HTATIP2 HIV-1 Tat interactive protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HTATIP2provided by HGNC
Official Full Name: HIV-1 Tat interactive protein 2provided by HGNC
Primary source: HGNC:HGNC:16637
See related: Ensembl:ENSG00000109854 MIM:605628; AllianceGenome:HGNC:16637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CC3; TIP30; SDR44U1
Summary: Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum (RPKM 33.4), small intestine (RPKM 30.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (20363714..20383782)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (20484405..20504464)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (20385260..20405328)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HTATIP2 Overexpression was Associated With a Good Prognosis in Gastric Cancer.
Title: HTATIP2 Overexpression was Associated With a Good Prognosis in Gastric Cancer.
HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia.
Title: HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia.
Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.
Title: Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.
The potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitis
Title: The potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitis.
TIP30 overcomes gefitinib resistance by regulating cytoplasmic and nuclear EGFR signaling in non-small-cell lung cancer.
Title: TIP30 overcomes gefitinib resistance by regulating cytoplasmic and nuclear EGFR signaling in non-small-cell lung cancer.
Clinical significance of changes in AFP, HTATIP2/TIP30, B7-H4 and inflammatory cytokines after transcatheter arterial chemoembolization.
Title: Clinical significance of changes in AFP, HTATIP2/TIP30, B7-H4 and inflammatory cytokines after transcatheter arterial chemoembolization.
Here, we identified the tumor suppressor protein TIP30 as novel inhibitor of cardiac hypertrophy and dysfunction. The results are relevant for human disease, since the authors found diminished cardiac TIP30 levels in samples from patients suffering from end-stage heart failure or hypertrophic cardiomyopathy.
Title: TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation.
Serum Golgi protein-73, alpha-fetoprotein-L3 and Tat-interacting protein-30 levels were significantly different in the hepatocellular carcinoma patients compared to controls, and those with chronic hepatitis and liver cirrhosis (p<0.01 each).
Title: Combined detection of AFP-L3, GP73 and TIP30 enhances diagnostic accuracy for HBV-related cirrhosis and hepatocellular carcinoma.
These results suggest that TIP30, as a tumor suppressor in the bladder cancer, might be served as a target in cancer therapies in the future.
Title: Overexpression of Tat-interacting protein 30 inhibits the proliferation, migration, invasion and promotes apoptosis in bladder cancer cells.
Binding of HIV1 Tat to TIP30 enhanced epithelial-to-mesenchymal transition and metastasis by regulating the nuclear translocation of Snail.
Title: Human immunodeficiency virus Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag interacts with HTATIP2 as demonstrated by proximity dependent biotinylation proteomics	PubMed
Tat	tat	HIV-1 Tat stimulates the phosphorylation of the RNA polymerase II C-terminal domain by TIP30	PubMed
	tat	TIP30 interacts with amino acids 1-48 of HIV-1 Tat, including the Tat activation domain, and enhances Tat activation of the HIV-1 LTR promoter	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G29234 (e-PCR)
- UniSTS:63559

SGC34227 (e-PCR)
- UniSTS:11714

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: oxidoreductase HTATIP2

Names: 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2; HIV-1 Tat interactive protein 2, 30kDa; Tat-interacting protein (30kD); short chain dehydrogenase/reductase family 44U, member 1

NP_001091990.1

EC 1.1.1.-

NP_001091991.1

EC 1.1.1.-

NP_001091992.1

EC 1.1.1.-

NP_001091993.1

EC 1.1.1.-

NP_006401.3

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098520.2 → NP_001091990.1 oxidoreductase HTATIP2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC025972, AK222969, BC015358, BP382529

Consensus CDS

CCDS44553.1

UniProtKB/Swiss-Prot

Q9BUP3

Related

ENSP00000392985.2, ENST00000419348.6

Conserved Domains (2) summary

cd05250
Location:53 → 265

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

COG0702
Location:55 → 205

YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
NM_001098521.2 → NP_001091991.1 oxidoreductase HTATIP2 isoform b

See identical proteins and their annotated locations for NP_001091991.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AC025972, AK222969, BC015358, DB450790

Consensus CDS

CCDS7852.1

UniProtKB/Swiss-Prot

A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3

UniProtKB/TrEMBL

E9PI87

Related

ENSP00000387876.2, ENST00000443524.6

Conserved Domains (1) summary

cd05250
Location:19 → 231

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
NM_001098522.2 → NP_001091992.1 oxidoreductase HTATIP2 isoform b

See identical proteins and their annotated locations for NP_001091992.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate 5' end and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AC025972, AI193677, AK222969, BC015358

Consensus CDS

CCDS7852.1

UniProtKB/Swiss-Prot

A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3

UniProtKB/TrEMBL

E9PI87

Related

ENSP00000394259.2, ENST00000451739.7

Conserved Domains (1) summary

cd05250
Location:19 → 231

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
NM_001098523.2 → NP_001091993.1 oxidoreductase HTATIP2 isoform c

See identical proteins and their annotated locations for NP_001091993.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and coding region, compared to variant 1. The resulting isoform (c, also known as TC3) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC025972, AF092095, AW963626

Consensus CDS

CCDS53613.1

UniProtKB/Swiss-Prot

Q9BUP3

Related

ENSP00000432107.1, ENST00000532081.1

Conserved Domains (1) summary

cl21454
Location:19 → 101

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_006410.5 → NP_006401.3 oxidoreductase HTATIP2 isoform b

See identical proteins and their annotated locations for NP_006401.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AK222969, BC015358, BF681178

Consensus CDS

CCDS7852.1

UniProtKB/Swiss-Prot

A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3

UniProtKB/TrEMBL

E9PI87

Related

ENSP00000397752.2, ENST00000421577.6

Conserved Domains (1) summary

cd05250
Location:19 → 231

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs