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Kazald1 Kazal-type serine peptidase inhibitor domain 1 [ Mus musculus (house mouse) ]

Gene ID: 107250, updated on 25-Apr-2024

Summary

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Official Symbol
Kazald1provided by MGI
Official Full Name
Kazal-type serine peptidase inhibitor domain 1provided by MGI
Primary source
MGI:MGI:2147606
See related
Ensembl:ENSMUSG00000025213 AllianceGenome:MGI:2147606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bono1; IGFBP-rP10
Summary
Predicted to enable insulin-like growth factor binding activity. Acts upstream of or within extracellular matrix organization. Located in interstitial matrix. Is expressed in several structures, including bone; cap mesenchyme; jaw; nose; and testis. Orthologous to human KAZALD1 (Kazal type serine peptidase inhibitor domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 22.4), ovary adult (RPKM 14.9) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45063404..45067728)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45074962..45079289)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45131818-45132020 Neighboring gene STARR-positive B cell enhancer ABC_E9175 Neighboring gene sideroflexin 3 Neighboring gene predicted gene, 35782 Neighboring gene STARR-seq mESC enhancer starr_46258 Neighboring gene STARR-seq mESC enhancer starr_46259 Neighboring gene predicted gene, 35867 Neighboring gene STARR-seq mESC enhancer starr_46262 Neighboring gene predicted gene, 35923

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells. Shibata Y, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555553
  2. Quantitative trait locus mapping of genes that control body length and plasma insulin-like growth factor 1 level in mice. Suto J. BMC Res Notes, 2012 Oct 2. PMID 23031221, Free PMC Article
  3. Bono1: a gene associated with regions of deposition of bone and dentine. James MJ, et al. Gene Expr Patterns, 2004 Sep. PMID 15261838
  4. Different roles of Runx2 during early neural crest-derived bone and tooth development. James MJ, et al. J Bone Miner Res, 2006 Jul. PMID 16813524
  5. Activin A Determines Steroid Levels and Composition in the Fetal Testis. Whiley PAF, et al. Endocrinology, 2020 Jul 1. PMID 32274496

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that IGFBP-rP10 is involved in the proliferation of osteoblasts during bone formation and bone regeneration.
    Title: Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells.
  2. Expression of Bono1 was detected in osteoblasts and secretory odontoblasts by in situ hybridization.
    Title: Bono1: a gene associated with regions of deposition of bone and dentine.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in interstitial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kazal-type serine protease inhibitor domain-containing protein 1
Names
IGFBP-related protein 10
Kazal-type serine protease inhibitor domain 1
bone and odontoblast-expressed protein 1
insulin-like growth factor-binding-related protein 10
insulin-like growth factor-binding-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362397.1 → NP_001349326.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC132957
    UniProtKB/TrEMBL
    Q3U2U8
    Conserved Domains (3) summary
    cd00104
    Location:136 → 175
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00219
    Location:61 → 115
    IGFBP; Insulin-like growth factor binding protein
    pfam07679
    Location:179 → 277
    I-set; Immunoglobulin I-set domain

  2. NM_001362398.1 → NP_001349327.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC132957
    Consensus CDS
    CCDS29857.1
    UniProtKB/Swiss-Prot
    Q14BR9, Q8BJ66
    UniProtKB/TrEMBL
    Q3U2U8
    Related
    ENSMUSP00000107579.2, ENSMUST00000111948.8
    Conserved Domains (4) summary
    cd00104
    Location:136 → 175
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00219
    Location:61 → 115
    IGFBP; Insulin-like growth factor binding protein
    pfam07679
    Location:179 → 277
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:187 → 190
    Ig; Ig strand A' [structural motif]

  3. NM_178929.5 → NP_849260.2  kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_849260.2

    Status: VALIDATED

    Source sequence(s)
    AI842353, AI847274, BB618180, BB869960, BB871162, BC115642
    Consensus CDS
    CCDS29857.1
    UniProtKB/Swiss-Prot
    Q14BR9, Q8BJ66
    UniProtKB/TrEMBL
    Q3U2U8
    Related
    ENSMUSP00000026234.5, ENSMUST00000026234.5
    Conserved Domains (4) summary
    cd00104
    Location:136 → 175
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00219
    Location:61 → 115
    IGFBP; Insulin-like growth factor binding protein
    pfam07679
    Location:179 → 277
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:187 → 190
    Ig; Ig strand A' [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45063404..45067728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526567.4 → XP_006526630.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006526630.1

    UniProtKB/Swiss-Prot
    Q14BR9, Q8BJ66
    UniProtKB/TrEMBL
    Q3U2U8
    Conserved Domains (4) summary
    cd00104
    Location:136 → 175
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00219
    Location:61 → 115
    IGFBP; Insulin-like growth factor binding protein
    pfam07679
    Location:179 → 277
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:187 → 190
    Ig; Ig strand A' [structural motif]

  2. XM_030250686.2 → XP_030106546.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q14BR9, Q8BJ66
    UniProtKB/TrEMBL
    Q3U2U8
    Conserved Domains (4) summary
    cd00104
    Location:136 → 175
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00219
    Location:61 → 115
    IGFBP; Insulin-like growth factor binding protein
    pfam07679
    Location:179 → 277
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:187 → 190
    Ig; Ig strand A' [structural motif]

  3. XM_006526566.3 → XP_006526629.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006526629.1

    UniProtKB/Swiss-Prot
    Q14BR9, Q8BJ66
    UniProtKB/TrEMBL
    Q3U2U8
    Conserved Domains (4) summary
    cd00104
    Location:136 → 175
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00219
    Location:61 → 115
    IGFBP; Insulin-like growth factor binding protein
    pfam07679
    Location:179 → 277
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:187 → 190
    Ig; Ig strand A' [structural motif]

  4. XM_017318042.2 → XP_017173531.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q14BR9, Q8BJ66
    UniProtKB/TrEMBL
    Q3U2U8
    Conserved Domains (4) summary
    cd00104
    Location:136 → 175
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00219
    Location:61 → 115
    IGFBP; Insulin-like growth factor binding protein
    pfam07679
    Location:179 → 277
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:187 → 190
    Ig; Ig strand A' [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ66.2 GenPept UniProtKB/Swiss-Prot:Q8BJ66

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