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Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Mus musculus (house mouse) ]

Gene ID: 106952, updated on 21-Apr-2024

Summary

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Official Symbol
Arap3provided by MGI
Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by MGI
Primary source
MGI:MGI:2147274
See related
Ensembl:ENSMUSG00000024451 AllianceGenome:MGI:2147274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drag1; Centd3; cnt-d3; E030006K04Rik
Summary
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in lung adult (RPKM 62.4), subcutaneous fat pad adult (RPKM 16.7) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B3; 18 19.85 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38105676..38132583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37972623..37999531, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene histone deacetylase 3 Neighboring gene FCH and double SH3 domains 1 Neighboring gene RELT-like 2 Neighboring gene microRNA 6981 Neighboring gene microRNA 6980 Neighboring gene predicted gene, 30093 Neighboring gene predicted gene, 41701 Neighboring gene STARR-seq mESC enhancer starr_44342 Neighboring gene predicted gene, 30188 Neighboring gene STARR-seq mESC enhancer starr_44344 Neighboring gene predicted gene, 30142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of specific gene modules in mouse lung tissue exposed to cigarette smoke. Xing YH, et al. Asian Pac J Cancer Prev, 2015. PMID 26028081
  2. ARAP3 functions in hematopoietic stem cells. Song Y, et al. PLoS One, 2014. PMID 25542002, Free PMC Article
  3. A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites. McCormick B, et al. J Immunol, 2019 Sep 15. PMID 31427445, Free PMC Article
  4. The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. Gambardella L, et al. Blood, 2011 Jul 28. PMID 21490342
  5. Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3. Gambardella L, et al. J Immunol, 2013 Jan 1. PMID 23180820, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of Arap3 in osteoblasts and mesenchymal stromal cells using Prx1-Cre resulted in no discernable phenotypes in hematopoietic development or hematopoietic stem cells homeostasis in adult mice.
    Title: ARAP3 functions in hematopoietic stem cells.
  2. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development.
    Title: Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development.
  3. We report here the first characterization of the role of ARAP3 in murine neutrophils
    Title: The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.
  4. PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.
    Title: PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.
  5. the Nck adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor
    Title: Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
  6. ARAP3 has a role in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading
    Title: ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4097

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Names
ARF-GAP, RHO-GAP, ankyrin repeat and pleckstrin homology domains-containing protein 3
centaurin, delta 3
dual-specificity Rho- and Arf-GTPase activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205336.2 → NP_001192265.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC121886, AC129315
    Consensus CDS
    CCDS89225.1
    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Related
    ENSMUSP00000157868.2, ENSMUST00000237272.2
    Conserved Domains (8) summary
    cd04385
    Location:827 → 1002
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:206 → 298
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:313 → 396
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1131 → 1247
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    pfam00169
    Location:205 → 296
    PH; PH domain
    pfam00788
    Location:1035 → 1128
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:407 → 523
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:592 → 704
    PH-like; Pleckstrin homology-like domain

  2. NM_139206.3 → NP_631945.2  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_631945.2

    Status: REVIEWED

    Source sequence(s)
    AC121886, AC129315
    Consensus CDS
    CCDS29196.1
    UniProtKB/Swiss-Prot
    E9QMK7, Q5DTN4, Q6NVF1, Q8R5G6, Q8R5G7
    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Related
    ENSMUSP00000035662.8, ENSMUST00000042944.9
    Conserved Domains (10) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    PLN02983
    Location:1471 → 1537
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:81 → 311
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:905 → 1080
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:284 → 376
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:391 → 474
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1209 → 1325
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:484 → 599
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:670 → 782
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1112 → 1209
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    38105676..38132583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525492.4 → XP_006525555.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

    See identical proteins and their annotated locations for XP_006525555.1

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (9) summary
    PLN02983
    Location:1394 → 1460
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:3 → 234
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:828 → 1003
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:207 → 299
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:314 → 397
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1132 → 1248
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:407 → 522
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:593 → 705
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1035 → 1132
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_006525488.4 → XP_006525551.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006525551.1

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (10) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    PLN02983
    Location:1472 → 1538
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:81 → 312
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:906 → 1081
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1210 → 1326
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:671 → 783
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1113 → 1210
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_036160919.1 → XP_036016812.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (9) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:905 → 1080
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:284 → 376
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:391 → 474
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1209 → 1325
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:484 → 599
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    NF033838
    Location:81 → 150
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl17171
    Location:670 → 782
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1112 → 1209
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_006525489.3 → XP_006525552.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006525552.1

    UniProtKB/Swiss-Prot
    E9QMK7, Q5DTN4, Q6NVF1, Q8R5G6, Q8R5G7
    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (10) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    PLN02983
    Location:1471 → 1537
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:81 → 311
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:905 → 1080
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:284 → 376
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:391 → 474
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1209 → 1325
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:484 → 599
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:670 → 782
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1112 → 1209
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. XM_006525491.3 → XP_006525554.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

    See identical proteins and their annotated locations for XP_006525554.1

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (9) summary
    PLN02983
    Location:1394 → 1460
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:3 → 234
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:828 → 1003
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:207 → 299
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:314 → 397
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1132 → 1248
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:407 → 522
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:593 → 705
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1035 → 1132
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  6. XM_006525490.1 → XP_006525553.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (10) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    PLN02983
    Location:1459 → 1525
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:81 → 312
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:906 → 1081
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1210 → 1326
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:671 → 783
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1113 → 1210
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  7. XM_006525486.1 → XP_006525549.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006525549.1

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (10) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    PLN02983
    Location:1472 → 1538
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:81 → 312
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:906 → 1081
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1210 → 1326
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:671 → 783
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1113 → 1210
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  8. XM_036160921.1 → XP_036016814.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X6

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (9) summary
    PHA03247
    Location:3 → 233
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:827 → 1002
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:206 → 298
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:313 → 396
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1131 → 1247
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:406 → 521
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    NF033838
    Location:3 → 72
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl17171
    Location:592 → 704
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1034 → 1131
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  9. XM_030250262.2 → XP_030106122.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (9) summary
    PLN02983
    Location:1394 → 1460
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:3 → 234
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:828 → 1003
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:207 → 299
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:314 → 397
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1132 → 1248
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:407 → 522
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:593 → 705
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1035 → 1132
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  10. XM_006525487.5 → XP_006525550.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006525550.1

    UniProtKB/TrEMBL
    A0A2X0TVQ3
    Conserved Domains (10) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    PLN02983
    Location:1472 → 1538
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    PHA03247
    Location:81 → 312
    PHA03247; large tegument protein UL36; Provisional
    cd04385
    Location:906 → 1081
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:285 → 377
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:392 → 475
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13259
    Location:1210 → 1326
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17902
    Location:485 → 600
    ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
    cl17171
    Location:671 → 783
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:1113 → 1210
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RNA

  1. XR_003952486.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5G7.3 GenPept UniProtKB/Swiss-Prot:Q8R5G7

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