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Qtrt2 queuine tRNA-ribosyltransferase accessory subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 106248, updated on 3-Apr-2024

Summary

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Official Symbol
Qtrt2provided by MGI
Official Full Name
queuine tRNA-ribosyltransferase accessory subunit 2provided by MGI
Primary source
MGI:MGI:1922194
See related
Ensembl:ENSMUSG00000022704 AllianceGenome:MGI:1922194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qrtr2; Qtrtd1; 3110012M05Rik; 4930470H18Rik
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to contribute to queuine tRNA-ribosyltransferase activity. Involved in tRNA-guanine transglycosylation. Located in mitochondrion. Part of protein-containing complex. Orthologous to human QTRT2 (queuine tRNA-ribosyltransferase accessory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 12.0), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 28.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43681879..43710063, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43861407..43889797, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene dopamine receptor D3 Neighboring gene STARR-seq mESC enhancer starr_40887 Neighboring gene predicted gene, 26074 Neighboring gene STARR-seq mESC enhancer starr_40888 Neighboring gene STARR-positive B cell enhancer ABC_E1924 Neighboring gene predicted gene, 25989 Neighboring gene coiled-coil domain containing 191 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43951746-43952047 Neighboring gene zinc finger, DHHC domain containing 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase. Behrens C, et al. Biochemistry, 2018 Jul 3. PMID 29862811
  2. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Sebastiani M, et al. ACS Chem Biol, 2022 Aug 19. PMID 35815944
  3. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. Boland C, et al. J Biol Chem, 2009 Jul 3. PMID 19414587, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
    Title: Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
  2. In the crystal, QTRT2 is clearly present as a homodimer that is strikingly similar to that formed by bacterial TGT. In particular, a cluster of four aromatic residues within the interface of the bacterial TGT, which constitutes a "hot spot" for dimer stability, is present in a similar constellation in QTRT2.
    Title: Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase.
  3. TGT weakly interacts with the outer mitochondrial membrane possibly through association with Qv1(QTRD1 variant 1), which was found to be stably associated with the organelle
    Title: Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102598

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA-guanine transglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA-guanine transglycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA-guanine transglycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
queuine tRNA-ribosyltransferase accessory subunit 2
Names
queuine tRNA-ribosyltransferase domain containing 1
queuine tRNA-ribosyltransferase domain-containing protein 1
queuine tRNA-ribosyltransferase subunit QTRTD1
NP_001343257.1
NP_001343258.2
NP_001392345.1
NP_001392346.1
NP_001392347.1
NP_083404.3
XP_006521733.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356328.2 → NP_001343257.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025520
    Conserved Domains (1) summary
    pfam01702
    Location:48 → 322
    TGT; Queuine tRNA-ribosyltransferase

  2. NM_001356329.4 → NP_001343258.2  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT025520
    Consensus CDS
    CCDS88930.1
    UniProtKB/Swiss-Prot
    A9C446, B8ZXI1, Q5XK35
    Related
    ENSMUSP00000158885.2, ENSMUST00000239112.2

  3. NM_001405416.1 → NP_001392345.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025520

  4. NM_001405417.1 → NP_001392346.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025520

  5. NM_001405418.1 → NP_001392347.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025520

  6. NM_029128.5 → NP_083404.3  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT025520
    Consensus CDS
    CCDS37344.1
    Related
    ENSMUSP00000023387.8, ENSMUST00000023387.14

RNA

  1. NR_175937.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT025520
    Related
    ENSMUST00000156568.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    43681879..43710063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521670.5 → XP_006521733.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006521733.1

    UniProtKB/TrEMBL
    A0A5F8MPN7, Z4YJE9
    Conserved Domains (1) summary
    pfam01702
    Location:14 → 416
    TGT; Queuine tRNA-ribosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B8ZXI1.2 GenPept UniProtKB/Swiss-Prot:B8ZXI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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