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Slc45a4 solute carrier family 45, member 4 [ Mus musculus (house mouse) ]

Gene ID: 106068, updated on 11-Apr-2024

Summary

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Official Symbol
Slc45a4provided by MGI
Official Full Name
solute carrier family 45, member 4provided by MGI
Primary source
MGI:MGI:2146236
See related
Ensembl:ENSMUSG00000079020 AllianceGenome:MGI:2146236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9330175B01Rik
Summary
Enables sucrose:proton symporter activity. Acts upstream of or within sucrose transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in central nervous system and retina. Orthologous to human SLC45A4 (solute carrier family 45 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.9), ovary adult (RPKM 14.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc45a4 in Genome Data Viewer
Location:
15 D3; 15 34.02 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (73449267..73517606, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (73577418..73645757, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:73342795-73343096 Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial pseudogene Neighboring gene DENN domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_38965 Neighboring gene STARR-positive B cell enhancer mm9_chr15:73476060-73476361 Neighboring gene STARR-seq mESC enhancer starr_38967 Neighboring gene STARR-seq mESC enhancer starr_38972 Neighboring gene G protein-coupled receptor 20 Neighboring gene STARR-positive B cell enhancer mm9_chr15:73548453-73548754 Neighboring gene protein tyrosine phosphatase 4a3 Neighboring gene predicted gene, 22106

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain. Suenkel C, et al. Cell Rep, 2020 Feb 18. PMID 32075758
  2. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
  3. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  4. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sucrose:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sucrose:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within sucrose transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 45 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033219.4 → NP_001028391.2  solute carrier family 45 member 4 isoform 1

    See identical proteins and their annotated locations for NP_001028391.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC119914
    Consensus CDS
    CCDS27517.1
    UniProtKB/Swiss-Prot
    Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
    UniProtKB/TrEMBL
    F7BEQ1
    Related
    ENSMUSP00000121775.2, ENSMUST00000151288.8
    Conserved Domains (1) summary
    cl28910
    Location:53 → 275
    MFS; Major Facilitator Superfamily

  2. NM_001168255.2 → NP_001161727.1  solute carrier family 45 member 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC119914
    Consensus CDS
    CCDS49632.1
    UniProtKB/TrEMBL
    F7BEQ1
    Related
    ENSMUSP00000115827.2, ENSMUST00000132607.2
    Conserved Domains (1) summary
    cd06174
    Location:386 → 537
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. NM_001357747.1 → NP_001344676.1  solute carrier family 45 member 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC119914
    Consensus CDS
    CCDS27517.1
    UniProtKB/Swiss-Prot
    Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
    UniProtKB/TrEMBL
    F7BEQ1
    Related
    ENSMUSP00000075577.6, ENSMUST00000076224.12
    Conserved Domains (1) summary
    cl28910
    Location:53 → 275
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    73449267..73517606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245401.1 → XP_011243703.1  solute carrier family 45 member 4 isoform X1

    See identical proteins and their annotated locations for XP_011243703.1

    UniProtKB/Swiss-Prot
    Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
    UniProtKB/TrEMBL
    F7BEQ1
    Conserved Domains (1) summary
    cl28910
    Location:53 → 275
    MFS; Major Facilitator Superfamily

  2. XM_017316363.3 → XP_017171852.1  solute carrier family 45 member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
    UniProtKB/TrEMBL
    F7BEQ1
    Conserved Domains (1) summary
    cl28910
    Location:53 → 275
    MFS; Major Facilitator Superfamily

  3. XM_030248266.2 → XP_030104126.1  solute carrier family 45 member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
    UniProtKB/TrEMBL
    F7BEQ1
    Conserved Domains (1) summary
    cl28910
    Location:53 → 275
    MFS; Major Facilitator Superfamily

  4. XM_017316364.3 → XP_017171853.1  solute carrier family 45 member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
    UniProtKB/TrEMBL
    F7BEQ1
    Conserved Domains (1) summary
    cl28910
    Location:53 → 275
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P5V9.1 GenPept UniProtKB/Swiss-Prot:Q0P5V9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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