Slc51a solute carrier family 51, alpha subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc51aprovided by MGI
Official Full Name: solute carrier family 51, alpha subunitprovided by MGI
Primary source: MGI:MGI:2146634
See related: Ensembl:ENSMUSG00000035699 AllianceGenome:MGI:2146634
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Osta; OSTalpha; D630035O19Rik
Summary: Enables bile acid transmembrane transporter activity; protein heterodimerization activity; and protein homodimerization activity. Involved in bile acid and bile salt transport. Acts upstream of or within organic substance transport. Located in basolateral plasma membrane and endoplasmic reticulum membrane. Is integral component of membrane. Part of protein-containing complex. Is expressed in midgut and small intestine. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SLC51A (solute carrier family 51 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 385.9), duodenum adult (RPKM 99.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 22.7 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (32294396..32306697, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (32475578..32487879, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB are inactive.
Title: Global functions of extracellular, transmembrane and cytoplasmic domains of organic solute transporter β-subunit.
These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin resistance.
Title: Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.
Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE(-/-) mice deficient in Ostalpha.
Title: Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE⁻/⁻ mice.
Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression
Title: Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism.
Inactivation of FXR largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.
Title: Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice.
Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.
Title: Ostα depletion protects liver from oral bile acid load.
OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis
Title: Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.
Title: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.
These findings provide direct support for the hypothesis that Ostalpha-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver.
Title: Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver.
These data indicate that Ostalpha-Ostbeta is essential for intestinal bile acid transport in mice.
Title: The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

AW261577 (e-PCR)
- UniSTS:180891

NoName (e-PCR)
- UniSTS:237486

AV001382 (e-PCR)
- UniSTS:164602

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IPI Inferred from Physical Interaction more info	PubMed
enables transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid and bile salt transport	IPI Inferred from Physical Interaction more info	PubMed
involved_in bile acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organic substance transport	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: organic solute transporter subunit alpha

Names: OST-alpha; organic solute transporter alpha; solute carrier family 51 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.