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Exoc6 exocyst complex component 6 [ Mus musculus (house mouse) ]

Gene ID: 107371, updated on 21-Apr-2024

Summary

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Official Symbol
Exoc6provided by MGI
Official Full Name
exocyst complex component 6provided by MGI
Primary source
MGI:MGI:1351611
See related
Ensembl:ENSMUSG00000053799 AllianceGenome:MGI:1351611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hbd; Sec15; msec15; Sec15l1; C430002C19; 4833405E05Rik
Summary
Acts upstream of or within erythrocyte differentiation. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in central nervous system; dorsal root ganglion; foregut; genitourinary system; and liver lobe. Orthologous to human EXOC6 (exocyst complex component 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 12.6), liver E14 (RPKM 11.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C2; 19 32.32 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37525181..37672499)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37536763..37684052)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122C19 gene Neighboring gene predicted gene, 32294 Neighboring gene predicted gene, 41842 Neighboring gene STARR-seq mESC enhancer starr_46060 Neighboring gene STARR-seq mESC enhancer starr_46061 Neighboring gene STARR-seq mESC enhancer starr_46062 Neighboring gene predicted gene, 32342 Neighboring gene cytochrome P450, family 26, subfamily c, polypeptide 1 Neighboring gene cytochrome P450, family 26, subfamily a, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling. Zhang AS, et al. Exp Hematol, 2006 May. PMID 16647565
  2. B-cell deficiency and reduced B-cell reconstitution in hemoglobin-deficit mice. Lipovsky K, et al. Exp Hematol, 2003 Dec. PMID 14662329
  3. The hemoglobin-deficit mouse: cure of the anemia following bone marrow transplantation with normal marrow. Simon-Stoos KL, et al. Exp Hematol, 1999 Jan. PMID 9923455
  4. The hemoglobin-deficit mouse: analysis of phenotype and hematopoiesis in the transplant model. Bloom ML, et al. Blood, 1997 Sep 1. PMID 9292544
  5. [An additional house mouse mutant with anemia (hemoglobin deficiency)]. Scheufler H. Z Versuchstierkd, 1969. PMID 5405927

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that the association of Rab10-GTP with Exoc6/6b is a molecular link between insulin signaling and the exocytic machinery in GLUT4 translocation.
    Title: A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b.
  2. Exoc3l is involved in regulated exocytosis of insulin granules; expressed in insulin-secreting cells as well as in various tissues including pancreatic islets and brain.
    Title: Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion.
  3. These data indicate that rapid transferrin recycling is defective after pSec15l1 has mutated.
    Title: Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd mice.
  4. Iron metabolism mutant hbd mice have an exon deletion in Sec15l1.
    Title: Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking.
  5. Mutation in Sec15l1 causes anemia in hemoglobin deficit mice.
    Title: A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice.
Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description Tests
hemoglobin deficient
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
exocyst complex component 6
Names
SEC15 homolog
SEC15-like 1
SEC15-like protein 1
exocyst complex component Sec15A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175353.2 → NP_780562.2  exocyst complex component 6

    See identical proteins and their annotated locations for NP_780562.2

    Status: VALIDATED

    Source sequence(s)
    AC110212, AK076455, AK082881, BY100185, CD806857
    Consensus CDS
    CCDS29779.1
    UniProtKB/TrEMBL
    A0A5F8MPW8, Q3U9D6
    Related
    ENSMUSP00000064332.7, ENSMUST00000066439.8
    Conserved Domains (1) summary
    pfam04091
    Location:456 → 762
    Sec15; Exocyst complex subunit Sec15-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    37525181..37672499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318044.2 → XP_017173533.1  exocyst complex component 6 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MP92, A0A5F8MPW8
    Related
    ENSMUSP00000158866.2, ENSMUST00000238954.2
    Conserved Domains (1) summary
    pfam04091
    Location:463 → 769
    Sec15; Exocyst complex subunit Sec15-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R313.2 GenPept UniProtKB/Swiss-Prot:Q8R313

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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