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HYOU1 hypoxia up-regulated 1 [ Homo sapiens (human) ]

Gene ID: 10525, updated on 3-Apr-2024

Summary

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Official Symbol
HYOU1provided by HGNC
Official Full Name
hypoxia up-regulated 1provided by HGNC
Primary source
HGNC:HGNC:16931
See related
Ensembl:ENSG00000149428 MIM:601746; AllianceGenome:HGNC:16931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD59; Grp170; HSP12A; ORP150; GRP-170; ORP-150
Summary
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Broad expression in thyroid (RPKM 93.3), testis (RPKM 55.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q23.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (119044188..119057205, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (119064550..119077556, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118914899..118927916, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene centrosomal AT-AC splicing factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5616 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118889349-118890047 Neighboring gene ribosomal protein S25 Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene solute carrier family 37 member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3962 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:118906707-118906861 Neighboring gene HYOU1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5617 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118927013-118927514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118927515-118928014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5618 Neighboring gene uncharacterized LOC124902769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5620 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer. Wang W, et al. Mol Biol Rep, 2023 Jan. PMID 36348197
  2. HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA. Wang JM, et al. J Cell Mol Med, 2021 May. PMID 33792181, Free PMC Article
  3. Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids. Lee M, et al. Mol Cells, 2021 Jan 31. PMID 33455947, Free PMC Article
  4. HYOU1 promotes cell growth and metastasis via activating PI3K/AKT signaling in epithelial ovarian cancer and predicts poor prognosis. Li X, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 31173282
  5. The 150-kDa oxygen-regulated protein (ORP150) regulates proteinuria in diabetic nephropathy via mediating VEGF. Wang DQ, et al. Exp Mol Pathol, 2019 Oct. PMID 31028725

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
    Title: HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
  2. The Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects.
    Title: The Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects.
  3. Long non-coding RNA KCNQ1OT1 facilitates the progression of cervical cancer and tumor growth through modulating miR-296-5p/HYOU1 axis.
    Title: Long non-coding RNA KCNQ1OT1 facilitates the progression of cervical cancer and tumor growth through modulating miR-296-5p/HYOU1 axis.
  4. HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA.
    Title: HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA.
  5. Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids.
    Title: Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids.
  6. Long non-coding antisense RNA HYOU1-AS is essential to human breast cancer development through competitive binding hnRNPA1 to promote HYOU1 expression.
    Title: Long non-coding antisense RNA HYOU1-AS is essential to human breast cancer development through competitive binding hnRNPA1 to promote HYOU1 expression.
  7. Study found that the expression levels of HYOU1 were significantly upregulated in both EOC tissues and cell lines, and associated with advanced FIGO stage, LN metastasis, and shorter overall survival. In addition, high HYOU1 expression as an unfavorable factor for overall survival. Its inhibition of HYOU1 suppressed tumor proliferation and colony formation, as well as the migratory and invasive capacity.
    Title: HYOU1 promotes cell growth and metastasis via activating PI3K/AKT signaling in epithelial ovarian cancer and predicts poor prognosis.
  8. Serum level of ORP150 was significantly up-regulated in the diabetic nephropathy patients.ORP150 levels were positively correlated with proteinuria burden via mediating VEGF in the diabetic nephropathy.
    Title: The 150-kDa oxygen-regulated protein (ORP150) regulates proteinuria in diabetic nephropathy via mediating VEGF.
  9. we demonstrate that in the ER,Akita forms detergent-insoluble protein aggregates that entrap WT proinsulin. Strikingly, we find that two distinct ER quality-control pathways are deployed to limit the levels of these aggregates. First, Grp170 acts to prevent formation of detergent-insoluble Akita aggregates, which otherwise recruit and capture WT proinsulin.
    Title: Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.
  10. ORP150 and CHIP demonstrate antagonism under normal and stress conditions wherein they inversely regulate each other thus affecting BACE1 level.
    Title: ORP150-CHIP chaperone antagonism control BACE1-mediated amyloid processing.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Granulocytopenia with immunoglobulin abnormality
MedGen: C1856263 OMIM: 233600 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with hypoxia up-regulated 1 (HYOU1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with HYOU1; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of hypoxia up-regulated 1 (HYOU1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ94899, FLJ97572, DKFZp686N08236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endocytic vesicle lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in smooth endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
hypoxia up-regulated protein 1
Names
150 kDa oxygen-regulated protein
170 kDa glucose-regulated protein
epididymis secretory sperm binding protein
oxygen regulated protein (150kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130991.3 → NP_001124463.1  hypoxia up-regulated protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001124463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AA580314, AK127324, AK299648, AK301514, BC072436, HY089857, U65785
    Consensus CDS
    CCDS8408.1
    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6, B3KXH0
    Related
    ENSP00000480248.2, ENST00000614711.5
    Conserved Domains (2) summary
    cl00478
    Location:593 → 694
    LGT; Prolipoprotein diacylglyceryl transferase
    cl17037
    Location:36 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_001411041.1 → NP_001397970.1  hypoxia up-regulated protein 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003392, KF510357, KF511132
    Consensus CDS
    CCDS91604.1
    UniProtKB/TrEMBL
    A0A494C039
    Related
    ENSP00000511601.1, ENST00000694935.1

  3. NM_006389.5 → NP_006380.1  hypoxia up-regulated protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA580314, AK127324, AK301514, BC072436, DC364982, HY089857, U65785
    Consensus CDS
    CCDS8408.1
    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6, B3KXH0
    Related
    ENSP00000480150.1, ENST00000617285.5
    Conserved Domains (2) summary
    cl00478
    Location:593 → 694
    LGT; Prolipoprotein diacylglyceryl transferase
    cl17037
    Location:36 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    119044188..119057205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271392.5 → XP_005271449.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005271449.1

    UniProtKB/TrEMBL
    A0A494C039, B3KXH0
    Related
    ENSP00000498353.1, ENST00000652093.1
    Conserved Domains (2) summary
    PRK13108
    Location:593 → 694
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cl17037
    Location:36 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_017017097.2 → XP_016872586.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6, B3KXH0
    Related
    ENSP00000462951.2, ENST00000534233.6
    Conserved Domains (2) summary
    cl00478
    Location:593 → 694
    LGT; Prolipoprotein diacylglyceryl transferase
    cl17037
    Location:36 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_005271393.4 → XP_005271450.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005271450.1

    UniProtKB/TrEMBL
    A0A494C039, B3KXH0
    Related
    ENSP00000511598.1, ENST00000694932.1
    Conserved Domains (2) summary
    PRK13108
    Location:593 → 694
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cl17037
    Location:36 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_017017096.2 → XP_016872585.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6, B3KXH0
    Related
    ENSP00000431874.2, ENST00000530473.6
    Conserved Domains (2) summary
    cl00478
    Location:593 → 694
    LGT; Prolipoprotein diacylglyceryl transferase
    cl17037
    Location:36 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. XM_005271394.4 → XP_005271451.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005271451.1

    UniProtKB/TrEMBL
    A0A494C039, B3KXH0
    Conserved Domains (2) summary
    PRK13108
    Location:593 → 694
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cl17037
    Location:36 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  6. XM_047426254.1 → XP_047282210.1  hypoxia up-regulated protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SHG4
    Related
    ENSP00000511599.1, ENST00000694933.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646203.1 Reference GRCh38.p14 PATCHES

    Range
    65787..78804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331611.1 → XP_054187586.1  hypoxia up-regulated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A494C039

  2. XM_054331614.1 → XP_054187589.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6

  3. XM_054331615.1 → XP_054187590.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6

  4. XM_054331612.1 → XP_054187587.1  hypoxia up-regulated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A494C039

  5. XM_054331613.1 → XP_054187588.1  hypoxia up-regulated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A494C039

  6. XM_054331616.1 → XP_054187591.1  hypoxia up-regulated protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SHG4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    119064550..119077556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367470.1 → XP_054223445.1  hypoxia up-regulated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A494C039

  2. XM_054367473.1 → XP_054223448.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6

  3. XM_054367474.1 → XP_054223449.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8C1Z0, B7Z909, Q2I204, Q53H25, Q9Y4L1
    UniProtKB/TrEMBL
    A0A384P5T6

  4. XM_054367471.1 → XP_054223446.1  hypoxia up-regulated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A494C039

  5. XM_054367472.1 → XP_054223447.1  hypoxia up-regulated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A494C039

  6. XM_054367475.1 → XP_054223450.1  hypoxia up-regulated protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SHG4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4L1.1 GenPept UniProtKB/Swiss-Prot:Q9Y4L1

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