-trans-retinol in intact cells, mRDH1. Zhang M, et al. J Biol Chem, 2001 Nov 23. PMID 11562362
  2. RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding. Krois CR, et al. Cell Mol Life Sci, 2019 Jun. PMID 30788515, Free PMC Article
  3. Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1. Zhang M, et al. J Biol Chem, 2004 Dec 3. PMID 15355969
  4. Gene structure and minimal promoter of mouse rdh1. Zhang M, et al. Gene, 2003 Feb 13. PMID 12594048
  5. Cloning and structural analysis of the murine GCN5L1 gene. Driessen CA, et al. Gene, 1997 Dec 5. PMID 9426003

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rdh1-generated all-trans-retinoic acid in brown adipose tissue regulates multiple genes that promote brown adipose tissue adaptation to whole-body energy status, such as fasting and re-feeding.
    Title: RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding.
  2. Altered vitamin A homeostasis and increased size and adiposity is associated with rdh1-null mouse
    Title: Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse.
  3. Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share similar N-terminal signaling sequences such as human Rdh5 and mouse Rdh4, orient with their catalytic domains facing the cytoplasm
    Title: Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within steroid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
retinol dehydrogenase 16
Names
retinol dehydrogenase 1 (11-cis)
NP_536684.2
XP_006513093.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080436.3 → NP_536684.2  retinol dehydrogenase 16 precursor

    See identical proteins and their annotated locations for NP_536684.2

    Status: VALIDATED

    Source sequence(s)
    AC129576, AK136574, AY028928
    Consensus CDS
    CCDS24250.1
    UniProtKB/TrEMBL
    Q8CGV4, Q8VIJ7
    Related
    ENSMUSP00000073322.6, ENSMUST00000073639.6
    Conserved Domains (2) summary
    cd09805
    Location:30 → 306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:30 → 211
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127595595..127604168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513030.5 → XP_006513093.1  retinol dehydrogenase 16 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:30 → 193
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous