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Oard1 O-acyl-ADP-ribose deacylase 1 [ Mus musculus (house mouse) ]

Gene ID: 106821, updated on 5-Mar-2024

Summary

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Official Symbol
Oard1provided by MGI
Official Full Name
O-acyl-ADP-ribose deacylase 1provided by MGI
Primary source
MGI:MGI:2146818
See related
Ensembl:ENSMUSG00000040771 AllianceGenome:MGI:2146818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ADP-ribosylglutamate hydrolase activity; O-acetyl-ADP-ribose deacetylase activity; and purine nucleoside binding activity. Predicted to be involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to be located in nucleolus; nucleoplasm; and site of DNA damage. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 14.3), CNS E11.5 (RPKM 13.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 23.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48717028..48724298)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48409957..48417270)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene nuclear transcription factor-Y alpha Neighboring gene STARR-positive B cell enhancer ABC_E10961 Neighboring gene STARR-positive B cell enhancer ABC_E2492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48549466-48549575 Neighboring gene STARR-positive B cell enhancer ABC_E7541 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene STARR-seq mESC enhancer starr_42751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48567545-48567654 Neighboring gene predicted gene, 30283 Neighboring gene VISTA enhancer mm243 Neighboring gene translocator protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2. Ito H, et al. Dev Neurosci, 2018. PMID 30227424
  2. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP-ribosylglutamate hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables O-acetyl-ADP-ribose deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables purine nucleoside binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-glutamate ADP-deribosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-glutamate ADP-deribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein de-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleoside metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribose glycohydrolase OARD1
Names
O-acetyl-ADP-ribose deacetylase 1
[Protein ADP-ribosylglutamate] hydrolase OARD1
terminal ADP-ribose protein glycohydrolase 1
NP_001276419.1
NP_001276420.1
NP_001344832.1
NP_001344833.1
NP_001400515.1
NP_001400516.1
NP_001400517.1
NP_001400518.1
NP_001400520.1
NP_001400521.1
NP_001400522.1
NP_001400523.1
NP_001400524.1
NP_997102.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289490.1 → NP_001276419.1  ADP-ribose glycohydrolase OARD1 isoform 1

    See identical proteins and their annotated locations for NP_001276419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC166164, AK153512, AW558560, BC157987, BY741306
    Consensus CDS
    CCDS37647.1
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3
    Related
    ENSMUSP00000130802.2, ENSMUST00000167180.8
    Conserved Domains (1) summary
    cd02901
    Location:13 → 143
    Macro_Poa1p-like; macrodomain, Poa1p-like family

  2. NM_001289491.1 → NP_001276420.1  ADP-ribose glycohydrolase OARD1 isoform 1

    See identical proteins and their annotated locations for NP_001276420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC166164, AK153512, AW558560
    Consensus CDS
    CCDS37647.1
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3
    Conserved Domains (1) summary
    cd02901
    Location:13 → 143
    Macro_Poa1p-like; macrodomain, Poa1p-like family

  3. NM_001357903.1 → NP_001344832.1  ADP-ribose glycohydrolase OARD1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS37647.1
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3
    Conserved Domains (1) summary
    cd02901
    Location:13 → 143
    Macro_Poa1p-like; macrodomain, Poa1p-like family

  4. NM_001357904.1 → NP_001344833.1  ADP-ribose glycohydrolase OARD1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC166164, AW558560, BQ553673
    Consensus CDS
    CCDS37647.1
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3
    Conserved Domains (1) summary
    cd02901
    Location:13 → 143
    Macro_Poa1p-like; macrodomain, Poa1p-like family

  5. NM_001413586.1 → NP_001400515.1  ADP-ribose glycohydrolase OARD1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3

  6. NM_001413587.1 → NP_001400516.1  ADP-ribose glycohydrolase OARD1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3

  7. NM_001413588.1 → NP_001400517.1  ADP-ribose glycohydrolase OARD1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3

  8. NM_001413589.1 → NP_001400518.1  ADP-ribose glycohydrolase OARD1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3

  9. NM_001413591.1 → NP_001400520.1  ADP-ribose glycohydrolase OARD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166164

  10. NM_001413592.1 → NP_001400521.1  ADP-ribose glycohydrolase OARD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166164

  11. NM_001413593.1 → NP_001400522.1  ADP-ribose glycohydrolase OARD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166164

  12. NM_001413594.1 → NP_001400523.1  ADP-ribose glycohydrolase OARD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166164

  13. NM_001413595.1 → NP_001400524.1  ADP-ribose glycohydrolase OARD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166164

  14. NM_207219.4 → NP_997102.2  ADP-ribose glycohydrolase OARD1 isoform 1

    See identical proteins and their annotated locations for NP_997102.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC166164, AK153512, AW558560
    Consensus CDS
    CCDS37647.1
    UniProtKB/Swiss-Prot
    Q3U5M3, Q8R5F3
    Related
    ENSMUSP00000039280.7, ENSMUST00000046651.7
    Conserved Domains (1) summary
    cd02901
    Location:13 → 143
    Macro_Poa1p-like; macrodomain, Poa1p-like family

RNA

  1. NR_182169.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166164

  2. NR_182170.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166164

  3. NR_182171.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166164

  4. NR_182172.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166164

  5. NR_182173.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166164

  6. NR_182174.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166164

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48717028..48724298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939457.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5F3.2 GenPept UniProtKB/Swiss-Prot:Q8R5F3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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