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Kank1 KN motif and ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

Gene ID: 107351, updated on 3-Apr-2024

Summary

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Official Symbol
Kank1provided by MGI
Official Full Name
KN motif and ankyrin repeat domains 1provided by MGI
Primary source
MGI:MGI:2147707
See related
Ensembl:ENSMUSG00000032702 AllianceGenome:MGI:2147707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ankrd15; mKIAA0172; A930031B09Rik; D330024H06Rik
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including glomerular visceral epithelial cell migration; negative regulation of cellular component organization; and regulation of signal transduction. Predicted to be located in nucleus and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; limb; and metanephros. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 22.5), ovary adult (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 B; 19 20.33 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (25214146..25411861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (25236732..25434498)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 8 Neighboring gene STARR-seq mESC enhancer starr_45812 Neighboring gene predicted gene, 34186 Neighboring gene predicted gene, 24252 Neighboring gene STARR-seq mESC enhancer starr_45817 Neighboring gene STARR-seq mESC enhancer starr_45819 Neighboring gene predicted gene, 34432 Neighboring gene predicted gene, 52392 Neighboring gene STARR-seq mESC enhancer starr_45822 Neighboring gene predicted gene, 26207 Neighboring gene predicted gene 5249

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion. Pan W, et al. J Biol Chem, 2018 Feb 9. PMID 29217769, Free PMC Article
  2. Structural analyses of key features in the KANK1·KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex. Weng Z, et al. J Biol Chem, 2018 Jan 5. PMID 29158259, Free PMC Article
  3. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. Zhu Y, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996375
  4. Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. Kakinuma N, et al. J Cell Biol, 2008 May 5. PMID 18458160, Free PMC Article
  5. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins. Guo SS, et al. Exp Cell Res, 2021 Jan 1. PMID 33253712

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model.
    Title: Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model.
  2. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
    Title: Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
  3. KANK1 binds to KIF21A through ankyrin repeat.
    Title: Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion.
  4. Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1.
    Title: Structural analyses of key features in the KANK1·KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex.
  5. Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling.
    Title: Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC90826

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 1
Names
ankyrin repeat domain 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348180.2 → NP_001335109.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:1080 → 1246
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    pfam12796
    Location:1164 → 1249
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001404570.1 → NP_001391499.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238

  3. NM_001404572.1 → NP_001391501.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238

  4. NM_001404573.1 → NP_001391502.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238

  5. NM_001404574.1 → NP_001391503.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319

  6. NM_001404575.1 → NP_001391504.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238

  7. NM_001404576.1 → NP_001391505.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238

  8. NM_001404577.1 → NP_001391506.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319

  9. NM_001404578.1 → NP_001391507.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319

  10. NM_001404579.1 → NP_001391508.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319

  11. NM_001404580.1 → NP_001391509.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319

  12. NM_001404581.1 → NP_001391510.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126944

  13. NM_001404582.1 → NP_001391511.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC126944

  14. NM_001404583.1 → NP_001391512.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126944

  15. NM_001404584.1 → NP_001391513.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126944

  16. NM_001404585.1 → NP_001391514.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC126944

  17. NM_001404605.1 → NP_001391534.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC126944

  18. NM_001404607.1 → NP_001391536.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126944

  19. NM_001404608.1 → NP_001391537.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126944

  20. NM_001404610.1 → NP_001391539.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC126944

  21. NM_181404.7 → NP_852069.4  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_852069.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126944, AC132319
    Consensus CDS
    CCDS37944.1
    UniProtKB/TrEMBL
    E9Q238, Q6AXG6
    Related
    ENSMUSP00000042177.9, ENSMUST00000049400.15
    Conserved Domains (4) summary
    COG0666
    Location:1162 → 1328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1242 → 1272
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    pfam12796
    Location:1246 → 1331
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    25214146..25411861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526585.3 → XP_006526648.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006526648.1

    UniProtKB/TrEMBL
    E9Q238, Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:1162 → 1328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1242 → 1272
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    pfam12796
    Location:1246 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036161387.1 → XP_036017280.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9Q238, Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:1162 → 1328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1242 → 1272
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    pfam12796
    Location:1246 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_036161391.1 → XP_036017284.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:1080 → 1246
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:30 → 68
    KN_motif; KN motif
    pfam12796
    Location:1164 → 1249
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_030250693.2 → XP_030106553.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:1004 → 1170
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1084 → 1114
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:102 → 330
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:1088 → 1173
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_030250692.2 → XP_030106552.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:1004 → 1170
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1084 → 1114
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:102 → 330
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:1088 → 1173
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_006526590.3 → XP_006526653.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    E9Q944
    Related
    ENSMUSP00000116660.2, ENSMUST00000146647.3
    Conserved Domains (2) summary
    pfam00769
    Location:288 → 516
    ERM; Ezrin/radixin/moesin family
    pfam12075
    Location:58 → 96
    KN_motif; KN motif

  7. XM_006526586.5 → XP_006526649.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (5) summary
    COG0666
    Location:1108 → 1274
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1188 → 1218
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:288 → 516
    ERM; Ezrin/radixin/moesin family
    pfam12075
    Location:58 → 96
    KN_motif; KN motif
    pfam12796
    Location:1192 → 1277
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_004940110.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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