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SORBS1 sorbin and SH3 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 10580, updated on 7-Apr-2024

Summary

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Official Symbol
SORBS1provided by HGNC
Official Full Name
sorbin and SH3 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:14565
See related
Ensembl:ENSG00000095637 MIM:605264; AllianceGenome:HGNC:14565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12
Summary
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Broad expression in fat (RPKM 111.7), heart (RPKM 81.6) and 15 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.1
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (95311773..95561371, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (96190944..96440561, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97071530..97321128, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984257 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:96961907-96962201 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96987152-96987893 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96988638-96989207 Neighboring gene Sharpr-MPRA regulatory region 8644 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr10:96990347-96990915 and GRCh37_chr10:96990916-96991485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:97000971-97001634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:97001635-97002298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3792 Neighboring gene acyl-CoA synthetase medium chain family member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3793 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:97020155-97020844 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:97024067-97024842 Neighboring gene PDZ and LIM domain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3795 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:97054719-97055315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3798 Neighboring gene CRISPRi-validated cis-regulatory element chr10.3436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3799 Neighboring gene Sharpr-MPRA regulatory region 12220 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:97106670-97107322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:97190228-97190728 Neighboring gene Sharpr-MPRA regulatory region 10569 Neighboring gene VISTA enhancer hs2353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:97291131-97291878 Neighboring gene NANOG hESC enhancer GRCh37_chr10:97299485-97299986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:97311480-97312414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:97320711-97321473 Neighboring gene Sharpr-MPRA regulatory region 13709 Neighboring gene Sharpr-MPRA regulatory region 3716 Neighboring gene RPS3A pseudogene 36 Neighboring gene aldehyde dehydrogenase 18 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2649

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population. Gong S, et al. Diabetes Metab Res Rev, 2022 Jul. PMID 35107206
  2. Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study. Chang TJ, et al. Sci Rep, 2018 Jul 12. PMID 30002559, Free PMC Article
  3. SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug. Song L, et al. Oncotarget, 2017 Feb 7. PMID 27791200, Free PMC Article
  4. Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study. Chang TJ, et al. Medicine (Baltimore), 2016 Mar. PMID 26962801, Free PMC Article
  5. SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes. Germain M, et al. Diabetologia, 2015 Mar. PMID 25476525, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased serum extrachromosomal circular DNA SORBS1[circle] level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus.
    Title: Increased serum extrachromosomal circular DNA SORBS1(circle) level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus.
  2. Down-regulation and clinical significance of Sorbin and SH3 domain-containing protein 1 in bladder cancer tissues.
    Title: Down-regulation and clinical significance of Sorbin and SH3 domain-containing protein 1 in bladder cancer tissues.
  3. MiR-223-3p increases resistance of colorectal cancer cells to 5-fluorouracil via targeting SORBS1.
    Title: MiR-223-3p increases resistance of colorectal cancer cells to 5-fluorouracil via targeting SORBS1.
  4. A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population.
    Title: A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population.
  5. MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway.
    Title: MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway.
  6. Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.
    Title: Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.
  7. SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines.
    Title: SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines.
  8. The SORBS1 GG genotype of rs2281939 was associated with a higher risk of diabetes at baseline, an earlier onset of diabetes, and higher steady-state plasma glucose levels in the modified insulin suppression test. The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test in Chinese patients.
    Title: Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study.
  9. SORBS1 suppresses tumor metastasis and improves the sensitivity of breast cancer cells to antineoplastic agents.
    Title: SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug.
  10. association between common SORBS1 genetic variations and blood pressure, presence of hypertension, and age at onset of hypertension
    Title: Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of suicide attempts in mood disorder patients.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced downregulation of sorbin and SH3 domain containing 1 (SORBS1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12406, KIAA1296, DKFZp451C066, DKFZp586P1422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables cytoskeletal protein binding TAS
Traceable Author Statement
more info
 PubMed 
enables insulin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor complex adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor complex adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-matrix adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell-substrate adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell-substrate junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-substrate junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of flotillin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in zonula adherens TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
sorbin and SH3 domain-containing protein 1
Names
Fas-ligand associated factor 2
SH3 domain protein 5
c-Cbl associated protein
ponsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034041.2 RefSeqGene

    Range
    5000..254598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001034954.3 → NP_001030126.2  sorbin and SH3 domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS31255.1
    UniProtKB/Swiss-Prot
    A0AED4, A6NEK3, A6NID8, A6NJS4, A7MD40, D3DR42, O43857, Q5T923, Q5T924, Q5T927, Q5T928, Q5T929, Q5T930, Q5T931, Q5T932, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9BX66, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338
    Related
    ENSP00000360293.2, ENST00000371247.7
    Conserved Domains (4) summary
    cd11916
    Location:1233 → 1291
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:796 → 850
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:870 → 927
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:370 → 411
    Sorb; Sorbin homologous domain

  2. NM_001034955.2 → NP_001030127.2  sorbin and SH3 domain-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL158165
    Consensus CDS
    CCDS31254.1
    Related
    ENSP00000277982.5, ENST00000277982.9
    Conserved Domains (4) summary
    cd11916
    Location:1092 → 1150
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:818 → 872
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:892 → 949
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:370 → 411
    Sorb; Sorbin homologous domain

  3. NM_001034956.2 → NP_001030128.2  sorbin and SH3 domain-containing protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL158165
    Consensus CDS
    CCDS31256.1
    UniProtKB/TrEMBL
    A0A3B3IT56
    Related
    ENSP00000360291.2, ENST00000371245.7
    Conserved Domains (4) summary
    cd11916
    Location:846 → 904
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:647 → 701
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:721 → 778
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:301 → 342
    Sorb; Sorbin homologous domain

  4. NM_001034957.3 → NP_001030129.2  sorbin and SH3 domain-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (5) summary
    cd11916
    Location:681 → 739
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:502 → 556
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:576 → 633
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    COG5665
    Location:41 → 327
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    cl02617
    Location:206 → 247
    Sorb; Sorbin homologous domain

  5. NM_001290294.2 → NP_001277223.2  sorbin and SH3 domain-containing protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS73169.1
    Related
    ENSP00000360271.3, ENST00000371227.8
    Conserved Domains (4) summary
    smart00459
    Location:367 → 412
    Sorb; Sorbin homologous domain
    cd11916
    Location:1207 → 1265
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:750 → 804
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:824 → 881
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

  6. NM_001290295.2 → NP_001277224.2  sorbin and SH3 domain-containing protein 1 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. The encoded protein (isoform 9) is shorter than isoform 3.
    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Related
    ENSP00000496969.2, ENST00000647619.2
    Conserved Domains (5) summary
    smart00459
    Location:212 → 257
    Sorb; Sorbin homologous domain
    cd11916
    Location:690 → 748
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:511 → 565
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:585 → 642
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam15449
    Location:51 → 209
    Retinal; Retinal protein

  7. NM_001290296.2 → NP_001277225.2  sorbin and SH3 domain-containing protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL158165
    Consensus CDS
    CCDS76327.1
    Related
    ENSP00000277984.4, ENST00000354106.7

  8. NM_001290297.3 → NP_001277226.2  sorbin and SH3 domain-containing protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS76326.1
    UniProtKB/TrEMBL
    A0A3B3IT56
    Conserved Domains (4) summary
    smart00459
    Location:212 → 257
    Sorb; Sorbin homologous domain
    cd11916
    Location:752 → 810
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:573 → 627
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:647 → 704
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

  9. NM_001290298.3 → NP_001277227.2  sorbin and SH3 domain-containing protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:787 → 845
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:608 → 662
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:682 → 739
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:238 → 279
    Sorb; Sorbin homologous domain

  10. NM_001377197.1 → NP_001364126.1  sorbin and SH3 domain-containing protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    A0A3B3IT56
    Conserved Domains (4) summary
    cd11916
    Location:889 → 947
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:710 → 764
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:784 → 841
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:361 → 402
    Sorb; Sorbin homologous domain

  11. NM_001377198.1 → NP_001364127.1  sorbin and SH3 domain-containing protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:866 → 924
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:687 → 741
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:761 → 818
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:338 → 379
    Sorb; Sorbin homologous domain

  12. NM_001377199.1 → NP_001364128.1  sorbin and SH3 domain-containing protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:845 → 903
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:666 → 720
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:740 → 797
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:370 → 411
    Sorb; Sorbin homologous domain

  13. NM_001377200.1 → NP_001364129.1  sorbin and SH3 domain-containing protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:841 → 899
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:662 → 716
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:736 → 793
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:338 → 379
    Sorb; Sorbin homologous domain

  14. NM_001377201.1 → NP_001364130.1  sorbin and SH3 domain-containing protein 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:836 → 894
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:657 → 711
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:731 → 788
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:361 → 402
    Sorb; Sorbin homologous domain

  15. NM_001377202.1 → NP_001364131.1  sorbin and SH3 domain-containing protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:804 → 862
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:625 → 679
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:699 → 756
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:329 → 370
    Sorb; Sorbin homologous domain

  16. NM_001377203.1 → NP_001364132.1  sorbin and SH3 domain-containing protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:775 → 833
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:596 → 650
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:670 → 727
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:247 → 288
    Sorb; Sorbin homologous domain

  17. NM_001377204.1 → NP_001364133.1  sorbin and SH3 domain-containing protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    A0A3B3IT56
    Conserved Domains (4) summary
    smart00459
    Location:212 → 257
    Sorb; Sorbin homologous domain
    cd11916
    Location:774 → 832
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:595 → 649
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:669 → 726
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

  18. NM_001377205.1 → NP_001364134.1  sorbin and SH3 domain-containing protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:766 → 824
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:587 → 641
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:661 → 718
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:238 → 279
    Sorb; Sorbin homologous domain

  19. NM_001377206.1 → NP_001364135.1  sorbin and SH3 domain-containing protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:750 → 808
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:571 → 625
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:645 → 702
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:247 → 288
    Sorb; Sorbin homologous domain

  20. NM_001377207.1 → NP_001364136.1  sorbin and SH3 domain-containing protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:743 → 801
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:564 → 618
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:638 → 695
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:215 → 256
    Sorb; Sorbin homologous domain

  21. NM_001377208.1 → NP_001364137.1  sorbin and SH3 domain-containing protein 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:719 → 777
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:540 → 594
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:614 → 671
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:247 → 288
    Sorb; Sorbin homologous domain

  22. NM_001377209.1 → NP_001364138.1  sorbin and SH3 domain-containing protein 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:718 → 776
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:539 → 593
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:613 → 670
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:215 → 256
    Sorb; Sorbin homologous domain

  23. NM_001384447.1 → NP_001371376.1  sorbin and SH3 domain-containing protein 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Conserved Domains (4) summary
    cd11916
    Location:1547 → 1605
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1066 → 1120
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1140 → 1197
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215 → 256
    Sorb; Sorbin homologous domain

  24. NM_001384448.1 → NP_001371377.1  sorbin and SH3 domain-containing protein 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    A0A3B3IRW8
    Related
    ENSP00000497106.2, ENST00000649575.2
    Conserved Domains (5) summary
    cd11916
    Location:1560 → 1618
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1079 → 1133
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1153 → 1210
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    COG5665
    Location:41 → 327
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam02208
    Location:206 → 247
    Sorb; Sorbin homologous domain

  25. NM_001384449.1 → NP_001371378.1  sorbin and SH3 domain-containing protein 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Conserved Domains (4) summary
    cd11916
    Location:1525 → 1583
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1088 → 1142
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1162 → 1219
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215 → 256
    Sorb; Sorbin homologous domain

  26. NM_001384450.1 → NP_001371379.1  sorbin and SH3 domain-containing protein 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Conserved Domains (4) summary
    cd11916
    Location:1503 → 1561
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1066 → 1120
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1140 → 1197
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215 → 256
    Sorb; Sorbin homologous domain

  27. NM_001384451.1 → NP_001371380.1  sorbin and SH3 domain-containing protein 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Related
    ENSP00000475901.1, ENST00000607232.5
    Conserved Domains (4) summary
    cd11916
    Location:1245 → 1303
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1066 → 1120
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1140 → 1197
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215 → 256
    Sorb; Sorbin homologous domain

  28. NM_001384452.1 → NP_001371381.1  sorbin and SH3 domain-containing protein 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Conserved Domains (4) summary
    cd11916
    Location:1569 → 1627
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1088 → 1142
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1162 → 1219
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215 → 256
    Sorb; Sorbin homologous domain

  29. NM_001384453.1 → NP_001371382.1  sorbin and SH3 domain-containing protein 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Conserved Domains (4) summary
    cd11916
    Location:1267 → 1325
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1088 → 1142
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1162 → 1219
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215 → 256
    Sorb; Sorbin homologous domain

  30. NM_001384454.1 → NP_001371383.1  sorbin and SH3 domain-containing protein 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Conserved Domains (4) summary
    cd11916
    Location:1267 → 1325
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:1088 → 1142
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1162 → 1219
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215 → 256
    Sorb; Sorbin homologous domain

  31. NM_001384455.1 → NP_001371384.1  sorbin and SH3 domain-containing protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS76326.1
    UniProtKB/TrEMBL
    A0A3B3IT56
    Related
    ENSP00000360283.1, ENST00000371239.5
    Conserved Domains (4) summary
    smart00459
    Location:212 → 257
    Sorb; Sorbin homologous domain
    cd11916
    Location:752 → 810
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:573 → 627
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:647 → 704
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

  32. NM_001384456.1 → NP_001371385.1  sorbin and SH3 domain-containing protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS76326.1
    UniProtKB/TrEMBL
    A0A3B3IT56
    Conserved Domains (4) summary
    smart00459
    Location:212 → 257
    Sorb; Sorbin homologous domain
    cd11916
    Location:752 → 810
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:573 → 627
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:647 → 704
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

  33. NM_001384457.1 → NP_001371386.1  sorbin and SH3 domain-containing protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS76326.1
    UniProtKB/TrEMBL
    A0A3B3IT56
    Related
    ENSP00000497554.2, ENST00000649911.2
    Conserved Domains (4) summary
    smart00459
    Location:212 → 257
    Sorb; Sorbin homologous domain
    cd11916
    Location:752 → 810
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:573 → 627
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:647 → 704
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

  34. NM_001384458.1 → NP_001371387.1  sorbin and SH3 domain-containing protein 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    A0A3B3IT56
    Conserved Domains (4) summary
    cd11916
    Location:842 → 900
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:663 → 717
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:737 → 794
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:215 → 256
    Sorb; Sorbin homologous domain

  35. NM_001384459.1 → NP_001371388.1  sorbin and SH3 domain-containing protein 1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:839 → 897
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:660 → 714
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:734 → 791
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:247 → 288
    Sorb; Sorbin homologous domain

  36. NM_001384460.1 → NP_001371389.1  sorbin and SH3 domain-containing protein 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:818 → 876
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:639 → 693
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:713 → 770
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:247 → 288
    Sorb; Sorbin homologous domain

  37. NM_001384461.1 → NP_001371390.1  sorbin and SH3 domain-containing protein 1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:786 → 844
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:607 → 661
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:681 → 738
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:215 → 256
    Sorb; Sorbin homologous domain

  38. NM_001384462.1 → NP_001371391.1  sorbin and SH3 domain-containing protein 1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:777 → 835
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:598 → 652
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:672 → 729
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:206 → 247
    Sorb; Sorbin homologous domain

  39. NM_001384463.1 → NP_001371392.1  sorbin and SH3 domain-containing protein 1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:709 → 767
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:530 → 584
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:604 → 661
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:247 → 288
    Sorb; Sorbin homologous domain

  40. NM_001384464.1 → NP_001371393.1  sorbin and SH3 domain-containing protein 1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:705 → 763
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:526 → 580
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:600 → 657
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:215 → 256
    Sorb; Sorbin homologous domain

  41. NM_001384465.1 → NP_001371394.1  sorbin and SH3 domain-containing protein 1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    UniProtKB/TrEMBL
    B4DTX5
    Conserved Domains (4) summary
    cd11916
    Location:774 → 832
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:595 → 649
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:669 → 726
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:238 → 279
    Sorb; Sorbin homologous domain

  42. NM_001419685.1 → NP_001406614.1  sorbin and SH3 domain-containing protein 1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165

  43. NM_001419702.1 → NP_001406631.1  sorbin and SH3 domain-containing protein 1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165

  44. NM_001419703.1 → NP_001406632.1  sorbin and SH3 domain-containing protein 1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165

  45. NM_001419704.1 → NP_001406633.1  sorbin and SH3 domain-containing protein 1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165

  46. NM_006434.4 → NP_006425.3  sorbin and SH3 domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS31252.1
    UniProtKB/TrEMBL
    B4DTX5
    Related
    ENSP00000360285.1, ENST00000371241.5

  47. NM_015385.4 → NP_056200.2  sorbin and SH3 domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS7442.1
    UniProtKB/TrEMBL
    B4DTX5
    Related
    ENSP00000360295.2, ENST00000371249.6
    Conserved Domains (4) summary
    smart00459
    Location:335 → 380
    Sorb; Sorbin homologous domain
    cd11916
    Location:757 → 815
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:578 → 632
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:652 → 709
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin

  48. NM_024991.3 → NP_079267.2  sorbin and SH3 domain-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS31253.1
    UniProtKB/TrEMBL
    B4DTX5
    Related
    ENSP00000302556.6, ENST00000306402.10
    Conserved Domains (5) summary
    smart00459
    Location:244 → 289
    Sorb; Sorbin homologous domain
    cd11916
    Location:722 → 780
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:543 → 597
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:617 → 674
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam15449
    Location:83 → 241
    Retinal; Retinal protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    95311773..95561371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015539.2 → XP_016871028.1  sorbin and SH3 domain-containing protein 1 isoform X27

    UniProtKB/TrEMBL
    B4DTX5

  2. XM_017015540.2 → XP_016871029.1  sorbin and SH3 domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    B4DTX5

  3. XM_017015533.2 → XP_016871022.1  sorbin and SH3 domain-containing protein 1 isoform X23

    UniProtKB/TrEMBL
    B4DTX5

  4. XM_047424475.1 → XP_047280431.1  sorbin and SH3 domain-containing protein 1 isoform X20

  5. XM_047424471.1 → XP_047280427.1  sorbin and SH3 domain-containing protein 1 isoform X14

  6. XM_047424470.1 → XP_047280426.1  sorbin and SH3 domain-containing protein 1 isoform X13

  7. XM_047424479.1 → XP_047280435.1  sorbin and SH3 domain-containing protein 1 isoform X31

  8. XM_017015536.2 → XP_016871025.1  sorbin and SH3 domain-containing protein 1 isoform X24

    UniProtKB/TrEMBL
    B4DTX5

  9. XM_017015525.2 → XP_016871014.1  sorbin and SH3 domain-containing protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A3B3IT56

  10. XM_017015523.2 → XP_016871012.1  sorbin and SH3 domain-containing protein 1 isoform X15

    UniProtKB/TrEMBL
    B4DTX5

  11. XM_047424473.1 → XP_047280429.1  sorbin and SH3 domain-containing protein 1 isoform X18

  12. XM_047424478.1 → XP_047280434.1  sorbin and SH3 domain-containing protein 1 isoform X30

  13. XM_017015537.3 → XP_016871026.1  sorbin and SH3 domain-containing protein 1 isoform X25

    UniProtKB/TrEMBL
    B4DTX5

  14. XM_017015532.3 → XP_016871021.1  sorbin and SH3 domain-containing protein 1 isoform X22

    UniProtKB/TrEMBL
    B4DTX5

  15. XM_047424476.1 → XP_047280432.1  sorbin and SH3 domain-containing protein 1 isoform X26

  16. XM_047424474.1 → XP_047280430.1  sorbin and SH3 domain-containing protein 1 isoform X19

  17. XM_006717589.3 → XP_006717652.1  sorbin and SH3 domain-containing protein 1 isoform X9

    UniProtKB/Swiss-Prot
    Q9BX66
    Conserved Domains (4) summary
    cd11916
    Location:945 → 1003
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:766 → 820
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:840 → 897
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:361 → 399
    Sorb; Sorbin homologous domain

  18. XM_047424477.1 → XP_047280433.1  sorbin and SH3 domain-containing protein 1 isoform X29

  19. XM_017015530.3 → XP_016871019.1  sorbin and SH3 domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    B4DTX5

  20. XM_047424472.1 → XP_047280428.1  sorbin and SH3 domain-containing protein 1 isoform X17

  21. XM_047424469.1 → XP_047280425.1  sorbin and SH3 domain-containing protein 1 isoform X11

  22. XM_017015517.3 → XP_016871006.1  sorbin and SH3 domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    B4DTX5

  23. XM_017015515.3 → XP_016871004.1  sorbin and SH3 domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A3B3IT56

  24. XM_017015510.3 → XP_016870999.1  sorbin and SH3 domain-containing protein 1 isoform X8

  25. XM_017015505.3 → XP_016870994.1  sorbin and SH3 domain-containing protein 1 isoform X5

  26. XM_047424468.1 → XP_047280424.1  sorbin and SH3 domain-containing protein 1 isoform X7

  27. XM_017015503.3 → XP_016870992.1  sorbin and SH3 domain-containing protein 1 isoform X4

  28. XM_017015501.3 → XP_016870990.1  sorbin and SH3 domain-containing protein 1 isoform X2

  29. XM_011539150.3 → XP_011537452.1  sorbin and SH3 domain-containing protein 1 isoform X1

    Conserved Domains (4) summary
    cd11916
    Location:1446 → 1504
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:989 → 1043
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:1063 → 1120
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:609 → 650
    Sorb; Sorbin homologous domain

  30. XM_017015507.3 → XP_016870996.1  sorbin and SH3 domain-containing protein 1 isoform X6

  31. XM_017015502.3 → XP_016870991.1  sorbin and SH3 domain-containing protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    96190944..96440561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364574.1 → XP_054220549.1  sorbin and SH3 domain-containing protein 1 isoform X27

  2. XM_054364575.1 → XP_054220550.1  sorbin and SH3 domain-containing protein 1 isoform X28

  3. XM_054364570.1 → XP_054220545.1  sorbin and SH3 domain-containing protein 1 isoform X23

  4. XM_054364567.1 → XP_054220542.1  sorbin and SH3 domain-containing protein 1 isoform X20

  5. XM_054364561.1 → XP_054220536.1  sorbin and SH3 domain-containing protein 1 isoform X14

  6. XM_054364560.1 → XP_054220535.1  sorbin and SH3 domain-containing protein 1 isoform X13

  7. XM_054364578.1 → XP_054220553.1  sorbin and SH3 domain-containing protein 1 isoform X31

  8. XM_054364571.1 → XP_054220546.1  sorbin and SH3 domain-containing protein 1 isoform X24

  9. XM_054364563.1 → XP_054220538.1  sorbin and SH3 domain-containing protein 1 isoform X16

  10. XM_054364562.1 → XP_054220537.1  sorbin and SH3 domain-containing protein 1 isoform X15

  11. XM_054364565.1 → XP_054220540.1  sorbin and SH3 domain-containing protein 1 isoform X18

  12. XM_054364577.1 → XP_054220552.1  sorbin and SH3 domain-containing protein 1 isoform X30

  13. XM_054364572.1 → XP_054220547.1  sorbin and SH3 domain-containing protein 1 isoform X25

  14. XM_054364569.1 → XP_054220544.1  sorbin and SH3 domain-containing protein 1 isoform X22

  15. XM_054364573.1 → XP_054220548.1  sorbin and SH3 domain-containing protein 1 isoform X26

  16. XM_054364566.1 → XP_054220541.1  sorbin and SH3 domain-containing protein 1 isoform X19

  17. XM_054364556.1 → XP_054220531.1  sorbin and SH3 domain-containing protein 1 isoform X9

  18. XM_054364576.1 → XP_054220551.1  sorbin and SH3 domain-containing protein 1 isoform X29

  19. XM_054364568.1 → XP_054220543.1  sorbin and SH3 domain-containing protein 1 isoform X21

  20. XM_054364564.1 → XP_054220539.1  sorbin and SH3 domain-containing protein 1 isoform X17

  21. XM_054364558.1 → XP_054220533.1  sorbin and SH3 domain-containing protein 1 isoform X11

  22. XM_054364559.1 → XP_054220534.1  sorbin and SH3 domain-containing protein 1 isoform X12

  23. XM_054364557.1 → XP_054220532.1  sorbin and SH3 domain-containing protein 1 isoform X10

  24. XM_054364555.1 → XP_054220530.1  sorbin and SH3 domain-containing protein 1 isoform X8

  25. XM_054364552.1 → XP_054220527.1  sorbin and SH3 domain-containing protein 1 isoform X5

  26. XM_054364554.1 → XP_054220529.1  sorbin and SH3 domain-containing protein 1 isoform X7

  27. XM_054364551.1 → XP_054220526.1  sorbin and SH3 domain-containing protein 1 isoform X4

  28. XM_054364549.1 → XP_054220524.1  sorbin and SH3 domain-containing protein 1 isoform X2

  29. XM_054364548.1 → XP_054220523.1  sorbin and SH3 domain-containing protein 1 isoform X1

  30. XM_054364553.1 → XP_054220528.1  sorbin and SH3 domain-containing protein 1 isoform X6

  31. XM_054364550.1 → XP_054220525.1  sorbin and SH3 domain-containing protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BX66.3 GenPept UniProtKB/Swiss-Prot:Q9BX66

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