Thtpa thiamine triphosphatase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thtpaprovided by MGI
Official Full Name: thiamine triphosphataseprovided by MGI
Primary source: MGI:MGI:2446078
See related: Ensembl:ENSMUSG00000045691 AllianceGenome:MGI:2446078
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a cytosolic enzyme that catalyzes the conversion of thiamine triphosphate to thiamine diphosphate. The encoded protein requires divalent cations for enzymatic activity. The gene product is believed to play a role in regulation of thiamine triphosphate intracellular concentration, and it may be a messenger in cell signaling in response to cellular stress. [provided by RefSeq, Mar 2010]
Expression: Ubiquitous expression in CNS E18 (RPKM 7.0), CNS E14 (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.07 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55332241..55336452)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55094784..55098995)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of the catalytic mechanism of mouse 25-kDa thiamine triphosphatase
Title: Structural basis for the catalytic mechanism of mammalian 25-kDa thiamine triphosphatase.
The highest amount of mRNA was found in testis, followed by lung and muscle, while the highest enzyme activities were found in liver and kidney
Title: Expression of 25 kDa thiamine triphosphatase in rodent tissues using quantitative PCR and characterization of its mRNA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AF068707 (e-PCR)
- UniSTS:160385

AW122966 (e-PCR)
- UniSTS:180657

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables thiamine triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in thiamine diphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in thiamine diphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine diphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in thiamine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thiamine-triphosphatase

Names: ThTPase

NP_694723.1

EC 3.6.1.28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.