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Krt72 keratin 72 [ Mus musculus (house mouse) ]

Gene ID: 105866, updated on 11-Apr-2024

Summary

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Official Symbol
Krt72provided by MGI
Official Full Name
keratin 72provided by MGI
Primary source
MGI:MGI:2146034
See related
Ensembl:ENSMUSG00000056605 AllianceGenome:MGI:2146034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K72; CK-72; K6irs2; Krt2-35; Krt72-ps
Summary
Predicted to be located in keratin filament. Is expressed in vibrissa. Orthologous to human KRT72 (keratin 72). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
15 F2; 15 57.02 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101684607..101694955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101776172..101786520, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 71 Neighboring gene keratin 74 Neighboring gene STARR-seq mESC enhancer starr_39803 Neighboring gene STARR-seq mESC enhancer starr_39804 Neighboring gene keratin 73 Neighboring gene keratin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. Blanco S, et al. PLoS Genet, 2011 Dec. PMID 22144916, Free PMC Article
  2. iRhom2 mutation leads to aberrant hair follicle differentiation in mice. Leilei Y, et al. PLoS One, 2014. PMID 25546423, Free PMC Article
  3. Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion. Sardella C, et al. J Invest Dermatol, 2018 Mar. PMID 28964716, Free PMC Article
  4. Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Wu X, et al. Genes Dev, 2006 Mar 1. PMID 16510873, Free PMC Article
  5. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
keratin, type II cytoskeletal 72
Names
cytokeratin-72
keratin 72, pseudogene
keratin complex 2, basic, gene 35
type II inner root sheath-specific keratin-K6irs2
type-II keratin Kb35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213728.2 → NP_998893.1  keratin, type II cytoskeletal 72

    See identical proteins and their annotated locations for NP_998893.1

    Status: VALIDATED

    Source sequence(s)
    AA717861, AC104862, BK001584
    Consensus CDS
    CCDS27863.1
    UniProtKB/Swiss-Prot
    Q6IME9
    Related
    ENSMUSP00000065922.5, ENSMUST00000071104.6
    Conserved Domains (4) summary
    pfam00038
    Location:133 → 446
    Filament; Intermediate filament protein
    pfam05098
    Location:184 → 313
    LEF-4; Late expression factor 4 (LEF-4)
    pfam16208
    Location:15 → 130
    Keratin_2_head; Keratin type II head
    cl09176
    Location:300 → 429
    FlgN; FlgN protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101684607..101694955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IME9.1 GenPept UniProtKB/Swiss-Prot:Q6IME9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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