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Vps37c vacuolar protein sorting 37C [ Mus musculus (house mouse) ]

Gene ID: 107305, updated on 5-Mar-2024

Summary

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Official Symbol
Vps37cprovided by MGI
Official Full Name
vacuolar protein sorting 37Cprovided by MGI
Primary source
MGI:MGI:2147661
See related
Ensembl:ENSMUSG00000048832 AllianceGenome:MGI:2147661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730409F24Rik
Summary
Predicted to enable calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within protein transport. Predicted to be located in endosome and membrane. Predicted to be part of ESCRT I complex. Is expressed in glossopharyngeal ganglion; liver lobe; trigeminal ganglion; and vibrissa. Orthologous to human VPS37C (VPS37C subunit of ESCRT-I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 20.1), adrenal adult (RPKM 16.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 7.16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10666095..10691992)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10688735..10714628)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pepsinogen 5, group I Neighboring gene RIKEN cDNA 2210404E10 gene Neighboring gene CD5 antigen Neighboring gene RIKEN cDNA A430093F15 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 37C
Names
ESCRT-I complex subunit VPS37C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361958.1 → NP_001348887.1  vacuolar protein sorting-associated protein 37C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK158833, AK159309, BX635445
    Consensus CDS
    CCDS29585.1
    UniProtKB/Swiss-Prot
    Q3TY76, Q8R105
    Related
    ENSMUSP00000158500.2, ENSMUST00000235927.2
    Conserved Domains (2) summary
    PHA03247
    Location:184 → 313
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  2. NM_001361959.1 → NP_001348888.1  vacuolar protein sorting-associated protein 37C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK158833, BX635445
    Conserved Domains (2) summary
    PHA03247
    Location:76 → 205
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:2 → 41
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  3. NM_001361960.1 → NP_001348889.1  vacuolar protein sorting-associated protein 37C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK150606, AK158833, BX635445
    Consensus CDS
    CCDS89345.1
    UniProtKB/TrEMBL
    A0A494BAR3
    Related
    ENSMUSP00000158200.2, ENSMUST00000235921.2
    Conserved Domains (1) summary
    pfam07200
    Location:5 → 119
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  4. NM_001361961.1 → NP_001348890.1  vacuolar protein sorting-associated protein 37C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132247
    Consensus CDS
    CCDS29585.1
    UniProtKB/Swiss-Prot
    Q3TY76, Q8R105
    Conserved Domains (2) summary
    PHA03247
    Location:184 → 313
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  5. NM_001361962.1 → NP_001348891.1  vacuolar protein sorting-associated protein 37C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132247
    Consensus CDS
    CCDS29585.1
    UniProtKB/Swiss-Prot
    Q3TY76, Q8R105
    Conserved Domains (2) summary
    PHA03247
    Location:184 → 313
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  6. NM_001361963.1 → NP_001348892.1  vacuolar protein sorting-associated protein 37C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132247
    Conserved Domains (2) summary
    PHA03247
    Location:76 → 205
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:2 → 41
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  7. NM_001361964.1 → NP_001348893.1  vacuolar protein sorting-associated protein 37C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132247, AK159309, BX635445, CO426419
    Consensus CDS
    CCDS29585.1
    UniProtKB/Swiss-Prot
    Q3TY76, Q8R105
    Conserved Domains (2) summary
    PHA03247
    Location:184 → 313
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  8. NM_181403.3 → NP_852068.1  vacuolar protein sorting-associated protein 37C isoform 1

    See identical proteins and their annotated locations for NP_852068.1

    Status: VALIDATED

    Source sequence(s)
    AC132247
    Consensus CDS
    CCDS29585.1
    UniProtKB/Swiss-Prot
    Q3TY76, Q8R105
    Related
    ENSMUSP00000085264.6, ENSMUST00000087951.7
    Conserved Domains (2) summary
    PHA03247
    Location:184 → 313
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10666095..10691992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161381.1 → XP_036017274.1  vacuolar protein sorting-associated protein 37C isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:76 → 205
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:2 → 41
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  2. XM_036161382.1 → XP_036017275.1  vacuolar protein sorting-associated protein 37C isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:76 → 205
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:2 → 41
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  3. XM_006526574.5 → XP_006526637.1  vacuolar protein sorting-associated protein 37C isoform X1

    See identical proteins and their annotated locations for XP_006526637.1

    UniProtKB/Swiss-Prot
    Q3TY76, Q8R105
    Conserved Domains (2) summary
    PHA03247
    Location:184 → 313
    PHA03247; large tegument protein UL36; Provisional
    pfam07200
    Location:5 → 149
    Mod_r; Modifier of rudimentary (Mod(r)) protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R105.1 GenPept UniProtKB/Swiss-Prot:Q8R105

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