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Tcf19 transcription factor 19 [ Mus musculus (house mouse) ]

Gene ID: 106795, updated on 5-Mar-2024

Summary

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Official Symbol
Tcf19provided by MGI
Official Full Name
transcription factor 19provided by MGI
Primary source
MGI:MGI:103180
See related
Ensembl:ENSMUSG00000050410 AllianceGenome:MGI:103180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730403J10Rik
Summary
Acts upstream of or within G1/S transition of mitotic cell cycle; regulation of gene expression; and type B pancreatic cell proliferation. Located in nucleus. Is expressed in forebrain; genitourinary system; and limb. Orthologous to human TCF19 (transcription factor 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 21.9), thymus adult (RPKM 20.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.69 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35823627..35827730, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35512730..35516837, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene Pou5f1 5' regulatory region Neighboring gene predicted gene, 32362 Neighboring gene POU domain, class 5, transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_42459 Neighboring gene STARR-positive B cell enhancer mm9_chr17:35653747-35654048 Neighboring gene coiled-coil alpha-helical rod protein 1 Neighboring gene psoriasis susceptibility 1 candidate 2 (human)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. Kanki JP, et al. J Neurobiol, 1994 Jul. PMID 8089660
  2. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. Ku DH, et al. Cell Growth Differ, 1991 Apr. PMID 1868030
  3. Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line. Krautkramer KA, et al. Am J Physiol Endocrinol Metab, 2013 Sep 1. PMID 23860123, Free PMC Article
  4. Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding. Bowen MA, et al. Eur J Immunol, 1997 Jun. PMID 9209500
  5. Individual retinal progenitor cells display extensive heterogeneity of gene expression. Trimarchi JM, et al. PLoS One, 2008 Feb 13. PMID 18270576, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor 19-like protein
Names
SC1 protein homolog
TCF-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163763.1 → NP_001157235.1  transcription factor 19-like protein

    See identical proteins and their annotated locations for NP_001157235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK004231, AK077414, AK078697, BB873636, BG082313
    Consensus CDS
    CCDS50089.1
    UniProtKB/Swiss-Prot
    Q8BPA3, Q99KJ5, Q9CT93
    UniProtKB/TrEMBL
    G3XA31
    Related
    ENSMUSP00000125167.2, ENSMUST00000160885.2
    Conserved Domains (2) summary
    cd00060
    Location:5 → 123
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR03354
    Location:36 → 240
    VI_FHA; type VI secretion system FHA domain protein

  2. NM_001163764.1 → NP_001157236.1  transcription factor 19-like protein

    See identical proteins and their annotated locations for NP_001157236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK004231, AK077414, BB873636, BG082313, CX220762
    Consensus CDS
    CCDS50089.1
    UniProtKB/Swiss-Prot
    Q8BPA3, Q99KJ5, Q9CT93
    UniProtKB/TrEMBL
    G3XA31
    Conserved Domains (2) summary
    cd00060
    Location:5 → 123
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR03354
    Location:36 → 240
    VI_FHA; type VI secretion system FHA domain protein

  3. NM_025674.2 → NP_079950.2  transcription factor 19-like protein

    See identical proteins and their annotated locations for NP_079950.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK004231, AK077414, BB873636, BG082313
    Consensus CDS
    CCDS50089.1
    UniProtKB/Swiss-Prot
    Q8BPA3, Q99KJ5, Q9CT93
    UniProtKB/TrEMBL
    G3XA31
    Related
    ENSMUSP00000125310.2, ENSMUST00000161012.8
    Conserved Domains (2) summary
    cd00060
    Location:5 → 123
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR03354
    Location:36 → 240
    VI_FHA; type VI secretion system FHA domain protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35823627..35827730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249438.2 → XP_030105298.1  transcription factor 19-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q8BPA3, Q99KJ5, Q9CT93
    UniProtKB/TrEMBL
    G3XA31
    Conserved Domains (2) summary
    cd00060
    Location:5 → 123
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR03354
    Location:36 → 240
    VI_FHA; type VI secretion system FHA domain protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KJ5.1 GenPept UniProtKB/Swiss-Prot:Q99KJ5

Gene LinkOut

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