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Yars1 tyrosyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 107271, updated on 5-Mar-2024

Summary

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Official Symbol
Yars1provided by MGI
Official Full Name
tyrosyl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:2147627
See related
Ensembl:ENSMUSG00000028811 AllianceGenome:MGI:2147627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Yars
Summary
Predicted to enable tyrosine-tRNA ligase activity. Predicted to be involved in tyrosyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in cytosol and nuclear body. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.4), cerebellum adult (RPKM 19.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 63.05 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129083595..129113033)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129189734..129219240)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 5 Neighboring gene S100P binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3517 Neighboring gene STARR-seq mESC enhancer starr_11478 Neighboring gene STARR-seq mESC enhancer starr_11480 Neighboring gene NHS like 3 Neighboring gene STARR-seq mESC enhancer starr_11482 Neighboring gene predicted gene 12976 Neighboring gene STARR-positive B cell enhancer ABC_E7991 Neighboring gene syncoilin Neighboring gene retinoblastoma binding protein 4, chromatin remodeling factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Precision mouse models of Yars/dominant intermediate Charcot-Marie-Tooth disease type C and Sptlc1/hereditary sensory and autonomic neuropathy type 1. Hines TJ, et al. J Anat, 2022 Nov. PMID 34875719, Free PMC Article
  2. Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals. Tsukahara T, et al. Peptides, 2018 Mar. PMID 29289698
  3. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Wei N, et al. Mol Cell, 2014 Oct 23. PMID 25284223, Free PMC Article
  4. Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels. Sleigh JN, et al. Front Cell Neurosci, 2020. PMID 32848623, Free PMC Article
  5. The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy. Spaulding EL, et al. Science, 2021 Sep 3. PMID 34516839, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tyrosine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine--tRNA ligase, cytoplasmic
Names
tyrRS
tyrosyl--tRNA ligase
tyrosyl-tRNA synthetase, cytoplasmic
NP_598912.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134151.5 → NP_598912.5  tyrosine--tRNA ligase, cytoplasmic

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS18685.2
    UniProtKB/Swiss-Prot
    Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183, Q91WQ3
    UniProtKB/TrEMBL
    A2A7S7
    Related
    ENSMUSP00000101669.4, ENSMUST00000106054.4
    Conserved Domains (2) summary
    PLN02610
    Location:327 → 528
    PLN02610; probable methionyl-tRNA synthetase
    cl00015
    Location:8 → 328
    nt_trans; nucleotidyl transferase superfamily

RNA

  1. NR_160965.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606977

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129083595..129113033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_376292.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WQ3.3 GenPept UniProtKB/Swiss-Prot:Q91WQ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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