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LINC01638 long intergenic non-protein coding RNA 1638 [ Homo sapiens (human) ]

Gene ID: 105372978, updated on 10-Oct-2023

Summary

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Official Symbol
LINC01638provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1638provided by HGNC
Primary source
HGNC:HGNC:52425
See related
Ensembl:ENSG00000233521 AllianceGenome:HGNC:52425
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
lncRNA4114
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
22q12.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (27221350..27224679, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (27682239..27685568, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (27617311..27620640, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985534 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:27566132-27567331 Neighboring gene uncharacterized LOC105372977 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:27622369-27623568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27654930-27655430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27655431-27655931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27692319-27692881 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27706583-27707357 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27707358-27708131 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:27710082-27710283 Neighboring gene long intergenic non-protein coding RNA 2554 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63191 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63195 Neighboring gene uncharacterized LOC105372979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. N6-methyladenosine promotes osteogenic differentiation of PDLSCs from periodontitis patients. Zhang X, et al. Oral Dis, 2022 Dec 14. PMID 36516331
  2. Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer. Liu P, et al. Curr Cancer Drug Targets, 2019. PMID 29992881, Free PMC Article
  3. Downregulation of LINC01638 lncRNA inhibits migration and invasion of pancreatic ductal adenocarcinoma cells by reducing TGF‑β signaling. Lu H, et al. Mol Med Rep, 2019 Nov. PMID 31702018, Free PMC Article
  4. SP1-regulated LINC01638 promotes proliferation and inhibits apoptosis in non-small cell lung cancer. Guo L, et al. Eur Rev Med Pharmacol Sci, 2019 Oct. PMID 31696478
  5. LINC01638 lncRNA promotes the proliferation, migration and invasion of prostate carcinoma cells by interacting with Notch1. Wu Z, et al. Cancer Biomark, 2019. PMID 31104008

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ETS like-1 protein ELK1-induced lncRNA LINC01638 accelerates the progression of papillary thyroid cancer by regulating Axin2 through Wnt/beta-catenin signaling pathway.
    Title: ETS like-1 protein ELK1-induced lncRNA LINC01638 accelerates the progression of papillary thyroid cancer by regulating Axin2 through Wnt/β-catenin signaling pathway.
  2. Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer progression by modulating miR-523-5p/BATF3 axis.
    Title: Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer progression by modulating miR-523-5p/BATF3 axis.
  3. SP1-regulated LINC01638 promotes proliferation and inhibits apoptosis in non-small cell lung cancer.
    Title: SP1-regulated LINC01638 promotes proliferation and inhibits apoptosis in non-small cell lung cancer.
  4. It is concluded that LINC01638 lncRNA may be involved in the migration and invasion of pancreatic ductal adenocarcinoma cells via regulation of TGFbeta1.
    Title: Downregulation of LINC01638 lncRNA inhibits migration and invasion of pancreatic ductal adenocarcinoma cells by reducing TGF‑β signaling.
  5. Linc01638 was over-expressed in HER2-positive breast cancer cells and tumor tissues. Linc01638 plays a crucial role in HER2-positive breast cancer, especially in tumor growth and metastasis.
    Title: Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_171021.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL021153, AL034386
    Related
    ENST00000444114.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    27221350..27224679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    27682239..27685568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001350812.2: Suppressed sequence

    Description
    NM_001350812.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version

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