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RASL10A RAS like family 10 member A [ Homo sapiens (human) ]

Gene ID: 10633, updated on 5-Mar-2024

Summary

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Official Symbol
RASL10Aprovided by HGNC
Official Full Name
RAS like family 10 member Aprovided by HGNC
Primary source
HGNC:HGNC:16954
See related
Ensembl:ENSG00000100276 MIM:602220; AllianceGenome:HGNC:16954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRP22
Summary
Predicted to enable GTPase activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in nucleolus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.1) and testis (RPKM 0.5) See more
Orthologs
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Genomic context

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Location:
22q12.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (29312933..29319859, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (29776344..29783270, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29708922..29711686, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29663849-29664720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18813 Neighboring gene EWS RNA binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29698939-29699439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29701647-29702392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29702393-29703136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29710073-29710877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29710878-29711682 Neighboring gene growth arrest specific 2 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29726349-29727305 Neighboring gene small nucleolar RNA, C/D box 125 Neighboring gene adaptor related protein complex 1 subunit beta 1 Neighboring gene ret finger protein like 1 Neighboring gene uncharacterized LOC102723305

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas. Schmidt N, et al. Brain Pathol, 2012 Jan. PMID 21631628, Free PMC Article
  2. RRP22: a novel neural tumor suppressor for astrocytoma. Chen R, et al. Med Oncol, 2012 Mar. PMID 21264544
  3. 22q11.2 deletion syndrome: are motor deficits more than expected for IQ level? Roizen NJ, et al. J Pediatr, 2010 Oct. PMID 20646714, Free PMC Article
  4. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. Elam C, et al. Cancer Res, 2005 Apr 15. PMID 15833841
  5. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. Zucman-Rossi J, et al. Genomics, 1996 Dec 15. PMID 8975699

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RRP22 is a special neural tumor suppressor for human astrocytomas
    Title: RRP22: a novel neural tumor suppressor for astrocytoma.
  2. Both 5'-CpG island hypermethylation and histone modifications contribute to the frequent and prognostically unfavorable transcriptional downregulation of RRP22 in malignant gliomas.
    Title: DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas.
  3. chromosome 22 have specific motor deficits in axial stability and graphomotor skills.
    Title: 22q11.2 deletion syndrome: are motor deficits more than expected for IQ level?
  4. RRP22 localizes to the nucleolus in a GTP-dependent manner and can serve as a potential tumor suppressor.
    Title: RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC002059.10

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in small GTPase-mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-like protein family member 10A
Names
ras-like protein RRP22
ras-related protein on chromosome 22
NP_006468.1
XP_011528124.1
XP_011528125.1
XP_054180956.1
XP_054180957.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006477.5 → NP_006468.1  ras-like protein family member 10A

    See identical proteins and their annotated locations for NP_006468.1

    Status: VALIDATED

    Source sequence(s)
    AC002059, BX111994, Y07847
    Consensus CDS
    CCDS13854.1
    UniProtKB/Swiss-Prot
    Q49AU5, Q6PI03, Q92737
    Related
    ENSP00000216101.6, ENST00000216101.7
    Conserved Domains (1) summary
    cl38936
    Location:5 → 203
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    29312933..29319859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529823.2 → XP_011528125.1  ras-like protein family member 10A isoform X2

    Conserved Domains (1) summary
    cl21455
    Location:25 → 155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_011529822.1 → XP_011528124.1  ras-like protein family member 10A isoform X1

    See identical proteins and their annotated locations for XP_011528124.1

    Conserved Domains (1) summary
    cl21455
    Location:86 → 223
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    29776344..29783270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324982.1 → XP_054180957.1  ras-like protein family member 10A isoform X2

  2. XM_054324981.1 → XP_054180956.1  ras-like protein family member 10A isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007279.1: Suppressed sequence

    Description
    NM_001007279.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92737.1 GenPept UniProtKB/Swiss-Prot:Q92737

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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