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STAMBP STAM binding protein [ Homo sapiens (human) ]

Gene ID: 10617, updated on 11-Apr-2024

Summary

Official Symbol
STAMBPprovided by HGNC
Official Full Name
STAM binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16950
See related
Ensembl:ENSG00000124356 MIM:606247; AllianceGenome:HGNC:16950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMSH; MICCAP
Summary
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 4.9), brain (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

Location:
2p13.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73828961..73873656)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73837148..73881820)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74056088..74100783)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16034 Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74055859-74056077 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:74057585-74058784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16035 Neighboring gene uncharacterized LOC112268419 Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74119211-74120024 Neighboring gene actin gamma 2, smooth muscle Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74139533-74139680

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126516, MGC126518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal-dependent deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
STAM-binding protein
Names
associated molecule with the SH3 domain of STAM
endosome-associated ubiquitin isopeptidase
testicular secretory protein Li 54
NP_001340896.1
NP_001340897.1
NP_001340898.1
NP_001340899.1
NP_001340900.1
NP_001340901.1
NP_001340902.1
NP_001340903.1
NP_001340904.1
NP_001340905.1
NP_006454.1
NP_964010.1
NP_998787.1
XP_011530787.1
XP_047298917.1
XP_047298918.1
XP_047298919.1
XP_047298920.1
XP_047298924.1
XP_047298926.1
XP_047298927.1
XP_047298928.1
XP_047298929.1
XP_047298930.1
XP_054196176.1
XP_054196177.1
XP_054196178.1
XP_054196179.1
XP_054196180.1
XP_054196181.1
XP_054196182.1
XP_054196183.1
XP_054196184.1
XP_054196185.1
XP_054196186.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033223.2 RefSeqGene

    Range
    5051..43258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001353967.2NP_001340896.1  STAM-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54, A0A804HJS0
    Related
    ENSP00000507054.1, ENST00000684585.1
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  2. NM_001353968.2NP_001340897.1  STAM-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54, A0A804HJS0
    Related
    ENSP00000506833.1, ENST00000682351.1
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  3. NM_001353969.2NP_001340898.1  STAM-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS92778.1
    UniProtKB/TrEMBL
    A0A804HII8, A0A804HKA6
    Related
    ENSP00000507807.1, ENST00000683349.1
    Conserved Domains (2) summary
    cd08066
    Location:254405
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  4. NM_001353970.2NP_001340899.1  STAM-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS92778.1
    UniProtKB/TrEMBL
    A0A804HII8, A0A804HKA6
    Related
    ENSP00000507089.1, ENST00000682799.1
    Conserved Domains (2) summary
    cd08066
    Location:254405
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  5. NM_001353971.2NP_001340900.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS92779.1
    UniProtKB/TrEMBL
    A0A804HJ64
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  6. NM_001353972.2NP_001340901.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS92779.1
    UniProtKB/TrEMBL
    A0A804HJ64
    Related
    ENSP00000507371.1, ENST00000682851.1
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  7. NM_001353973.2NP_001340902.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS92779.1
    UniProtKB/TrEMBL
    A0A804HJ64
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  8. NM_001353974.2NP_001340903.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS92779.1
    UniProtKB/TrEMBL
    A0A804HJ64
    Related
    ENST00000683465.1
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  9. NM_001353975.2NP_001340904.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS92779.1
    UniProtKB/TrEMBL
    A0A804HJ64
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  10. NM_001353976.2NP_001340905.1  STAM-binding protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (1) summary
    cd08066
    Location:119270
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  11. NM_006463.6NP_006454.1  STAM-binding protein isoform 1

    See identical proteins and their annotated locations for NP_006454.1

    Status: REVIEWED

    Source sequence(s)
    AC073046, BC101467, DB477012, DR158757
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54, A0A804HJS0
    Related
    ENSP00000377636.1, ENST00000394073.6
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  12. NM_201647.4NP_964010.1  STAM-binding protein isoform 1

    See identical proteins and their annotated locations for NP_964010.1

    Status: REVIEWED

    Source sequence(s)
    AC073046, DN919763, U73522
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54, A0A804HJS0
    Related
    ENSP00000344742.3, ENST00000339566.7
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  13. NM_213622.4NP_998787.1  STAM-binding protein isoform 1

    See identical proteins and their annotated locations for NP_998787.1

    Status: REVIEWED

    Source sequence(s)
    AC073046, BC065574, CX758449
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54, A0A804HJS0
    Related
    ENSP00000377633.2, ENST00000394070.7
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain

RNA

  1. NR_148668.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046
  2. NR_148669.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Related
    ENST00000478946.2
  3. NR_148670.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046
  4. NR_148671.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Related
    ENST00000683417.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    73828961..73873656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442964.1XP_047298920.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000506958.1, ENST00000684312.1
  2. XM_047442961.1XP_047298917.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  3. XM_047442970.1XP_047298926.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  4. XM_047442971.1XP_047298927.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000507081.1, ENST00000682379.1
  5. XM_047442963.1XP_047298919.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  6. XM_047442962.1XP_047298918.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000507864.1, ENST00000682847.1
  7. XM_047442968.1XP_047298924.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000386548.1, ENST00000409707.6
  8. XM_047442974.1XP_047298930.1  STAM-binding protein isoform X3

    UniProtKB/TrEMBL
    A0A804HJ64
  9. XM_011532485.4XP_011530787.1  STAM-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A804HI64, A0A804HIF8
    Conserved Domains (2) summary
    pfam08969
    Location:13114
    USP8_dimer; USP8 dimerization domain
    cl13996
    Location:254335
    MPN; Mpr1p, Pad1p N-terminal (MPN) domains
  10. XM_047442973.1XP_047298929.1  STAM-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A804HIF8
    Related
    ENSP00000507046.1, ENST00000682998.1
  11. XM_047442972.1XP_047298928.1  STAM-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A804HIF8
    Related
    ENSP00000413874.3, ENST00000432295.7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    73837148..73881820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340204.1XP_054196179.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  2. XM_054340201.1XP_054196176.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  3. XM_054340203.1XP_054196178.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  4. XM_054340202.1XP_054196177.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  5. XM_054340206.1XP_054196181.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  6. XM_054340207.1XP_054196182.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  7. XM_054340205.1XP_054196180.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B5M0B6, D6W5H7, O95630, Q3MJE7
    UniProtKB/TrEMBL
    A0A140VK54
  8. XM_054340211.1XP_054196186.1  STAM-binding protein isoform X3

    UniProtKB/TrEMBL
    A0A804HJ64
  9. XM_054340208.1XP_054196183.1  STAM-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A804HIF8
  10. XM_054340210.1XP_054196185.1  STAM-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A804HIF8
  11. XM_054340209.1XP_054196184.1  STAM-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A804HIF8