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LINC00973 long intergenic non-protein coding RNA 973 [ Homo sapiens (human) ]

Gene ID: 105374003, updated on 28-Oct-2023

Summary

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Official Symbol
LINC00973provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 973provided by HGNC
Primary source
HGNC:HGNC:48868
See related
AllianceGenome:HGNC:48868
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
3q12.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (98914566..98998841)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (101622897..101707180)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:98619438-98620154 and GRCh37_chr3:98620155-98620870 Neighboring gene uncharacterized LOC105374002 Neighboring gene RNA, U6 small nuclear 1263, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3286 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:98647410-98647601 Neighboring gene U7 small nuclear RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:98783203-98783703 Neighboring gene actin gamma 1 pseudogene 13 Neighboring gene uncharacterized LOC124909399 Neighboring gene uncharacterized LOC107986104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation. Karpov DS, et al. Int J Mol Sci, 2020 Nov 6. PMID 33171937, Free PMC Article
  2. Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs. Zinovieva OL, et al. Biochimie, 2018 Aug. PMID 29870803
  3. Risk score based on ten lncRNA-mRNA expression predicts the survival of stage II-III colorectal carcinoma. Diao R, et al. PLoS One, 2017. PMID 28796819, Free PMC Article
  4. LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma. Liu Y, et al. Cancer Sci, 2020 Oct. PMID 32780490, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation.
    Title: LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation.
  2. LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma.
    Title: LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

Genotypes

General gene information

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Other Names

  • CTD-2021J15.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_186665.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026303, AC091212

  2. NR_186666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212, AC106704

  3. NR_186667.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212, AC106704

  4. NR_186668.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212, AC106704

  5. NR_186669.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212, AC106704

  6. NR_186670.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212, AC106704

  7. NR_186671.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212

  8. NR_186672.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212

  9. NR_186673.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212

  10. NR_186674.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212

  11. NR_186675.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212

  12. NR_186676.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091212

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    98914566..98998841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    101622897..101707180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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