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Gbf1 golgi-specific brefeldin A-resistance factor 1 [ Mus musculus (house mouse) ]

Gene ID: 107338, updated on 21-Apr-2024

Summary

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Official Symbol
Gbf1provided by MGI
Official Full Name
golgi-specific brefeldin A-resistance factor 1provided by MGI
Primary source
MGI:MGI:1861607
See related
Ensembl:ENSMUSG00000025224 AllianceGenome:MGI:1861607
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0248; 1700083E03Rik
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and protein localization to organelle. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum lumen; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in brain; embryo; and head. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 37.5), duodenum adult (RPKM 22.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.75 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46140948..46274949)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46152509..46286510)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7666 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene STARR-positive B cell enhancer ABC_E11034 Neighboring gene STARR-positive B cell enhancer ABC_E101 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain transcription factor 3 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene STARR-seq mESC enhancer starr_46298 Neighboring gene STARR-positive B cell enhancer ABC_E11035 Neighboring gene STARR-seq mESC enhancer starr_46300 Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9457 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Neighboring gene pleckstrin and Sec7 domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulating the regulators: role of phosphorylation in modulating the function of the GBF1/BIG family of Sec7 ARF-GEFs. Walton K, et al. FEBS Lett, 2020 Jul. PMID 32333796
  2. The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor. García-Mata R, et al. EMBO Rep, 2003 Mar. PMID 12634853, Free PMC Article
  3. The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN). Lowery J, et al. J Biol Chem, 2013 Apr 19. PMID 23386609, Free PMC Article
  4. Development of monoclonal antibodies against GBF1 and their use in studying its functions. Roy SK, et al. J Interferon Cytokine Res, 2005 Nov. PMID 16318580
  5. Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice. Semina EV, et al. Hum Mol Genet, 2000 Jul 1. PMID 10861284

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulating the regulators: role of phosphorylation in modulating the function of the GBF1/BIG family of Sec7 ARF-GEFs.
    Title: Regulating the regulators: role of phosphorylation in modulating the function of the GBF1/BIG family of Sec7 ARF-GEFs.
  2. an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum.
    Title: The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
  3. novel interaction between p115 and Golgi-specific brefeldin-A-resistant factor 1 (GBF1)
    Title: The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor.
  4. GBF1 is recruited to the endogenous IRF-9 promoter, and interacts with C/EBP-beta, IL-1, and IL-6
    Title: Development of monoclonal antibodies against GBF1 and their use in studying its functions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90745, MGC100238

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum-Golgi intermediate compartment organization ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of monopolar cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Names
BFA-resistant GEF 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178930.3 → NP_849261.2  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

    See identical proteins and their annotated locations for NP_849261.2

    Status: PROVISIONAL

    Source sequence(s)
    BC076569
    Consensus CDS
    CCDS29873.1
    UniProtKB/Swiss-Prot
    Q6DFZ1
    UniProtKB/TrEMBL
    Q6A099
    Related
    ENSMUSP00000026254.8, ENSMUST00000026254.14
    Conserved Domains (2) summary
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain
    pfam12783
    Location:400 → 545
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46140948..46274949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526582.4 → XP_006526645.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

    UniProtKB/TrEMBL
    Q6A099
    Related
    ENSMUST00000176992.8
    Conserved Domains (4) summary
    PHA03247
    Location:1725 → 1855
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:483 → 1002
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain
    pfam12783
    Location:400 → 545
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  2. XM_006526580.4 → XP_006526643.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    Q6A099
    Conserved Domains (4) summary
    PHA03247
    Location:1730 → 1860
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:484 → 1003
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700 → 885
    Sec7; Sec7 domain
    pfam12783
    Location:401 → 546
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  3. XM_006526581.4 → XP_006526644.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    Q6A099
    Conserved Domains (4) summary
    PHA03247
    Location:1726 → 1856
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:484 → 1003
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700 → 885
    Sec7; Sec7 domain
    pfam12783
    Location:401 → 546
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  4. XM_006526583.3 → XP_006526646.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:979 → 1109
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:20 → 412
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:16 → 134
    Sec7; Sec7 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFZ1.1 GenPept UniProtKB/Swiss-Prot:Q6DFZ1

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