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Ypel1 yippee like 1 [ Mus musculus (house mouse) ]

Gene ID: 106369, updated on 21-Apr-2024

Summary

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Official Symbol
Ypel1provided by MGI
Official Full Name
yippee like 1provided by MGI
Primary source
MGI:MGI:1913303
See related
Ensembl:ENSMUSG00000022773 AllianceGenome:MGI:1913303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dgl1; DGL-1; Ppil2; mdgl-1; 0610009L05Rik; 1700016N17Rik; 1700019O22Rik; 4921520K19Rik; 4930511F14Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be located in nucleus. Is expressed in several structures, including brain; endocrine gland; genitourinary system; hemolymphoid system gland; and white fat. Orthologous to human YPEL1 (yippee like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 54.8), CNS E18 (RPKM 18.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 10.58 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16887454..16904912)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17070139..17087048)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6438 Neighboring gene STARR-positive B cell enhancer ABC_E9426 Neighboring gene mitogen-activated protein kinase 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b Neighboring gene microRNA 301b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ypel1: a novel nuclear protein that induces an epithelial-like morphology in fibroblasts. Farlie P, et al. Genes Cells, 2001 Jul. PMID 11473580
  2. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Cotter L, et al. Science, 2010 Jun 11. PMID 20448149
  3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
  4. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Hosono K, et al. Genomics, 2010 Aug. PMID 20580816
  5. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein yippee-like 1
Names
cardiac Abnormality/abnormal facies (CATCH22), microdeletion syndrome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291047.1 → NP_001277976.1  protein yippee-like 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK006505, AK014931, AK139453, BB610926, BB649357
    UniProtKB/Swiss-Prot
    Q9ESC7
    UniProtKB/TrEMBL
    Q65Z96
    Conserved Domains (1) summary
    cl13152
    Location:96 → 185
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. NM_001291053.1 → NP_001277982.1  protein yippee-like 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK006505, AK014931, AK139453, BB649357, BQ573264
    UniProtKB/TrEMBL
    Q810N0
    Related
    ENSMUST00000231518.2
    Conserved Domains (1) summary
    cl13152
    Location:13 → 80
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  3. NM_023249.6 → NP_075738.1  protein yippee-like 1 isoform 2

    See identical proteins and their annotated locations for NP_075738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK006505, AK014931, AK139453, BB649357
    Consensus CDS
    CCDS37268.1
    UniProtKB/Swiss-Prot
    Q9ESC7
    UniProtKB/TrEMBL
    Q65Z96
    Related
    ENSMUSP00000039760.8, ENSMUST00000035682.16
    Conserved Domains (1) summary
    cl13152
    Location:20 → 108
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16887454..16904912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521679.4 → XP_006521742.1  protein yippee-like 1 isoform X4

    See identical proteins and their annotated locations for XP_006521742.1

    UniProtKB/TrEMBL
    A0A338P6Z8
    Related
    ENSMUSP00000156213.2, ENSMUST00000232574.2

  2. XM_006521681.5 → XP_006521744.1  protein yippee-like 1 isoform X6

  3. XM_006521677.2 → XP_006521740.1  protein yippee-like 1 isoform X3

    UniProtKB/TrEMBL
    Q9DA95

  4. XM_006521675.5 → XP_006521738.1  protein yippee-like 1 isoform X1

    UniProtKB/TrEMBL
    Q9DA95

  5. XM_006521676.5 → XP_006521739.1  protein yippee-like 1 isoform X2

    Conserved Domains (1) summary
    cl13152
    Location:107 → 197
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  6. XM_030248914.1 → XP_030104774.1  protein yippee-like 1 isoform X5

    UniProtKB/Swiss-Prot
    Q9ESC7
    UniProtKB/TrEMBL
    Q65Z96
    Conserved Domains (1) summary
    cl13152
    Location:20 → 108
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  7. XM_006521680.2 → XP_006521743.1  protein yippee-like 1 isoform X4

    See identical proteins and their annotated locations for XP_006521743.1

    UniProtKB/TrEMBL
    A0A338P6Z8
    Conserved Domains (1) summary
    cl13152
    Location:21 → 94
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESC7.1 GenPept UniProtKB/Swiss-Prot:Q9ESC7

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