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MIR194-2HG MIR194-2 host gene [ Homo sapiens (human) ]

Gene ID: 105369343, updated on 10-Oct-2023

Summary

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Official Symbol
MIR194-2HGprovided by HGNC
Official Full Name
MIR194-2 host geneprovided by HGNC
Primary source
HGNC:HGNC:51946
See related
Ensembl:ENSG00000229719 AllianceGenome:HGNC:51946
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in small intestine (RPKM 9.0), duodenum (RPKM 8.0) and 4 other tissues See more
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Genomic context

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Location:
11q13.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64888458..64893449, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64881697..64886688, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64655930..64660921, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene EH domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4932 Neighboring gene microRNA 10392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64650863-64651364 Neighboring gene ribosomal protein S16 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64654864-64655434 Neighboring gene microRNA 194-2 Neighboring gene microRNA 192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4933 Neighboring gene autophagy related 2A Neighboring gene microRNA 6750 Neighboring gene microRNA 6749

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. Hino K, et al. RNA, 2008 Jul. PMID 18492795, Free PMC Article
  2. Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients. Shi L, et al. Ann Diagn Pathol, 2020 Jun. PMID 32172218
  3. miR-194 as predictive biomarker of responsiveness to neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma. D'Angelo E, et al. J Clin Pathol, 2018 Apr. PMID 28870889
  4. miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer. Wu J, et al. Pathol Res Pract, 2020 Jul. PMID 32534701
  5. miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein. Zhu X, et al. Oncotarget, 2016 Mar 15. PMID 26909612, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients.
    Title: Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients.
  2. miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer.
    Title: miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer.
  3. The present study...identified miR-194 as predictive biomarker of response to preoperative chemoradiotherapy for locally advanced rectal cancer
    Title: miR-194 as predictive biomarker of responsiveness to neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma.
  4. These findings suggested that miR-194 inhibits proliferation and metastasis and reverses cisplatin-resistance of non-small cell lung cancer cells
    Title: miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein.
  5. miR-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4
    Title: MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Other Names

  • pri-microRNA-194-2, -192

Clone Names

  • FLJ26898, AP001187.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_133638.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK092802, AP001187

  2. NR_133639.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate splice site in the 5' region and differs in the 3' exon structure, resulting in a shorter transcript than variant 1.
    Source sequence(s)
    AP001187
    Related
    ENST00000710930.1

  3. NR_133640.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate splice site in the 5' region and differs in the 3' exon structure, resulting in a shorter transcript than variant 1.
    Source sequence(s)
    AP001187
    Related
    ENST00000710929.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64888458..64893449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64881697..64886688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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