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Unc5b unc-5 netrin receptor B [ Mus musculus (house mouse) ]

Gene ID: 107449, updated on 5-Mar-2024

Summary

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Official Symbol
Unc5bprovided by MGI
Official Full Name
unc-5 netrin receptor Bprovided by MGI
Primary source
MGI:MGI:894703
See related
Ensembl:ENSMUSG00000020099 AllianceGenome:MGI:894703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc5h2; A630020F16; D10Bwg0792e; 6330415E02Rik
Summary
Predicted to enable netrin receptor activity. Acts upstream of or within anterior/posterior axon guidance. Predicted to be located in membrane raft. Is expressed in several structures, including brain; forelimb; ganglia; limb bud; and sensory organ. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 21.1), colon adult (RPKM 20.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 31.52 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60598373..60667360, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60762594..60831581, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57560 Neighboring gene STARR-seq mESC enhancer starr_26811 Neighboring gene solute carrier family 29 (nucleoside transporters), member 3 Neighboring gene STARR-seq mESC enhancer starr_26812 Neighboring gene STARR-positive B cell enhancer ABC_E2326 Neighboring gene STARR-positive B cell enhancer ABC_E2939 Neighboring gene VISTA enhancer mm1663 Neighboring gene STARR-seq mESC enhancer starr_26820 Neighboring gene predicted gene, 36750 Neighboring gene microRNA 6408

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Dudok B, et al. Neuron, 2021 Dec 1. PMID 34648750, Free PMC Article
  2. Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice. Ranganathan P, et al. Am J Nephrol, 2015. PMID 25896231, Free PMC Article
  3. UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis. Ranganathan P, et al. J Cell Mol Med, 2014 Jul. PMID 24720832, Free PMC Article
  4. UNC5B receptor deletion exacerbates tissue injury in response to AKI. Ranganathan P, et al. J Am Soc Nephrol, 2014 Feb. PMID 24115477, Free PMC Article
  5. The uncoordinated-5 homolog B (UNC5B) receptor increases myocardial ischemia-reperfusion injury. Köhler D, et al. PLoS One, 2013. PMID 23936025, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
    Title: Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
  2. GPC3-Unc5 receptor complex structure and role in cell migration.
    Title: GPC3-Unc5 receptor complex structure and role in cell migration.
  3. Endothelial Unc5B controls blood-brain barrier integrity.
    Title: Endothelial Unc5B controls blood-brain barrier integrity.
  4. Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
    Title: Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
  5. Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner.
    Title: Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner.
  6. Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
    Title: Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
  7. Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signaling.
    Title: Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.
  8. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.
    Title: Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10).
  9. fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.
    Title: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.
  10. Blockade of Netrin-1/Unc5b by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis
    Title: Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables netrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anterior/posterior axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
netrin receptor UNC5B
Names
protein unc-5 homolog 2
protein unc-5 homolog B
unc5 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359273.1 → NP_001346202.1  netrin receptor UNC5B isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK018177, AK147603, AW488068, BC048162
    Consensus CDS
    CCDS88011.1
    UniProtKB/TrEMBL
    Q3TYW6
    Related
    ENSMUSP00000151251.2, ENSMUST00000218637.2
    Conserved Domains (5) summary
    smart00218
    Location:530 → 633
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08802
    Location:847 → 930
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:249 → 300
    TSP1; Thrombospondin type 1 repeats
    pfam17217
    Location:680 → 819
    UPA; UPA domain
    cl11960
    Location:157 → 243
    Ig; Immunoglobulin domain

  2. NM_029770.3 → NP_084046.2  netrin receptor UNC5B isoform 1 precursor

    See identical proteins and their annotated locations for NP_084046.2

    Status: VALIDATED

    Source sequence(s)
    AK018177, AK147603, AK158284, AW488068, BC048162
    Consensus CDS
    CCDS23872.1
    UniProtKB/Swiss-Prot
    Q3U4F2, Q6PFH0, Q80Y85, Q8K1S3, Q9D398
    UniProtKB/TrEMBL
    Q3TYW6
    Related
    ENSMUSP00000077080.6, ENSMUST00000077925.7
    Conserved Domains (5) summary
    smart00218
    Location:541 → 644
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08802
    Location:858 → 941
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:249 → 300
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:155 → 243
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:157 → 243
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    60598373..60667360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1S3.1 GenPept UniProtKB/Swiss-Prot:Q8K1S3

Gene LinkOut

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