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DPYSL4 dihydropyrimidinase like 4 [ Homo sapiens (human) ]

Gene ID: 10570, updated on 7-Apr-2024

Summary

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Official Symbol
DPYSL4provided by HGNC
Official Full Name
dihydropyrimidinase like 4provided by HGNC
Primary source
HGNC:HGNC:3016
See related
Ensembl:ENSG00000151640 MIM:608407; AllianceGenome:HGNC:3016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRMP3; DRP-4; ULIP4
Summary
Enables filamin binding activity. Predicted to be involved in nervous system development. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.6), heart (RPKM 2.6) and 6 other tissues See more
Orthologs
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Genomic context

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Location:
10q26.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132186948..132205759)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133128313..133148570)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134000452..134019263)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133809534-133810520 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133820384-133820908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:133823019-133823543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133832958-133833629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133842692-133843192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133852590-133853427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133857569-133858086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133858087-133858604 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133878227-133878974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:133881249-133881749 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11218 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11222 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11225 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133920928-133921428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133933330-133934168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133934169-133935006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133951279-133951800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133955152-133955999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133956000-133956846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959409-133959910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959911-133960410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133960832-133961794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133977007-133977706 Neighboring gene JAKMIP3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134001171-134001672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4222 Neighboring gene serine/threonine kinase 32C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134056390-134057274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134067757-134068258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134068259-134068758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134078043-134078543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134096746-134097345 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134111356-134111519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122180-134122724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122725-134123267 Neighboring gene Sharpr-MPRA regulatory region 5064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:134144980-134145514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4224 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134152941-134153095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134166187-134167149 Neighboring gene leucine rich repeat containing 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134203032-134203711 Neighboring gene uncharacterized LOC124902526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134208622-134209145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134209146-134209668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2958

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Honnorat J, et al. Eur J Neurosci, 1999 Dec. PMID 10594648
  2. p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells. Nagano H, et al. Proc Natl Acad Sci U S A, 2018 Aug 14. PMID 30061407, Free PMC Article
  3. Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain. Weitzdoerfer R, et al. J Neural Transm Suppl, 2001. PMID 11771764
  4. Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis. Qiu L, et al. Biochem Genet, 2023 Feb. PMID 35877019
  5. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Kimura J, et al. Int J Cancer, 2011 Apr 1. PMID 20499313

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.
    Title: Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.
  2. DPYSL4 plays a key role in the tumor-suppressor function of p53 by regulating oxidative phosphorylation and the cellular energy supply via its association with mitochondrial supercomplexes, possibly linking to the pathophysiology of both cancer and obesity.
    Title: p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
  3. DPYSL4 is a novel apoptosis-inducible factor controlled by p53 in response to DNA damage
    Title: Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage.
  4. Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.
    Title: Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables filamin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
dihydropyrimidinase-related protein 4
Names
CRMP-3
ULIP-4
UNC33-like phosphoprotein 4
collapsin response mediator protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006426.3 → NP_006417.2  dihydropyrimidinase-related protein 4

    See identical proteins and their annotated locations for NP_006417.2

    Status: VALIDATED

    Source sequence(s)
    AL512622, BC029280, BC136329, BC142974
    Consensus CDS
    CCDS7665.1
    UniProtKB/Swiss-Prot
    B2RMQ1, D3DRG5, O00240, O14531, Q5T0Q7
    Related
    ENSP00000339850.3, ENST00000338492.9
    Conserved Domains (1) summary
    cd01314
    Location:17 → 466
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    132186948..132205759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    133128313..133148570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364500.1 → XP_054220475.1  dihydropyrimidinase-related protein 4 isoform X1

  2. XM_054364498.1 → XP_054220473.1  dihydropyrimidinase-related protein 4 isoform X1

  3. XM_054364499.1 → XP_054220474.1  dihydropyrimidinase-related protein 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14531.2 GenPept UniProtKB/Swiss-Prot:O14531

Gene LinkOut

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