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Ankrd28 ankyrin repeat domain 28 [ Mus musculus (house mouse) ]

Gene ID: 105522, updated on 5-Mar-2024

Summary

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Official Symbol
Ankrd28provided by MGI
Official Full Name
ankyrin repeat domain 28provided by MGI
Primary source
MGI:MGI:2145661
See related
Ensembl:ENSMUSG00000014496 AllianceGenome:MGI:2145661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0379; E430019N21Rik
Summary
Predicted to be located in nucleus. Orthologous to human ANKRD28 (ankyrin repeat domain 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.4), CNS E14 (RPKM 4.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.4 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31418687..31552374, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31698768..31830567, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36317 Neighboring gene predicted gene, 57482 Neighboring gene STARR-seq mESC enhancer starr_36319 Neighboring gene STARR-positive B cell enhancer ABC_E11568 Neighboring gene 2-hydroxyacyl-CoA lyase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32483369-32483556 Neighboring gene biotinidase Neighboring gene predicted gene, 53840 Neighboring gene STARR-positive B cell enhancer ABC_E4102 Neighboring gene STARR-seq mESC enhancer starr_36323 Neighboring gene STARR-seq mESC enhancer starr_36326 Neighboring gene RIKEN cDNA D830044D21 gene Neighboring gene STARR-seq mESC enhancer starr_36327 Neighboring gene predicted gene, 36164 Neighboring gene predicted gene, 53172

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Chambers DM, et al. Genome Res, 1996 Aug. PMID 8858346
  2. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0379

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Names
PITK
PP6-ARS-A
ankyrin repeat domain-containing protein 28
phosphatase interactor targeting protein hnRNP K
serine/threonine-protein phosphatase 6 regulatory subunit ARS-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024604.3 → NP_001019775.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 1

    See identical proteins and their annotated locations for NP_001019775.1

    Status: VALIDATED

    Source sequence(s)
    AC109509, AC113598, AC120375
    Consensus CDS
    CCDS36858.1
    UniProtKB/Swiss-Prot
    Q505D1
    Related
    ENSMUSP00000014640.8, ENSMUST00000014640.9
    Conserved Domains (5) summary
    cd00204
    Location:134 → 259
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:42 → 71
    Ank; Ankyrin repeat
    pfam12796
    Location:177 → 269
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:756 → 808
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:140 → 170
    ANK; ANK repeat [structural motif]

  2. NM_001402762.1 → NP_001389691.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109509, AC120375
    UniProtKB/TrEMBL
    A0A2I3BQ07
    Related
    ENSMUSP00000153992.2, ENSMUST00000227863.2

  3. NM_001402763.1 → NP_001389692.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109509, AC113598, AC120375

  4. NM_001402764.1 → NP_001389693.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC109509, AC120375
    UniProtKB/TrEMBL
    A0A2I3BQJ1

  5. NM_001402765.1 → NP_001389694.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC109509, AC120375
    UniProtKB/TrEMBL
    A0A2I3BQJ1
    Related
    ENSMUSP00000154197.2, ENSMUST00000227089.2

  6. NM_001402766.1 → NP_001389695.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC109509, AC120375
    UniProtKB/TrEMBL
    A0A2I3BQJ1

RNA

  1. NR_175291.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC109509, AC113598, AC120375

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31418687..31552374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158365.1 → XP_036014258.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3

    Conserved Domains (5) summary
    PHA02874
    Location:182 → 491
    PHA02874; ankyrin repeat protein; Provisional
    PHA03095
    Location:17 → 343
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:246 → 278
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:555 → 585
    Ank; Ankyrin repeat
    pfam12796
    Location:455 → 548
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_011244886.1 → XP_011243188.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3

    Conserved Domains (5) summary
    PHA02874
    Location:182 → 491
    PHA02874; ankyrin repeat protein; Provisional
    PHA03095
    Location:17 → 343
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:246 → 278
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:555 → 585
    Ank; Ankyrin repeat
    pfam12796
    Location:455 → 548
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_036158366.1 → XP_036014259.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X4

    Conserved Domains (3) summary
    PHA03095
    Location:52 → 340
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:170 → 200
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:306 → 394
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_004938361.1 RNA Sequence

  2. XR_004938360.1 RNA Sequence

  3. XR_383131.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q505D1.1 GenPept UniProtKB/Swiss-Prot:Q505D1

Gene LinkOut

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