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Catsperd cation channel sperm associated auxiliary subunit delta [ Mus musculus (house mouse) ]

Gene ID: 106757, updated on 12-May-2024

Summary

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Official Symbol
Catsperdprovided by MGI
Official Full Name
cation channel sperm associated auxiliary subunit deltaprovided by MGI
Primary source
MGI:MGI:2147030
See related
Ensembl:ENSMUSG00000040828 AllianceGenome:MGI:2147030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
619718; Gm6095; Tmem146; 4921529N20Rik; 4933402B14Rik
Summary
Involved in flagellated sperm motility and sperm capacitation. Located in sperm principal piece. Part of CatSper complex. Orthologous to human CATSPERD (cation channel sperm associated auxiliary subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 33.0), stomach adult (RPKM 5.5) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.43 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56933917..56971456)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56626911..56664456)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3210 Neighboring gene predicted gene, 33461 Neighboring gene STARR-seq mESC enhancer starr_42897 Neighboring gene RAN binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_42898 Neighboring gene STARR-positive B cell enhancer ABC_E962 Neighboring gene calcyphosine, pseudogene Neighboring gene vimentin-type intermediate filament associated coiled-coil protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Chung JJ, et al. Cell, 2014 May 8. PMID 24813608, Free PMC Article
  2. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Hwang JY, et al. Cell Rep, 2022 Jan 18. PMID 34998468, Free PMC Article
  3. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Hwang JY, et al. Cell, 2019 May 30. PMID 31056283, Free PMC Article
  4. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Chung JJ, et al. Elife, 2017 Feb 23. PMID 28226241, Free PMC Article
  5. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm capacitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cation channel sperm-associated auxiliary subunit delta
Names
catSper-delta
catSperdelta
cation channel sperm-associated protein subunit delta
transmembrane protein 146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357897.1 → NP_001344826.1  cation channel sperm-associated auxiliary subunit delta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AW045609, CT010491, CT485788
    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 467
    CATSPERD; Cation channel sperm-associated protein subunit delta

  2. NM_175350.3 → NP_780559.2  cation channel sperm-associated auxiliary subunit delta isoform 1 precursor

    See identical proteins and their annotated locations for NP_780559.2

    Status: VALIDATED

    Source sequence(s)
    CT010491, CT485788
    Consensus CDS
    CCDS50153.1
    UniProtKB/Swiss-Prot
    E7DZL7, E7DZL8, E9Q710, E9Q9F6, Q1JPR3, Q1LZJ6, Q8C5U5
    Related
    ENSMUSP00000108603.3, ENSMUST00000112979.4
    Conserved Domains (1) summary
    pfam15020
    Location:38 → 766
    CATSPERD; Cation channel sperm-associated protein subunit delta

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56933917..56971456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523433.4 → XP_006523496.1  cation channel sperm-associated auxiliary subunit delta isoform X9

    See identical proteins and their annotated locations for XP_006523496.1

    Conserved Domains (1) summary
    pfam15020
    Location:1 → 592
    CATSPERD; Cation channel sperm-associated protein subunit delta

  2. XM_006523436.4 → XP_006523499.1  cation channel sperm-associated auxiliary subunit delta isoform X11

    See identical proteins and their annotated locations for XP_006523499.1

    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 571
    CATSPERD; Cation channel sperm-associated protein subunit delta

  3. XM_006523430.5 → XP_006523493.1  cation channel sperm-associated auxiliary subunit delta isoform X7

    Conserved Domains (1) summary
    pfam15020
    Location:32 → 768
    CATSPERD; Cation channel sperm-associated protein subunit delta

  4. XM_030249429.2 → XP_030105289.1  cation channel sperm-associated auxiliary subunit delta isoform X12

    Conserved Domains (1) summary
    pfam15020
    Location:84 → 596
    CATSPERD; Cation channel sperm-associated protein subunit delta

  5. XM_006523424.4 → XP_006523487.2  cation channel sperm-associated auxiliary subunit delta isoform X1

    Conserved Domains (1) summary
    pfam15020
    Location:65 → 763
    CATSPERD; Cation channel sperm-associated protein subunit delta

  6. XM_006523428.3 → XP_006523491.1  cation channel sperm-associated auxiliary subunit delta isoform X5

    Conserved Domains (1) summary
    pfam15020
    Location:38 → 774
    CATSPERD; Cation channel sperm-associated protein subunit delta

  7. XM_006523434.4 → XP_006523497.1  cation channel sperm-associated auxiliary subunit delta isoform X9

    See identical proteins and their annotated locations for XP_006523497.1

    Conserved Domains (1) summary
    pfam15020
    Location:1 → 592
    CATSPERD; Cation channel sperm-associated protein subunit delta

  8. XM_006523437.4 → XP_006523500.1  cation channel sperm-associated auxiliary subunit delta isoform X11

    See identical proteins and their annotated locations for XP_006523500.1

    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 571
    CATSPERD; Cation channel sperm-associated protein subunit delta

  9. XM_030249428.1 → XP_030105288.1  cation channel sperm-associated auxiliary subunit delta isoform X10

    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 584
    CATSPERD; Cation channel sperm-associated protein subunit delta

  10. XM_030249431.1 → XP_030105291.1  cation channel sperm-associated auxiliary subunit delta isoform X14

    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:9 → 454
    CATSPERD; Cation channel sperm-associated protein subunit delta

  11. XM_030249424.1 → XP_030105284.1  cation channel sperm-associated auxiliary subunit delta isoform X3

    Conserved Domains (1) summary
    pfam15020
    Location:1 → 549
    CATSPERD; Cation channel sperm-associated protein subunit delta

  12. XM_030249425.1 → XP_030105285.1  cation channel sperm-associated auxiliary subunit delta isoform X4

    Conserved Domains (1) summary
    pfam15020
    Location:1 → 548
    CATSPERD; Cation channel sperm-associated protein subunit delta

  13. XM_030249423.1 → XP_030105283.1  cation channel sperm-associated auxiliary subunit delta isoform X2

    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 554
    CATSPERD; Cation channel sperm-associated protein subunit delta

  14. XM_030249427.1 → XP_030105287.1  cation channel sperm-associated auxiliary subunit delta isoform X8

    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 467
    CATSPERD; Cation channel sperm-associated protein subunit delta

  15. XM_030249426.1 → XP_030105286.1  cation channel sperm-associated auxiliary subunit delta isoform X6

    UniProtKB/TrEMBL
    A0A3B2WD76
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 546
    CATSPERD; Cation channel sperm-associated protein subunit delta

  16. XM_030249430.1 → XP_030105290.1  cation channel sperm-associated auxiliary subunit delta isoform X9

    Conserved Domains (1) summary
    pfam15020
    Location:1 → 592
    CATSPERD; Cation channel sperm-associated protein subunit delta

  17. XM_011246244.2 → XP_011244546.1  cation channel sperm-associated auxiliary subunit delta isoform X13

    UniProtKB/TrEMBL
    A0A3B2WD76
    Related
    ENSMUSP00000156886.2, ENSMUST00000233947.2
    Conserved Domains (1) summary
    pfam15020
    Location:1 → 455
    CATSPERD; Cation channel sperm-associated protein subunit delta
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q9F6.1 GenPept UniProtKB/Swiss-Prot:E9Q9F6

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