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Tafa5 TAFA chemokine like family member 5 [ Mus musculus (house mouse) ]

Gene ID: 106014, updated on 11-Apr-2024

Summary

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Official Symbol
Tafa5provided by MGI
Official Full Name
TAFA chemokine like family member 5provided by MGI
Primary source
MGI:MGI:2146182
See related
Ensembl:ENSMUSG00000054863 AllianceGenome:MGI:2146182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tafa-5; Tara-5; Fam19a5
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Biased expression in frontal lobe adult (RPKM 18.4), cerebellum adult (RPKM 17.8) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 42.1 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (87428405..87643565)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (87544219..87759364)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39425 Neighboring gene predicted gene, 35422 Neighboring gene predicted gene, 35471 Neighboring gene STARR-seq mESC enhancer starr_39426 Neighboring gene STARR-seq mESC enhancer starr_39427 Neighboring gene microRNA 6393 Neighboring gene predicted gene, 35599 Neighboring gene predicted gene, 35711

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Brain-specific chemokine FAM19A5 induces hypothalamic inflammation. Kang D, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31954515
  2. FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. Park MY, et al. Sci Rep, 2017 Nov 14. PMID 29138422, Free PMC Article
  3. FAM19A5 Expression During Embryogenesis and in the Adult Traumatic Brain of FAM19A5-LacZ Knock-in Mice. Shahapal A, et al. Front Neurosci, 2019. PMID 31543758, Free PMC Article
  4. Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Ramalingam H, et al. Dev Biol, 2018 Aug 1. PMID 29705331, Free PMC Article
  5. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Tom Tang Y, et al. Genomics, 2004 Apr. PMID 15028294

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain-specific chemokine FAM19A5 induces hypothalamic inflammation.
    Title: Brain-specific chemokine FAM19A5 induces hypothalamic inflammation.
  2. Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling.
    Title: Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.
  3. our results suggest that FAM19A5 and its target receptor FPR2 can act as novel endogenous ligand/receptor to negatively regulate osteoclastogenesis. They might be regarded as potential targets to control osteoclast formation and bone disorders.
    Title: FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
chemokine-like protein TAFA-5
Names
family with sequence similarity 19, member A5
protein FAM19A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252310.1 → NP_001239239.1  chemokine-like protein TAFA-5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001239239.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123925, AK090194, BE945208, BU057253, BY733542
    Consensus CDS
    CCDS88823.1
    UniProtKB/Swiss-Prot
    Q8C1V6, Q91WE9
    Related
    ENSMUSP00000155322.2, ENSMUST00000230414.2
    Conserved Domains (1) summary
    pfam12020
    Location:42 → 131
    TAFA; TAFA family

  2. NM_134096.2 → NP_598857.1  chemokine-like protein TAFA-5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_598857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC123925, AY325124, BE945208
    Consensus CDS
    CCDS49693.1
    UniProtKB/Swiss-Prot
    Q91WE9
    Related
    ENSMUSP00000064808.7, ENSMUST00000068088.8
    Conserved Domains (1) summary
    pfam12020
    Location:35 → 124
    TAFA; TAFA family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    87428405..87643565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520262.3 → XP_006520325.1  chemokine-like protein TAFA-5 isoform X3

    Conserved Domains (1) summary
    pfam12020
    Location:42 → 90
    TAFA; TAFA family

  2. XM_006520260.4 → XP_006520323.1  chemokine-like protein TAFA-5 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:42 → 131
    TAFA; TAFA family

  3. XM_006520261.4 → XP_006520324.1  chemokine-like protein TAFA-5 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:35 → 124
    TAFA; TAFA family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_045510.1: Suppressed sequence

    Description
    NR_045510.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WE9.2 GenPept UniProtKB/Swiss-Prot:Q91WE9

Gene LinkOut

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