Ccdc65 coiled-coil domain containing 65 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccdc65provided by MGI
Official Full Name: coiled-coil domain containing 65provided by MGI
Primary source: MGI:MGI:2146001
See related: Ensembl:ENSMUSG00000003354 AllianceGenome:MGI:2146001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NYD-SP28; 4933417K04Rik
Summary: Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be located in ciliary basal body. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in 4th ventricle lateral recess; diencephalon roof plate; lateral ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 27. Orthologous to human CCDC65 (coiled-coil domain containing 65). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 72.0) and ovary adult (RPKM 3.0) See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.65 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98606075..98621221)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98708194..98723340)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
Title: CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
Ccdc65 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136372 (e-PCR)
- UniSTS:210362

PMC128323P1 (e-PCR)
- UniSTS:270576

AI428139 (e-PCR)
- UniSTS:160504

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium-dependent cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cilium movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cilium movement	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of axonemal dynein complex	IEA Inferred from Electronic Annotation more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein regulatory complex subunit 2

Names: coiled-coil domain-containing protein 65; testis development protein NYD-SP28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.