U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Golm1 golgi membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 105348, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Golm1provided by MGI
Official Full Name
golgi membrane protein 1provided by MGI
Primary source
MGI:MGI:1917329
See related
Ensembl:ENSMUSG00000021556 AllianceGenome:MGI:1917329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GP73; Golph2; PSEC0257; 2310001L02Rik; D030064E01Rik
Summary
Acts upstream of or within nucleus organization and regulation of lipid metabolic process. Located in Golgi apparatus. Is expressed in rectum. Orthologous to human GOLM1 (golgi membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 65.4), large intestine adult (RPKM 43.3) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13 B2; 13 31.87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59782810..59823598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59634996..59675784, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230056J06 gene Neighboring gene STARR-seq mESC enhancer starr_34713 Neighboring gene N(alpha)-acetyltransferase 35, NatC auxiliary subunit Neighboring gene STARR-seq mESC enhancer starr_34715 Neighboring gene STARR-seq mESC enhancer starr_34717 Neighboring gene STARR-seq mESC enhancer starr_34719 Neighboring gene RIKEN cDNA 4921517D22 gene Neighboring gene spermatogenesis associated 31 subfamily D, member 1A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity. Peng Y, et al. Nat Commun, 2021 Dec 1. PMID 34853313, Free PMC Article
  2. GOLM1 suppresses autophagy-mediated anti-tumor immunity in hepatocellular carcinoma. Sui T, et al. Signal Transduct Target Ther, 2021 Sep 17. PMID 34531366, Free PMC Article
  3. Deletion of Golgi protein 73 delayed hepatocyte proliferation of mouse in the early stages of liver regeneration. Wang J, et al. J Gastroenterol Hepatol, 2021 May. PMID 33119928
  4. GOLM1 Stimulation of Glutamine Metabolism Promotes Osteoporosis via Inhibiting Osteogenic Differentiation of BMSCs. Shen G, et al. Cell Physiol Biochem, 2018. PMID 30396165
  5. GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia. Wan L, et al. Nat Metab, 2022 Jan. PMID 34992299

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
    Title: PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
  2. Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
    Title: Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
  3. GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1.
    Title: GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1.
  4. Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy.
    Title: Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy.
  5. GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
    Title: GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
  6. GOLM1 suppresses autophagy-mediated anti-tumor immunity in hepatocellular carcinoma.
    Title: GOLM1 suppresses autophagy-mediated anti-tumor immunity in hepatocellular carcinoma.
  7. GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis.
    Title: GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis.
  8. GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia.
    Title: GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia.
  9. GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity.
    Title: GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity.
  10. Deletion of Golgi protein 73 delayed hepatocyte proliferation of mouse in the early stages of liver regeneration.
    Title: Deletion of Golgi protein 73 delayed hepatocyte proliferation of mouse in the early stages of liver regeneration.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1) 
  • Endonuclease-mediated (4) 

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC107447

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Golgi membrane protein 1
Names
golgi membrane protein GP73
golgi phosphoprotein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035122.2 → NP_001030294.1  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_001030294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK051066, AK167646, CK391733, CN529028, DV645181
    Consensus CDS
    CCDS26576.1
    UniProtKB/Swiss-Prot
    G3X8U4, Q91XA2
    UniProtKB/TrEMBL
    Q3UZG0
    Related
    ENSMUSP00000022039.6, ENSMUST00000022039.7
    Conserved Domains (1) summary
    cl23887
    Location:106 → 211
    DUF4349; Domain of unknown function (DUF4349)

  2. NM_027307.4 → NP_081583.3  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_081583.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AK009072, AK051066, BU152451, CD552063, CD560663, CK391733
    Consensus CDS
    CCDS26576.1
    UniProtKB/Swiss-Prot
    G3X8U4, Q91XA2
    UniProtKB/TrEMBL
    Q3UZG0
    Related
    ENSMUSP00000093410.3, ENSMUST00000095739.10
    Conserved Domains (1) summary
    cl23887
    Location:106 → 211
    DUF4349; Domain of unknown function (DUF4349)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    59782810..59823598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XA2.2 GenPept UniProtKB/Swiss-Prot:Q91XA2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous