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Lmf2 lipase maturation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 105847, updated on 11-Apr-2024

Summary

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Official Symbol
Lmf2provided by MGI
Official Full Name
lipase maturation factor 2provided by MGI
Primary source
MGI:MGI:2146015
See related
Ensembl:ENSMUSG00000022614 AllianceGenome:MGI:2146015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem153; Tmem112b
Summary
Predicted to be involved in protein maturation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human LMF2 (lipase maturation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 40.6), lung adult (RPKM 35.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 44.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89235203..89239860, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89351004..89355694, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene adrenomedullin 2 Neighboring gene STARR-seq mESC enhancer starr_39462 Neighboring gene myo-inositol oxygenase Neighboring gene STARR-positive B cell enhancer ABC_E7405 Neighboring gene STARR-positive B cell enhancer ABC_E3152 Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene STARR-seq mESC enhancer starr_39464 Neighboring gene SCO2 cytochrome c oxidase assembly protein Neighboring gene thymidine phosphorylase Neighboring gene ciliary microtubule associated protein 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipase maturation factor 2
Names
transmembrane protein 112B
transmembrane protein 153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416186.1 → NP_001403115.1  lipase maturation factor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113976

  2. NM_001416187.1 → NP_001403116.1  lipase maturation factor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113976

  3. NM_001416188.1 → NP_001403117.1  lipase maturation factor 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113976

  4. NM_001416189.1 → NP_001403118.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976
    Related
    ENSMUST00000230112.2

  5. NM_001416190.1 → NP_001403119.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  6. NM_001416191.1 → NP_001403120.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  7. NM_001416192.1 → NP_001403121.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  8. NM_001416193.1 → NP_001403122.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  9. NM_001416194.1 → NP_001403123.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  10. NM_001416195.1 → NP_001403124.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  11. NM_001416196.1 → NP_001403125.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  12. NM_001416197.1 → NP_001403126.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  13. NM_001416198.1 → NP_001403127.1  lipase maturation factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113976

  14. NM_001416199.1 → NP_001403128.1  lipase maturation factor 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113976

  15. NM_178919.5 → NP_849250.1  lipase maturation factor 2 isoform 1

    See identical proteins and their annotated locations for NP_849250.1

    Status: VALIDATED

    Source sequence(s)
    AC113976
    Consensus CDS
    CCDS27746.1
    UniProtKB/Swiss-Prot
    Q8C3X8
    Related
    ENSMUSP00000023283.6, ENSMUST00000023283.6
    Conserved Domains (1) summary
    pfam06762
    Location:127 → 587
    LMF1; Lipase maturation factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89235203..89239860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159059.1 → XP_036014952.1  lipase maturation factor 2 isoform X1

    Conserved Domains (1) summary
    pfam06762
    Location:1 → 410
    LMF1; Lipase maturation factor

  2. XM_036159060.1 → XP_036014953.1  lipase maturation factor 2 isoform X1

    Related
    ENSMUST00000231067.2
    Conserved Domains (1) summary
    pfam06762
    Location:1 → 410
    LMF1; Lipase maturation factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C3X8.1 GenPept UniProtKB/Swiss-Prot:Q8C3X8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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