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CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 [ Homo sapiens (human) ]

Gene ID: 10645, updated on 3-Apr-2024

Summary

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Official Symbol
CAMKK2provided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase kinase 2provided by HGNC
Primary source
HGNC:HGNC:1470
See related
Ensembl:ENSG00000110931 MIM:615002; AllianceGenome:HGNC:1470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKK; CAMKKB
Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in brain (RPKM 24.4), spleen (RPKM 11.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q24.31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121237692..121297819, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121228458..121289212, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121675495..121735622, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7157 Neighboring gene NANOG hESC enhancer GRCh37_chr12:121593595-121594096 Neighboring gene purinergic receptor P2X 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121627731-121628231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121661200-121661700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7159 Neighboring gene Sharpr-MPRA regulatory region 10951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121671545-121672172 Neighboring gene purinergic receptor P2X 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4971 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121683587-121683800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121693396-121693896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720271-121720878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720879-121721486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4972 Neighboring gene anaphase promoting complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121773208-121773399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121789289-121789964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121790641-121791316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121791317-121791990 Neighboring gene uncharacterized LOC124903037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7163

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of CaMKK2 in Golgi-associated vesicle trafficking. Kennedy G, et al. Biochem Soc Trans, 2023 Feb 27. PMID 36815702, Free PMC Article
  2. Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma. Tomaszewski WH, et al. Nat Commun, 2022 Oct 29. PMID 36309495, Free PMC Article
  3. Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ. Wu F, et al. Cell Mol Life Sci, 2022 Apr 19. PMID 35438341, Free PMC Article
  4. Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid. Merhi F, et al. Cells, 2021 Nov 30. PMID 34943872, Free PMC Article
  5. Brief Report: Polymorphisms in CAMKK2 may Influence Domain-Specific Neurocognitive Function in HIV+ Indonesians Receiving ART. Gaff J, et al. J Acquir Immune Defic Syndr, 2022 Jan 1. PMID 34878439

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant.
    Title: Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant.
  2. CaMKK2 as an emerging treatment target for bipolar disorder.
    Title: CaMKK2 as an emerging treatment target for bipolar disorder.
  3. Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis.
    Title: Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis.
  4. Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.
    Title: Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.
  5. The role of CaMKK2 in Golgi-associated vesicle trafficking.
    Title: The role of CaMKK2 in Golgi-associated vesicle trafficking.
  6. Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.
    Title: Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.
  7. Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKbeta.
    Title: Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ.
  8. Brief Report: Polymorphisms in CAMKK2 may Influence Domain-Specific Neurocognitive Function in HIV+ Indonesians Receiving ART.
    Title: Brief Report: Polymorphisms in CAMKK2 may Influence Domain-Specific Neurocognitive Function in HIV+ Indonesians Receiving ART.
  9. CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner.
    Title: CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner.
  10. CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation.
    Title: CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation.
Submit: New GeneRIF Correction See all GeneRIFs (78)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of calcium/calmodulin-dependent protein kinase kinase 2 beta (CAMKK2) by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0787, MGC15254

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in CAMKK-AMPK signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CAMKK-AMPK signaling cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in MAPK cascade TAS
Traceable Author Statement
more info
 PubMed 
involved_in calcium-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to reactive oxygen species TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of autophagy of mitochondrion IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase kinase 2
Names
CAMKK beta protein
caM-KK 2
caM-KK beta
caM-kinase kinase 2
caM-kinase kinase beta
calcium/calmodulin-dependent protein kinase beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
NP_001257414.1
NP_001257415.1
NP_006540.3
NP_705719.2
NP_705720.1
NP_757363.1
NP_757364.1
NP_757365.1
NP_757380.1
XP_005253879.1
XP_005253880.1
XP_005253881.1
XP_011536065.1
XP_011536066.1
XP_016874191.1
XP_047284057.1
XP_047284058.1
XP_047284059.1
XP_047284060.1
XP_047284061.1
XP_047284062.1
XP_047284063.1
XP_047284064.1
XP_047284065.1
XP_054226771.1
XP_054226772.1
XP_054226773.1
XP_054226774.1
XP_054226775.1
XP_054226776.1
XP_054226777.1
XP_054226778.1
XP_054226779.1
XP_054226780.1
XP_054226781.1
XP_054226782.1
XP_054226783.1
XP_054226784.1
XP_054226785.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029409.1 RefSeqGene

    Range
    6600..65617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270485.2 → NP_001257414.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_001257414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1, and encodes isoform (1). Variants 1 and 8 encode the same protein (isoform 1).
    Source sequence(s)
    AA678930, AB081336, AF287630, AL834322, BC026060, DA075361
    Consensus CDS
    CCDS9216.1
    UniProtKB/Swiss-Prot
    A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000384600.3, ENST00000404169.8
    Conserved Domains (1) summary
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  2. NM_001270486.1 → NP_001257415.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 7

    See identical proteins and their annotated locations for NP_001257415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks a segment in the 3' coding region and 3' UTR, which leads to a frameshift, compared to variant 1. The resulting isoform (7) contains a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA678930, AB018330, AF321385, AL834322
    Consensus CDS
    CCDS58283.1
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000376266.2, ENST00000392474.6
    Conserved Domains (2) summary
    smart00220
    Location:165 → 446
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  3. NM_006549.4 → NP_006540.3  calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_006540.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as beta 1, represents the longest transcript, and encodes the longest isoform (1). Variants 1 and 8 encode the same protein (isoform 1).
    Source sequence(s)
    AC069209
    Consensus CDS
    CCDS9216.1
    UniProtKB/Swiss-Prot
    A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000312741.5, ENST00000324774.9
    Conserved Domains (1) summary
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  4. NM_153499.3 → NP_705719.2  calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_705719.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as beta 1del16, lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1. This isoform (2) is also encoded by variant 7.
    Source sequence(s)
    AC069209
    Consensus CDS
    CCDS9218.1
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000336634.3, ENST00000337174.7
    Conserved Domains (1) summary
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  5. NM_153500.2 → NP_705720.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 4

    See identical proteins and their annotated locations for NP_705720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta 1del14del16, has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC069209
    Consensus CDS
    CCDS9219.1
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000445944.1, ENST00000538733.5
    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  6. NM_172214.3 → NP_757363.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 5

    See identical proteins and their annotated locations for NP_757363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as beta 2, contains an alternate segment in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC069209, AF287631
    Consensus CDS
    CCDS44999.1
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000376265.2, ENST00000392473.2
    Conserved Domains (1) summary
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  7. NM_172215.3 → NP_757364.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 6

    See identical proteins and their annotated locations for NP_757364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as beta 2del14, differs in the 3' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (6) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC069209, AF287631
    Consensus CDS
    CCDS53837.1
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000388273.2, ENST00000446440.6
    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  8. NM_172216.2 → NP_757365.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 3

    See identical proteins and their annotated locations for NP_757365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as beta 1del14, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC069209
    Consensus CDS
    CCDS9217.1
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000321230.3, ENST00000347034.6
    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  9. NM_172226.3 → NP_757380.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_757380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and also lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1. This isoform (2) is also encoded by variant 2.
    Source sequence(s)
    AB018330, AC069209, AI612762, BC026060, DA075361
    Consensus CDS
    CCDS9218.1
    UniProtKB/TrEMBL
    B4DV02
    Related
    ENSP00000388368.2, ENST00000412367.6
    Conserved Domains (1) summary
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    121237692..121297819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018702.3 → XP_016874191.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

    UniProtKB/TrEMBL
    B4DV02
    Conserved Domains (2) summary
    smart00220
    Location:165 → 446
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  2. XM_005253824.3 → XP_005253881.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

    See identical proteins and their annotated locations for XP_005253881.1

    UniProtKB/TrEMBL
    B4DV02
    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  3. XM_047428105.1 → XP_047284061.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6

  4. XM_005253822.3 → XP_005253879.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3

    See identical proteins and their annotated locations for XP_005253879.1

    UniProtKB/TrEMBL
    B4DV02
    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  5. XM_011537763.1 → XP_011536065.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_011536065.1

    UniProtKB/TrEMBL
    B4DV02
    Conserved Domains (2) summary
    smart00220
    Location:165 → 446
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  6. XM_047428107.1 → XP_047284063.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

  7. XM_047428103.1 → XP_047284059.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4

  8. XM_047428102.1 → XP_047284058.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

  9. XM_047428101.1 → XP_047284057.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2

  10. XM_011537764.3 → XP_011536066.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10

    Conserved Domains (2) summary
    smart00220
    Location:9 → 282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:9 → 283
    PKc_like; Protein Kinases, catalytic domain

  11. XM_047428109.1 → XP_047284065.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X11

  12. XM_047428108.1 → XP_047284064.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9

  13. XM_005253823.1 → XP_005253880.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

    See identical proteins and their annotated locations for XP_005253880.1

    UniProtKB/TrEMBL
    B4DV02
    Conserved Domains (1) summary
    cd14199
    Location:162 → 447
    STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2

  14. XM_047428104.1 → XP_047284060.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

  15. XM_047428106.1 → XP_047284062.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    121228458..121289212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370799.1 → XP_054226774.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

  2. XM_054370806.1 → XP_054226781.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

  3. XM_054370804.1 → XP_054226779.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6

  4. XM_054370800.1 → XP_054226775.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3

  5. XM_054370797.1 → XP_054226772.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

  6. XM_054370807.1 → XP_054226782.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

  7. XM_054370801.1 → XP_054226776.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4

  8. XM_054370798.1 → XP_054226773.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

  9. XM_054370796.1 → XP_054226771.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2

  10. XM_054370809.1 → XP_054226784.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10

  11. XM_054370810.1 → XP_054226785.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X11

  12. XM_054370808.1 → XP_054226783.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9

  13. XM_054370802.1 → XP_054226777.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

  14. XM_054370803.1 → XP_054226778.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

  15. XM_054370805.1 → XP_054226780.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RR4.2 GenPept UniProtKB/Swiss-Prot:Q96RR4

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