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Trpt1 tRNA phosphotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 107328, updated on 5-Mar-2024

Summary

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Official Symbol
Trpt1provided by MGI
Official Full Name
tRNA phosphotransferase 1provided by MGI
Primary source
MGI:MGI:1333115
See related
Ensembl:ENSMUSG00000047656 AllianceGenome:MGI:1333115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tpt1; Tpt1h; Gm35838
Summary
Enables tRNA 2'-phosphotransferase activity. Acts upstream of or within regulation of protein kinase activity and tRNA splicing, via endonucleolytic cleavage and ligation. Is expressed in several structures, including gonad; intestine; liver; lung; and spleen. Orthologous to human TRPT1 (tRNA phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 9.3), adrenal adult (RPKM 8.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19; 19 A
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6970046..6977689)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6996110..7000321)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1971 Neighboring gene predicted gene, 54053 Neighboring gene vascular endothelial growth factor B Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene nudix hydrolase 22 Neighboring gene fermitin family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052 Neighboring gene STARR-seq mESC enhancer starr_45447 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_45448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7140992-7141179 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene fibronectin leucine rich transmembrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. Harding HP, et al. RNA, 2008 Feb. PMID 18094117, Free PMC Article
  2. A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli. Spinelli SL, et al. Proc Natl Acad Sci U S A, 1998 Nov 24. PMID 9826666, Free PMC Article
  3. SAGE2Splice: unmapped SAGE tags reveal novel splice junctions. Kuo BY, et al. PLoS Comput Biol, 2006 Apr. PMID 16683015, Free PMC Article
  4. Spermatogonia-dependent expression of testicular genes in mice. Tanaka K, et al. Dev Biol, 2002 Jun 15. PMID 12051830
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
    Title: Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
  2. Inactivation of the Trpt1 gene, encoding the only known mammalian homolog of Tpt1p, eliminates all detectable 2'-phosphotransferase activity from cultured mouse cells but has no measurable effect on spliced Xbp-1 translation.
    Title: An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC41710

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tRNA 2'-phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA 2'-phosphotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA splicing, via endonucleolytic cleavage and ligation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tRNA 2'-phosphotransferase 1
Names
EST-MNCb3719
mTPT1
tRNA splicing 2' phosphotransferase 1 homolog
NP_705825.2
XP_006526640.1
XP_006526641.1
XP_006526642.1
XP_036017277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153597.2 → NP_705825.2  tRNA 2'-phosphotransferase 1

    See identical proteins and their annotated locations for NP_705825.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is protein-coding.
    Source sequence(s)
    AK038830, BC027575
    Consensus CDS
    CCDS50375.1
    UniProtKB/Swiss-Prot
    Q8K3A2
    Related
    ENSMUSP00000085555.6, ENSMUST00000088223.7
    Conserved Domains (1) summary
    pfam01885
    Location:21 → 198
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

RNA

  1. NR_027351.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK038830, BC027575
    Related
    ENSMUST00000237234.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6970046..6977689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161384.1 → XP_036017277.1  tRNA 2'-phosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8K3A2
    Conserved Domains (1) summary
    pfam01885
    Location:21 → 198
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  2. XM_006526578.5 → XP_006526641.1  tRNA 2'-phosphotransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam01885
    Location:26 → 180
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  3. XM_006526579.3 → XP_006526642.1  tRNA 2'-phosphotransferase 1 isoform X3

    Conserved Domains (1) summary
    cl19470
    Location:48 → 83
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  4. XM_006526577.5 → XP_006526640.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006526640.1

    UniProtKB/Swiss-Prot
    Q8K3A2
    Conserved Domains (1) summary
    pfam01885
    Location:21 → 198
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3A2.2 GenPept UniProtKB/Swiss-Prot:Q8K3A2

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