Akr1c14 aldo-keto reductase family 1, member C14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1c14provided by MGI
Official Full Name: aldo-keto reductase family 1, member C14provided by MGI
Primary source: MGI:MGI:2145458
See related: Ensembl:ENSMUSG00000033715 AllianceGenome:MGI:2145458
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9030611N15Rik
Summary: Enables androsterone dehydrogenase activity. Predicted to be involved in glycoside metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in gut; liver; metanephros; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 28.6), liver E18 (RPKM 11.5) and 8 other tissues See more
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Genomic context

Location:: 13 A1; 13 2.26 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (4099015..4140569)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (4048991..4090560)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results identify a novel cooperation between MEF2 factors and NR2F2 in the expression of the Akr1c14 gene
Title: MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.
In conclusion, our data show that m3alpha-HSD mRNA is a reliable marker of lung maturity in normal pregnancy.
Title: Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.
This study evaluates 5alpha-reductase type I and 3alpha-hydroxysteroid dehydrogenase mRNA expression level in mouse brain by using in situ hybridization.
Title: Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Using RT-PCR and in situ hybridization, this study compares 5alpha-RI and 3alpha-HSD mRNA brain expression levels in group housed and in socially isolated male mice for 4 weeks.
Title: Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

Akr1c14 (e-PCR), detects polymorphism
- UniSTS:256599

AW557061 (e-PCR)
- UniSTS:185961

24.MHAa63b12.seq (e-PCR)
- UniSTS:123625

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase (B-specific) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	ISO Inferred from Sequence Orthology more info
enables carboxylic acid binding	ISO Inferred from Sequence Orthology more info
enables chlordecone reductase activity	ISO Inferred from Sequence Orthology more info
enables delta4-3-oxosteroid 5beta-reductase activity	ISO Inferred from Sequence Orthology more info
enables dihydrotestosterone 17-beta-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables geranylgeranyl reductase activity	ISO Inferred from Sequence Orthology more info
enables ketoreductase activity	ISO Inferred from Sequence Orthology more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables phenanthrene 9,10-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables steroid dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticosteroid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to jasmonic acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin stimulus	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in farnesol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3-alpha-hydroxysteroid dehydrogenase

Names: 3-alpha-hydroxysteroid dehydrogenase type 1

NP_598833.1

EC 1.1.1.213

EC 1.1.1.50

XP_030102973.1

EC 1.1.1.213

EC 1.1.1.50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134072.2 → NP_598833.1 3-alpha-hydroxysteroid dehydrogenase

See identical proteins and their annotated locations for NP_598833.1

Status: VALIDATED

Source sequence(s)

AC122840

Consensus CDS

CCDS26218.1

UniProtKB/TrEMBL

Q91WT7

Related

ENSMUSP00000045394.7, ENSMUST00000041768.7

Conserved Domains (1) summary

cd19108
Location:6 → 308

AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

4099015..4140569

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247113.2 → XP_030102973.1 3-alpha-hydroxysteroid dehydrogenase isoform X1

UniProtKB/TrEMBL

Q91WT7

Related

ENSMUSP00000112664.3, ENSMUST00000118717.10

Conserved Domains (1) summary

cd19108
Location:6 → 308

AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)