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Cyp4f15 cytochrome P450, family 4, subfamily f, polypeptide 15 [ Mus musculus (house mouse) ]

Gene ID: 106648, updated on 8-Feb-2024

Summary

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Official Symbol
Cyp4f15provided by MGI
Official Full Name
cytochrome P450, family 4, subfamily f, polypeptide 15provided by MGI
Primary source
MGI:MGI:2146921
See related
Ensembl:ENSMUSG00000073424 AllianceGenome:MGI:2146921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp4f-15
Summary
Predicted to enable fatty acid binding activity; heme binding activity; and monooxygenase activity. Predicted to be involved in icosanoid catabolic process; omega-hydroxylase P450 pathway; and quinone catabolic process. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 70.8), bladder adult (RPKM 60.4) and 4 other tissues See more
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Genomic context

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Location:
17 B1; 17 17.76 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32904605..32922329)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32685631..32703352)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily f, member 38, pseudogene Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 40 Neighboring gene predicted gene, 53996 Neighboring gene non-SMC element 1 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alkane 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-tocopherol omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonic acid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-B4 20-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene-B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
Inferred from Sequence Orthology
more info
  
enables tocotrienol omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene B4 catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene B4 catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in omega-hydroxylase P450 pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450, family 4, subfamily f, polypeptide 15
Names
cytochrome P450 CYP4F15
cytochrome P450, 4f15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346538.1 → NP_001333467.1  cytochrome P450, family 4, subfamily f, polypeptide 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT033759, CT485613
    Consensus CDS
    CCDS84293.1
    UniProtKB/TrEMBL
    Q8VCA4
    Related
    ENSMUSP00000008801.7, ENSMUST00000008801.7

  2. NM_134127.1 → NP_598888.1  cytochrome P450, family 4, subfamily f, polypeptide 15 isoform 1

    See identical proteins and their annotated locations for NP_598888.1

    Status: VALIDATED

    Source sequence(s)
    AF233645
    Consensus CDS
    CCDS28620.1
    UniProtKB/TrEMBL
    Q99N18
    Related
    ENSMUSP00000129264.2, ENSMUST00000168171.8
    Conserved Domains (1) summary
    pfam00067
    Location:57 → 526
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32904605..32922329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523412.3 → XP_006523475.1  cytochrome P450, family 4, subfamily f, polypeptide 15 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:2 → 300
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version

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