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Zc3h7a zinc finger CCCH type containing 7 A [ Mus musculus (house mouse) ]

Gene ID: 106205, updated on 5-Mar-2024

Summary

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Official Symbol
Zc3h7aprovided by MGI
Official Full Name
zinc finger CCCH type containing 7 Aprovided by MGI
Primary source
MGI:MGI:2445044
See related
Ensembl:ENSMUSG00000037965 AllianceGenome:MGI:2445044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zc3h7; HSPC055; Zc3hdc7; A430104C18Rik
Summary
Predicted to enable miRNA binding activity. Predicted to be involved in production of miRNAs involved in gene silencing by miRNA. Is expressed in Meckel's cartilage; embryo mesenchyme; and skeleton. Orthologous to human ZC3H7A (zinc finger CCCH-type containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 21.0), limb E14.5 (RPKM 20.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 6.35 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10954458..10994257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11136594..11176393, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9861 Neighboring gene STARR-positive B cell enhancer ABC_E9926 Neighboring gene STARR-positive B cell enhancer ABC_E10889 Neighboring gene nonconserved acetylation island sequence M94 enhancer Neighboring gene stannin Neighboring gene thioredoxin domain containing 11 Neighboring gene RIKEN cDNA 4930509G22 gene Neighboring gene predicted gene, 24145 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene Wdr45 like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. Liang J, et al. PLoS One, 2008 Aug 6. PMID 18682727, Free PMC Article
  2. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 7A
Names
zinc finger CCCH type domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145931.3 → NP_666043.2  zinc finger CCCH domain-containing protein 7A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AK040507, AK150952, AV228180
    Consensus CDS
    CCDS49762.1
    UniProtKB/TrEMBL
    E9PWW6, Q3UBH9
    Related
    ENSMUSP00000041308.10, ENSMUST00000037633.16
    Conserved Domains (4) summary
    TIGR00990
    Location:6 → 169
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:858 → 880
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:856 → 881
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RNA

  1. NR_027502.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK040507, AK150952, BY297607, CJ302186

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10954458..10994257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521665.4 → XP_006521728.2  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    E9PWW6, Q3UBH9
    Conserved Domains (4) summary
    TIGR00990
    Location:6 → 169
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:858 → 880
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:856 → 881
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  2. XM_006521664.4 → XP_006521727.2  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    E9PWW6, Q3UBH9
    Conserved Domains (4) summary
    TIGR00990
    Location:6 → 169
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:858 → 880
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:856 → 881
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  3. XM_006521666.3 → XP_006521729.2  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    E9PWW6, Q3UBH9
    Conserved Domains (4) summary
    TIGR00990
    Location:6 → 169
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:858 → 880
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:856 → 881
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RNA

  1. XR_004939142.1 RNA Sequence

  2. XR_004939143.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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