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CHL1 cell adhesion molecule L1 like [ Homo sapiens (human) ]

Gene ID: 10752, updated on 3-Apr-2024

Summary

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Official Symbol
CHL1provided by HGNC
Official Full Name
cell adhesion molecule L1 likeprovided by HGNC
Primary source
HGNC:HGNC:1939
See related
Ensembl:ENSG00000134121 MIM:607416; AllianceGenome:HGNC:1939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CALL; L1CAM2
Summary
The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011]
Expression
Biased expression in brain (RPKM 21.7), ovary (RPKM 3.5) and 12 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3p26.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196763..409417)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188582..401277)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (238446..451100)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986057 Neighboring gene uncharacterized LOC124909336 Neighboring gene CHL1 antisense RNA 2 Neighboring gene FOXA motif-containing MPRA enhancer 226 Neighboring gene RNA, U6 small nuclear 1194, pseudogene Neighboring gene ribosomal protein S8 pseudogene 6 Neighboring gene CHL1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:492506-493034 Neighboring gene uncharacterized LOC105376922 Neighboring gene uncharacterized LOC124909337

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis. Qin M, et al. Appl Immunohistochem Mol Morphol, 2022 Mar 1. PMID 35262525
  2. Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism. Chen Y, et al. J Endocrinol Invest, 2021 Aug. PMID 33453020
  3. Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1. Yoo M, et al. Int J Neurosci, 2022 May. PMID 33054469
  4. Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell Function. Taneera J, et al. Exp Clin Endocrinol Diabetes, 2021 Dec. PMID 31614370
  5. Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC). Hötzel J, et al. J Cancer Res Clin Oncol, 2019 Sep. PMID 31372722

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1.
    Title: Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1.
  2. Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis.
    Title: Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis.
  3. Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of beta-cell Function.
    Title: Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell Function.
  4. Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.
    Title: Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.
  5. Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism.
    Title: Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism.
  6. Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.
    Title: Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.
  7. Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.
    Title: Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.
  8. CHL1 expression levels were significantly higher in ovarian endometriosis tissue than in eutopic endometrium.
    Title: Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis.
  9. The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination.
    Title: Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC).
  10. Results identified a new tumor suppressor, CHL1, located at 3p26 which was frequently deleted in esophageal squamous cells carcinoma (ESCC). Reduced expression of CHL1 correlated with poor differentiation, increased invasion, lymph-node metastasis, advanced tumor stage, and decreased overall survival. Further data support CHL1 as an important tumor suppressor with both anti-proliferation and anti-metastasis abilities.
    Title: Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2023-12-12)

ClinGen Genome Curation PagePubMed
Haploinsufficency

No evidence available (Last evaluated 2023-12-12)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
EBI GWAS Catalog
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.
EBI GWAS Catalog
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30674, FLJ44930, MGC132578, DKFZp547L174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protease binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cognition IEA
Inferred from Electronic Annotation
more info
  
involved_in exploration behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neural cell adhesion molecule L1-like protein
Names
L1 cell adhesion molecule 2
cell adhesion molecule with homology to L1CAM (close homolog of L1)
cell adhesion molecule with homology to L1CAM (close homologue of L1)
close homolog of L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253387.2 → NP_001240316.1  neural cell adhesion molecule L1-like protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001240316.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AB209329, AC011609, DA778898, R40400
    Consensus CDS
    CCDS58812.1
    UniProtKB/Swiss-Prot
    B7ZL03, O00533, Q2M3G2, Q59FY0
    UniProtKB/TrEMBL
    B3KX75
    Related
    ENSP00000380628.2, ENST00000397491.6
    Conserved Domains (9) summary
    cd00096
    Location:532 → 600
    Ig; Immunoglobulin domain
    cd04978
    Location:345 → 419
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:258 → 328
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:248 → 327
    IG_like; Immunoglobulin like
    cd00063
    Location:612 → 701
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:715 → 795
    fn3; Fibronectin type III domain
    pfam13882
    Location:1104 → 1189
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  2. NM_001253388.1 → NP_001240317.1  neural cell adhesion molecule L1-like protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001240317.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC011609, AC026187, BC143498, R40400
    Consensus CDS
    CCDS74887.1
    UniProtKB/TrEMBL
    A0A087X0M8, B3KX75
    Related
    ENSP00000483512.1, ENST00000620033.4
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1067 → 1152
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  3. NM_006614.4 → NP_006605.2  neural cell adhesion molecule L1-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_006605.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC011609, AC066595, AF002246, DA778898, R40400
    Consensus CDS
    CCDS2556.1
    UniProtKB/TrEMBL
    B3KX75
    Related
    ENSP00000256509.2, ENST00000256509.7
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1120 → 1205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

RNA

  1. NR_045572.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks the exons that contain the coding region in variant 1.
    Source sequence(s)
    AC026187, AC066595, AK055236, AL359583
    Related
    ENST00000489224.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    196763..409417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005566.2 → XP_016861055.1  neural cell adhesion molecule L1-like protein isoform X1

    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1120 → 1205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  2. XM_017005572.2 → XP_016861061.1  neural cell adhesion molecule L1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A087X0M8, B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1067 → 1152
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  3. XM_006712939.4 → XP_006713002.1  neural cell adhesion molecule L1-like protein isoform X1

    See identical proteins and their annotated locations for XP_006713002.1

    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1120 → 1205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  4. XM_017005573.2 → XP_016861062.1  neural cell adhesion molecule L1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A087X0M8, B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1067 → 1152
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  5. XM_017005569.2 → XP_016861058.1  neural cell adhesion molecule L1-like protein isoform X2

    UniProtKB/Swiss-Prot
    B7ZL03, O00533, Q2M3G2, Q59FY0
    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:532 → 600
    Ig; Immunoglobulin domain
    cd04978
    Location:345 → 419
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:258 → 328
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:248 → 327
    IG_like; Immunoglobulin like
    cd00063
    Location:612 → 701
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:715 → 795
    fn3; Fibronectin type III domain
    pfam13882
    Location:1104 → 1189
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  6. XM_006712938.2 → XP_006713001.1  neural cell adhesion molecule L1-like protein isoform X1

    See identical proteins and their annotated locations for XP_006713001.1

    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1120 → 1205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  7. XM_011533296.2 → XP_011531598.1  neural cell adhesion molecule L1-like protein isoform X3

    See identical proteins and their annotated locations for XP_011531598.1

    UniProtKB/TrEMBL
    A0A087X0M8, B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1067 → 1152
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  8. XM_011533294.2 → XP_011531596.1  neural cell adhesion molecule L1-like protein isoform X2

    See identical proteins and their annotated locations for XP_011531596.1

    UniProtKB/Swiss-Prot
    B7ZL03, O00533, Q2M3G2, Q59FY0
    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:532 → 600
    Ig; Immunoglobulin domain
    cd04978
    Location:345 → 419
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:258 → 328
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:248 → 327
    IG_like; Immunoglobulin like
    cd00063
    Location:612 → 701
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:715 → 795
    fn3; Fibronectin type III domain
    pfam13882
    Location:1104 → 1189
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  9. XM_017005567.2 → XP_016861056.1  neural cell adhesion molecule L1-like protein isoform X1

    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1120 → 1205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  10. XM_047447335.1 → XP_047303291.1  neural cell adhesion molecule L1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A087X0M8

  11. XM_017005571.2 → XP_016861060.1  neural cell adhesion molecule L1-like protein isoform X2

    UniProtKB/Swiss-Prot
    B7ZL03, O00533, Q2M3G2, Q59FY0
    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:532 → 600
    Ig; Immunoglobulin domain
    cd04978
    Location:345 → 419
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:258 → 328
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:248 → 327
    IG_like; Immunoglobulin like
    cd00063
    Location:612 → 701
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:715 → 795
    fn3; Fibronectin type III domain
    pfam13882
    Location:1104 → 1189
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  12. XM_011533292.2 → XP_011531594.1  neural cell adhesion molecule L1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011531594.1

    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1120 → 1205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  13. XM_011533295.2 → XP_011531597.1  neural cell adhesion molecule L1-like protein isoform X2

    See identical proteins and their annotated locations for XP_011531597.1

    UniProtKB/Swiss-Prot
    B7ZL03, O00533, Q2M3G2, Q59FY0
    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:532 → 600
    Ig; Immunoglobulin domain
    cd04978
    Location:345 → 419
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:258 → 328
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:248 → 327
    IG_like; Immunoglobulin like
    cd00063
    Location:612 → 701
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:715 → 795
    fn3; Fibronectin type III domain
    pfam13882
    Location:1104 → 1189
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  14. XM_006712940.4 → XP_006713003.1  neural cell adhesion molecule L1-like protein isoform X1

    See identical proteins and their annotated locations for XP_006713003.1

    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:548 → 616
    Ig; Immunoglobulin domain
    cd04978
    Location:361 → 435
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:274 → 344
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:264 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:628 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:731 → 811
    fn3; Fibronectin type III domain
    pfam13882
    Location:1120 → 1205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

  15. XM_017005570.2 → XP_016861059.1  neural cell adhesion molecule L1-like protein isoform X2

    UniProtKB/Swiss-Prot
    B7ZL03, O00533, Q2M3G2, Q59FY0
    UniProtKB/TrEMBL
    B3KX75
    Conserved Domains (9) summary
    cd00096
    Location:532 → 600
    Ig; Immunoglobulin domain
    cd04978
    Location:345 → 419
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05731
    Location:258 → 328
    Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
    cd05845
    Location:129 → 223
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:248 → 327
    IG_like; Immunoglobulin like
    cd00063
    Location:612 → 701
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:715 → 795
    fn3; Fibronectin type III domain
    pfam13882
    Location:1104 → 1189
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:55 → 126
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    188582..401277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344997.1 → XP_054200972.1  neural cell adhesion molecule L1-like protein isoform X1

  2. XM_054345004.1 → XP_054200979.1  neural cell adhesion molecule L1-like protein isoform X3

  3. XM_054344993.1 → XP_054200968.1  neural cell adhesion molecule L1-like protein isoform X1

  4. XM_054345005.1 → XP_054200980.1  neural cell adhesion molecule L1-like protein isoform X3

  5. XM_054345000.1 → XP_054200975.1  neural cell adhesion molecule L1-like protein isoform X2

  6. XM_054344991.1 → XP_054200966.1  neural cell adhesion molecule L1-like protein isoform X1

  7. XM_054344999.1 → XP_054200974.1  neural cell adhesion molecule L1-like protein isoform X2

  8. XM_054344994.1 → XP_054200969.1  neural cell adhesion molecule L1-like protein isoform X1

  9. XM_054345002.1 → XP_054200977.1  neural cell adhesion molecule L1-like protein isoform X2

  10. XM_054345003.1 → XP_054200978.1  neural cell adhesion molecule L1-like protein isoform X3

  11. XM_054345007.1 → XP_054200982.1  neural cell adhesion molecule L1-like protein isoform X3

  12. XM_054344992.1 → XP_054200967.1  neural cell adhesion molecule L1-like protein isoform X1

  13. XM_054344998.1 → XP_054200973.1  neural cell adhesion molecule L1-like protein isoform X2

  14. XM_054344995.1 → XP_054200970.1  neural cell adhesion molecule L1-like protein isoform X1

  15. XM_054345001.1 → XP_054200976.1  neural cell adhesion molecule L1-like protein isoform X2

  16. XM_054344996.1 → XP_054200971.1  neural cell adhesion molecule L1-like protein isoform X1

  17. XM_054345006.1 → XP_054200981.1  neural cell adhesion molecule L1-like protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00533.4 GenPept UniProtKB/Swiss-Prot:O00533

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