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Stap2 signal transducing adaptor family member 2 [ Mus musculus (house mouse) ]

Gene ID: 106766, updated on 31-Mar-2024

Summary

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Official Symbol
Stap2provided by MGI
Official Full Name
signal transducing adaptor family member 2provided by MGI
Primary source
MGI:MGI:2147039
See related
Ensembl:ENSMUSG00000038781 AllianceGenome:MGI:2147039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STAP-2
Summary
Predicted to enable signaling adaptor activity. Located in plasma membrane. Orthologous to human STAP2 (signal transducing adaptor family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 46.6), duodenum adult (RPKM 34.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.1 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56304074..56315558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55997074..56008402, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene fibronectin type 3 and SPRY domain-containing protein Neighboring gene STARR-positive B cell enhancer ABC_E2497 Neighboring gene MPN domain containing Neighboring gene bolA-like 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:56160654-56160880 Neighboring gene SH3-domain GRB2-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals. Saitoh K, et al. J Immunol, 2022 Jul 1. PMID 35725273
  2. Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice. Saito H, et al. Biochem Biophys Res Commun, 2021 Jan 22. PMID 33388414
  3. Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress. Ichii M, et al. Haematologica, 2021 Feb 1. PMID 31974192, Free PMC Article
  4. STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions. Kashiwakura JI, et al. Int Immunol, 2019 Apr 26. PMID 30726917
  5. Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis. Fujita N, et al. Eur J Immunol, 2014 Jun. PMID 24733425

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
    Title: STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
  2. STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
    Title: STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
  3. STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals.
    Title: STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals.
  4. Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation.
    Title: Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation.
  5. Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress.
    Title: Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress.
  6. Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.
    Title: Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.
  7. The STAP-2 is an adaptor molecule that positively regulates FcepsilonRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions.
    Title: STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions.
  8. These findings indicate an essential role for STAP2 in the generation of a high-quality memory CD8+ CTLs periphery, and suggest the therapeutic potential of STAP2 in cancer patients.
    Title: Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.
  9. results demonstrate a contribution of CCR7 to STAP-2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells
    Title: CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells.
  10. signal transducing adaptor protein 2 (STAP-2) is involved in cell migration, proliferation, and melanogenesis as well as chemokine receptor expression and tumorigenesis in B16F10 melanoma cells
    Title: STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
signal-transducing adaptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410325.1 → NP_001397254.1  signal-transducing adaptor protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009719
    UniProtKB/Swiss-Prot
    Q8BWS2, Q8R0L1
    Related
    ENSMUSP00000038130.7, ENSMUST00000043785.8

  2. NM_145934.3 → NP_666046.1  signal-transducing adaptor protein 2 isoform 1

    See identical proteins and their annotated locations for NP_666046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AK050131, AW049765, CT009719
    Consensus CDS
    CCDS28889.1
    UniProtKB/Swiss-Prot
    Q8BWS2, Q8R0L1
    Conserved Domains (2) summary
    cd10404
    Location:151 → 247
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cl17171
    Location:9 → 135
    PH-like; Pleckstrin homology-like domain

RNA

  1. NR_102313.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK050172, CT009719
    Related
    ENSMUST00000233494.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56304074..56315558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160253.1 → XP_036016146.1  signal-transducing adaptor protein 2 isoform X2

    Conserved Domains (2) summary
    cd10404
    Location:151 → 247
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cl17171
    Location:9 → 135
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0L1.1 GenPept UniProtKB/Swiss-Prot:Q8R0L1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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