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Brms1 breast cancer metastasis-suppressor 1 [ Mus musculus (house mouse) ]

Gene ID: 107392, updated on 5-Mar-2024

Summary

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Official Symbol
Brms1provided by MGI
Official Full Name
breast cancer metastasis-suppressor 1provided by MGI
Primary source
MGI:MGI:2388804
See related
Ensembl:ENSMUSG00000080268 AllianceGenome:MGI:2388804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable NF-kappaB binding activity and histone deacetylase binding activity. Predicted to be involved in several processes, including positive regulation of anoikis; positive regulation of protein deacetylation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Sin3-type complex. Is expressed in alimentary system; central nervous system; genitourinary system; heart; and respiratory system. Orthologous to human BRMS1 (BRMS1 transcriptional repressor and anoikis regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 61.2), stomach adult (RPKM 31.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.23 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5091391..5099940)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5041363..5049912)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30581 Neighboring gene nuclear encoded tRNA serine 6 (anticodon GCT) Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5041192-5041379 Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene Ras and Rab interactor 1 Neighboring gene CD248 antigen, endosialin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis. Cook LM, et al. Clin Exp Metastasis, 2012 Apr. PMID 22241150, Free PMC Article
  2. Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor. Rivera J, et al. PLoS One, 2009 Jul 30. PMID 19649328, Free PMC Article
  3. Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1). Samant RS, et al. Cancer Lett, 2006 Apr 28. PMID 15978719
  4. Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1. Park YG, et al. Mamm Genome, 2002 Jun. PMID 12115030
  5. Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Hunter KW, et al. Cancer Res, 2001 Dec 15. PMID 11751410

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Brms1 suppressed pulmonary metastasis and promoted apoptosis of tumor cells located in the lungs but not in the mammary glands.
    Title: Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.
  2. results show for the first time that BRMS1 contains both nuclear import and export signals enabling its nucleo-cytoplasmic shuttling
    Title: Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor.
  3. Comparative sequence analysis in eight inbred strains
    Title: Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1.
  4. BRMS1 may participate in transcriptional regulation via interaction with the mSin3.HDAC complex
    Title: Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: B4gat1

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of anoikis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
breast cancer metastasis-suppressor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374047.1 → NP_001360976.1  breast cancer metastasis-suppressor 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124502
    UniProtKB/Swiss-Prot
    Q99N20
    UniProtKB/TrEMBL
    Q547N0, Q8R5H5
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 178
    Sds3; Sds3-like

  2. NM_001374048.1 → NP_001360977.1  breast cancer metastasis-suppressor 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124502
    UniProtKB/TrEMBL
    Q8R5H5
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 178
    Sds3; Sds3-like

  3. NM_134155.3 → NP_598916.1  breast cancer metastasis-suppressor 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_598916.1

    Status: VALIDATED

    Source sequence(s)
    AC124502
    Consensus CDS
    CCDS50355.1
    UniProtKB/Swiss-Prot
    Q99N20
    UniProtKB/TrEMBL
    Q547N0, Q8R5H5
    Related
    ENSMUSP00000112266.3, ENSMUST00000116567.4
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 178
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5091391..5099940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N20.1 GenPept UniProtKB/Swiss-Prot:Q99N20

Gene LinkOut

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