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Sgsm3 small G protein signaling modulator 3 [ Mus musculus (house mouse) ]

Gene ID: 105835, updated on 30-Apr-2024

Summary

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Official Symbol
Sgsm3provided by MGI
Official Full Name
small G protein signaling modulator 3provided by MGI
Primary source
MGI:MGI:1916329
See related
Ensembl:ENSMUSG00000042303 AllianceGenome:MGI:1916329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cip85; RUSC3; Rutbc3; 1810012I01Rik
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in positive regulation of protein catabolic process. Located in gap junction. Is expressed in several structures, including central nervous system; ear; ganglia; lung; and submandibular gland primordium. Orthologous to human SGSM3 (small G protein signaling modulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 44.3), testis adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.96 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80861966..80896491)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80977762..81012290)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing 6b Neighboring gene STARR-seq mESC enhancer starr_39246 Neighboring gene microRNA 5113 Neighboring gene predicted gene 6612 Neighboring gene adenylosuccinate lyase Neighboring gene STARR-seq mESC enhancer starr_39247 Neighboring gene predicted gene, 31462 Neighboring gene myocardin related transcription factor A Neighboring gene predicted gene, 25131 Neighboring gene STARR-seq mESC enhancer starr_39250 Neighboring gene RIKEN cDNA 4930483J18 gene Neighboring gene STARR-positive B cell enhancer ABC_E943

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Small G protein signaling modulator 3 (SGSM3) knockdown attenuates apoptosis and cardiogenic differentiation in rat mesenchymal stem cells exposed to hypoxia. Jung SE, et al. PLoS One, 2020. PMID 32271805, Free PMC Article
  2. Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Lan Z, et al. Biochemistry, 2005 Feb 22. PMID 15709751, Free PMC Article
  3. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Yang H, et al. Genomics, 2007 Aug. PMID 17509819
  4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
  5. RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Hüttenhofer A, et al. EMBO J, 2001 Jun 1. PMID 11387227, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables GTPase regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in plasma membrane to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in gap junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small G protein signaling modulator 3
Names
Cx43-interacting protein of 85-kDa
RUN and TBC1 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357669.1 → NP_001344598.1  small G protein signaling modulator 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC141880
    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:409 → 461
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:114 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:488 → 639
    RUN; RUN domain

  2. NM_134091.2 → NP_598852.3  small G protein signaling modulator 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI844026, AK142314, BC018197, BY242851
    Consensus CDS
    CCDS49673.2
    UniProtKB/Swiss-Prot
    Q3TCB6, Q8VCZ6
    UniProtKB/TrEMBL
    A0A2R8VI76
    Related
    ENSMUSP00000122543.2, ENSMUST00000139517.9
    Conserved Domains (3) summary
    cd11813
    Location:484 → 536
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:114 → 325
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:563 → 717
    RUN; RUN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    80861966..80896491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520249.5 → XP_006520312.1  small G protein signaling modulator 3 isoform X3

    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:495 → 547
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:125 → 336
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:574 → 725
    RUN; RUN domain

  2. XM_006520244.5 → XP_006520307.1  small G protein signaling modulator 3 isoform X1

    See identical proteins and their annotated locations for XP_006520307.1

    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:495 → 547
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:125 → 336
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:574 → 725
    RUN; RUN domain

  3. XM_030248261.2 → XP_030104121.1  small G protein signaling modulator 3 isoform X4

    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:494 → 546
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:124 → 335
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:573 → 724
    RUN; RUN domain

  4. XM_017316358.3 → XP_017171847.1  small G protein signaling modulator 3 isoform X5

    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:318 → 370
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    pfam00566
    Location:11 → 159
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam02759
    Location:397 → 548
    RUN; RUN domain

  5. XM_006520245.5 → XP_006520308.1  small G protein signaling modulator 3 isoform X1

    See identical proteins and their annotated locations for XP_006520308.1

    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:495 → 547
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:125 → 336
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:574 → 725
    RUN; RUN domain

  6. XM_006520247.5 → XP_006520310.1  small G protein signaling modulator 3 isoform X2

    See identical proteins and their annotated locations for XP_006520310.1

    UniProtKB/TrEMBL
    A0A2R8VI76
    Related
    ENSMUSP00000155794.2, ENSMUST00000124845.9
    Conserved Domains (3) summary
    cd11813
    Location:494 → 546
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:124 → 335
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:573 → 724
    RUN; RUN domain

  7. XM_006520246.5 → XP_006520309.1  small G protein signaling modulator 3 isoform X1

    See identical proteins and their annotated locations for XP_006520309.1

    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:495 → 547
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:125 → 336
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:574 → 725
    RUN; RUN domain

  8. XM_006520248.5 → XP_006520311.1  small G protein signaling modulator 3 isoform X2

    See identical proteins and their annotated locations for XP_006520311.1

    UniProtKB/TrEMBL
    A0A2R8VI76
    Conserved Domains (3) summary
    cd11813
    Location:494 → 546
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:124 → 335
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:573 → 724
    RUN; RUN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCZ6.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ6

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