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Gpr137 G protein-coupled receptor 137 [ Mus musculus (house mouse) ]

Gene ID: 107173, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr137provided by MGI
Official Full Name
G protein-coupled receptor 137provided by MGI
Primary source
MGI:MGI:2147529
See related
Ensembl:ENSMUSG00000024958 AllianceGenome:MGI:2147529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Predicted to act upstream of or within autophagy. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Predicted to be active in lysosomal membrane. Is expressed in nervous system. Orthologous to human GPR137 (G protein-coupled receptor 137). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 48.3), adrenal adult (RPKM 46.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6915425..6919818, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6938057..6942450, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit zeta Neighboring gene potassium channel, subfamily K, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E4264 Neighboring gene STARR-positive B cell enhancer ABC_E9991 Neighboring gene STARR-positive B cell enhancer ABC_E8734 Neighboring gene BCL2-associated agonist of cell death Neighboring gene ATG2 autophagy related 2 homolog A pseudogene Neighboring gene phospholipase C, beta 3 Neighboring gene predicted gene, 52400

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR137 Inhibits Cell Proliferation and Promotes Neuronal Differentiation in the Neuro2a Cells. Iwasa K, et al. Neurochem Res, 2023 Mar. PMID 36436172, Free PMC Article
  2. An Alternative Splicing Program for Mouse Craniofacial Development. Hooper JE, et al. Front Physiol, 2020. PMID 33013468, Free PMC Article
  3. Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Lee S, et al. Development, 2020 Apr 30. PMID 32253237, Free PMC Article
  4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR137 Inhibits Cell Proliferation and Promotes Neuronal Differentiation in the Neuro2a Cells.
    Title: GPR137 Inhibits Cell Proliferation and Promotes Neuronal Differentiation in the Neuro2a Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integral membrane protein GPR137
Names
G protein-coupled receptor TM7SF1L1
transmembrane 7 superfamily member 1-like 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177360.2 → NP_001170831.1  integral membrane protein GPR137 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120557, AK142928, BC048078, CX200961
    Consensus CDS
    CCDS50371.1
    UniProtKB/TrEMBL
    E9Q9I0, Q3UQ21
    Related
    ENSMUSP00000097364.5, ENSMUST00000099776.6

  2. NM_001177361.2 → NP_001170832.1  integral membrane protein GPR137 isoform 3

    See identical proteins and their annotated locations for NP_001170832.1

    Status: VALIDATED

    Source sequence(s)
    AC120557, AK143450
    Consensus CDS
    CCDS50372.1
    UniProtKB/TrEMBL
    Q3UPL3
    Related
    ENSMUSP00000097370.4, ENSMUST00000099782.10

  3. NM_001177362.2 → NP_001170833.1  integral membrane protein GPR137 isoform 4

    See identical proteins and their annotated locations for NP_001170833.1

    Status: VALIDATED

    Source sequence(s)
    AC120557
    Consensus CDS
    CCDS50370.1
    UniProtKB/TrEMBL
    Q3TD99
    Related
    ENSMUSP00000097362.4, ENSMUST00000099774.10
    Conserved Domains (2) summary
    cd21464
    Location:38 → 60
    7tm_GPR137; TM helix 6 [structural motif]
    cl28897
    Location:30 → 143
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_001379534.1 → NP_001366463.1  integral membrane protein GPR137 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120557
    Conserved Domains (1) summary
    cd21474
    Location:16 → 352
    7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

  5. NM_001379535.1 → NP_001366464.1  integral membrane protein GPR137 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120557
    UniProtKB/TrEMBL
    Q3TD99
    Conserved Domains (2) summary
    cd21464
    Location:38 → 60
    7tm_GPR137; TM helix 6 [structural motif]
    cl28897
    Location:30 → 143
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. NM_001379536.1 → NP_001366465.1  integral membrane protein GPR137 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120557
    UniProtKB/TrEMBL
    Q3TD99
    Conserved Domains (2) summary
    cd21464
    Location:38 → 60
    7tm_GPR137; TM helix 6 [structural motif]
    cl28897
    Location:30 → 143
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. NM_207220.3 → NP_997103.1  integral membrane protein GPR137 isoform 1

    See identical proteins and their annotated locations for NP_997103.1

    Status: VALIDATED

    Source sequence(s)
    AC120557, BC048078, CX200961
    Consensus CDS
    CCDS29512.1
    UniProtKB/Swiss-Prot
    Q80UB6, Q80ZU9
    Related
    ENSMUSP00000130969.2, ENSMUST00000166115.9

RNA

  1. NR_166767.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120557
    Related
    ENSMUST00000235518.2

  2. NR_189038.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120557

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6915425..6919818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161372.1 → XP_036017265.1  integral membrane protein GPR137 isoform X2

  2. XM_006526557.5 → XP_006526620.1  integral membrane protein GPR137 isoform X1

    See identical proteins and their annotated locations for XP_006526620.1

RNA

  1. XR_001782554.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZU9.1 GenPept UniProtKB/Swiss-Prot:Q80ZU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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