U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fam149b family with sequence similarity 149, member B [ Mus musculus (house mouse) ]

Gene ID: 105428, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Fam149bprovided by MGI
Official Full Name
family with sequence similarity 149, member Bprovided by MGI
Primary source
MGI:MGI:2145567
See related
Ensembl:ENSMUSG00000039599 AllianceGenome:MGI:2145567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam149b1; mKIAA0974
Summary
Predicted to be involved in cilium assembly and protein localization to cilium. Predicted to act upstream of or within cell projection organization. Predicted to be located in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human FAM149B1 (family with sequence similarity 149 member B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.2), CNS E14 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14 A3; 14 11.52 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20398221..20433559)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20348158..20383491)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1470 Neighboring gene nudix hydrolase 13 Neighboring gene ecdysoneless cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_36108 Neighboring gene STARR-positive B cell enhancer ABC_E7295 Neighboring gene predicted gene, 30054 Neighboring gene STARR-positive B cell enhancer ABC_E7296 Neighboring gene STARR-positive B cell enhancer ABC_E11564 Neighboring gene STARR-positive B cell enhancer ABC_E3105 Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 Neighboring gene mitochondrial ribosomal protein S16

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Gehman LT, et al. Genes Dev, 2012 Mar 1. PMID 22357600, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC32264

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
primary cilium assembly protein FAM149B1
Names
protein FAM149B1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024512.3 → NP_001019683.1  primary cilium assembly protein FAM149B1 isoform 1

    See identical proteins and their annotated locations for NP_001019683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS49409.1
    UniProtKB/Swiss-Prot
    A0JLS8, Q6NSV7, Q6PES0, Q6ZQ13, Q8CCW6, Q8R3J2
    Related
    ENSMUSP00000087985.6, ENSMUST00000090499.13
    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  2. NM_001177633.2 → NP_001171104.1  primary cilium assembly protein FAM149B1 isoform 3

    See identical proteins and their annotated locations for NP_001171104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (3) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS49408.1
    UniProtKB/Swiss-Prot
    Q6NSV7
    Related
    ENSMUSP00000153509.2, ENSMUST00000224721.2
    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  3. NM_001360364.2 → NP_001347293.1  primary cilium assembly protein FAM149B1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121801
    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  4. NM_001360365.2 → NP_001347294.1  primary cilium assembly protein FAM149B1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121801
    Conserved Domains (1) summary
    pfam12516
    Location:64 → 100
    DUF3719; Protein of unknown function (DUF3719)

  5. NM_001425986.1 → NP_001412915.1  primary cilium assembly protein FAM149B1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121801

  6. NM_001425987.1 → NP_001412916.1  primary cilium assembly protein FAM149B1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC121801

  7. NM_001425988.1 → NP_001412917.1  primary cilium assembly protein FAM149B1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC121801

  8. NM_001425989.1 → NP_001412918.1  primary cilium assembly protein FAM149B1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC121801

  9. NM_001425990.1 → NP_001412919.1  primary cilium assembly protein FAM149B1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC121801

  10. NM_001425991.1 → NP_001412920.1  primary cilium assembly protein FAM149B1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC121801

  11. NM_001425992.1 → NP_001412921.1  primary cilium assembly protein FAM149B1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC121801

  12. NM_172379.4 → NP_759011.2  primary cilium assembly protein FAM149B1 isoform 2

    See identical proteins and their annotated locations for NP_759011.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS49410.1
    UniProtKB/Swiss-Prot
    Q6NSV7
    Related
    ENSMUSP00000087989.5, ENSMUST00000090503.12
    Conserved Domains (1) summary
    pfam12516
    Location:117 → 169
    DUF3719; Protein of unknown function (DUF3719)

RNA

  1. NR_189649.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121801

  2. NR_189650.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121801

  3. NR_189651.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121801

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20398221..20433559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158339.1 → XP_036014232.1  primary cilium assembly protein FAM149B1 isoform X1

    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  2. XM_036158343.1 → XP_036014236.1  primary cilium assembly protein FAM149B1 isoform X6

    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  3. XM_036158342.1 → XP_036014235.1  primary cilium assembly protein FAM149B1 isoform X4

    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  4. XM_036158345.1 → XP_036014238.1  primary cilium assembly protein FAM149B1 isoform X8

    Conserved Domains (1) summary
    pfam12516
    Location:117 → 169
    DUF3719; Protein of unknown function (DUF3719)

  5. XM_036158344.1 → XP_036014237.1  primary cilium assembly protein FAM149B1 isoform X7

    Conserved Domains (1) summary
    pfam12516
    Location:64 → 100
    DUF3719; Protein of unknown function (DUF3719)

  6. XM_036158349.1 → XP_036014242.1  primary cilium assembly protein FAM149B1 isoform X12

  7. XM_036158353.1 → XP_036014246.1  primary cilium assembly protein FAM149B1 isoform X16

  8. XM_036158340.1 → XP_036014233.1  primary cilium assembly protein FAM149B1 isoform X2

    Conserved Domains (1) summary
    pfam12516
    Location:83 → 147
    DUF3719; Protein of unknown function (DUF3719)

  9. XM_036158346.1 → XP_036014239.1  primary cilium assembly protein FAM149B1 isoform X9

    Conserved Domains (1) summary
    pfam12516
    Location:9 → 73
    DUF3719; Protein of unknown function (DUF3719)

  10. XM_036158341.1 → XP_036014234.1  primary cilium assembly protein FAM149B1 isoform X3

    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  11. XM_036158351.1 → XP_036014244.1  primary cilium assembly protein FAM149B1 isoform X13

    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  12. XM_011244880.2 → XP_011243182.1  primary cilium assembly protein FAM149B1 isoform X17

    Conserved Domains (1) summary
    pfam12516
    Location:117 → 181
    DUF3719; Protein of unknown function (DUF3719)

  13. XM_006518336.1 → XP_006518399.1  primary cilium assembly protein FAM149B1 isoform X15

    See identical proteins and their annotated locations for XP_006518399.1

  14. XM_036158352.1 → XP_036014245.1  primary cilium assembly protein FAM149B1 isoform X14

RNA

  1. XR_004938355.1 RNA Sequence

  2. XR_004938356.1 RNA Sequence

  3. XR_001781076.2 RNA Sequence

  4. XR_004938354.1 RNA Sequence

  5. XR_004938353.1 RNA Sequence

  6. XR_001781072.2 RNA Sequence

    Related
    ENSMUST00000225834.2

  7. XR_004938357.1 RNA Sequence

  8. XR_004938358.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSV7.1 GenPept UniProtKB/Swiss-Prot:Q6NSV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous