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Rnf44 ring finger protein 44 [ Mus musculus (house mouse) ]

Gene ID: 105239, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf44provided by MGI
Official Full Name
ring finger protein 44provided by MGI
Primary source
MGI:MGI:2145310
See related
Ensembl:ENSMUSG00000034928 AllianceGenome:MGI:2145310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1100
Summary
Predicted to enable metal ion binding activity. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; male reproductive system; and urinary system. Orthologous to human RNF44 (ring finger protein 44). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 91.4), thymus adult (RPKM 80.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 28.94 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54827212..54841889, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54679399..54694076, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34588 Neighboring gene STARR-seq mESC enhancer starr_34589 Neighboring gene clathrin light chain B Neighboring gene STARR-seq mESC enhancer starr_34590 Neighboring gene STARR-seq mESC enhancer starr_34591 Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54788483-54788694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54789238-54789421 Neighboring gene STARR-positive B cell enhancer ABC_E2408 Neighboring gene STARR-positive B cell enhancer ABC_E3083 Neighboring gene cadherin-related family member 2 Neighboring gene G protein-regulated inducer of neurite outgrowth 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING finger protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146025.1 → NP_001139497.1  RING finger protein 44 isoform 1

    See identical proteins and their annotated locations for NP_001139497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK161651, BC017630, CF426263, CJ106658
    Consensus CDS
    CCDS49268.1
    UniProtKB/TrEMBL
    E9PUC0
    Related
    ENSMUSP00000118474.2, ENSMUST00000125871.8
    Conserved Domains (1) summary
    cd16680
    Location:371 → 432
    RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

  2. NM_001146026.1 → NP_001139498.1  RING finger protein 44 isoform 2

    See identical proteins and their annotated locations for NP_001139498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK147349, BC017630, CF426263, CJ106658
    UniProtKB/Swiss-Prot
    Q3TAC8, Q3TVH9, Q3UHJ8, Q6ZPX8, Q8VD22
    Conserved Domains (1) summary
    pfam13639
    Location:355 → 396
    zf-RING_2; Ring finger domain

  3. NM_001146027.1 → NP_001139499.1  RING finger protein 44 isoform 3

    See identical proteins and their annotated locations for NP_001139499.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a segment of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK147349, BB841172, BC017630, CF426263, CF728349
    Consensus CDS
    CCDS49267.1
    UniProtKB/Swiss-Prot
    Q3UHJ8
    Related
    ENSMUSP00000123198.2, ENSMUST00000150806.8
    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  4. NM_134064.2 → NP_598825.2  RING finger protein 44 isoform 4

    See identical proteins and their annotated locations for NP_598825.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a segment of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the mid coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK160115, BC017630, CF426263, CJ106658
    Consensus CDS
    CCDS49266.1
    UniProtKB/Swiss-Prot
    Q3UHJ8
    Related
    ENSMUSP00000136732.2, ENSMUST00000177950.8
    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

RNA

  1. NR_027395.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an alternate 5' exon and an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that would inhibit the translation of the expected primary ORF, as found in variant 1. Translation of the upstream ORF would render this transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    BC017630, BY346776, CD349765, CF426263, CJ147978

  2. NR_027396.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate 5' exon and alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that would inhibit the translation of the expected primary ORF, as found in variant 1. Translation of the upstream ORF would render this transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    BC017630, BY346776, CD349765, CF426263

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54827212..54841889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247093.1 → XP_030102953.1  RING finger protein 44 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  2. XM_030247090.1 → XP_030102950.1  RING finger protein 44 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  3. XM_030247097.2 → XP_030102957.1  RING finger protein 44 isoform X4

    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  4. XM_030247088.2 → XP_030102948.1  RING finger protein 44 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:376 → 420
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  5. XM_006517019.5 → XP_006517082.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_006517082.1

    UniProtKB/TrEMBL
    E9PUC0
    Conserved Domains (1) summary
    cd16680
    Location:371 → 432
    RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

  6. XM_006517020.3 → XP_006517083.1  RING finger protein 44 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:376 → 420
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  7. XM_011244446.2 → XP_011242748.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_011242748.1

    UniProtKB/TrEMBL
    E9PUC0
    Conserved Domains (1) summary
    cd16680
    Location:371 → 432
    RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

  8. XM_017315336.1 → XP_017170825.1  RING finger protein 44 isoform X3

    UniProtKB/Swiss-Prot
    Q3UHJ8
    Related
    ENSMUSP00000114259.2, ENSMUST00000134862.8
    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  9. XM_030247099.1 → XP_030102959.1  RING finger protein 44 isoform X4

    Related
    ENSMUSP00000043974.10, ENSMUST00000037422.16
    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  10. XM_030247089.1 → XP_030102949.1  RING finger protein 44 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  11. XM_030247096.2 → XP_030102956.1  RING finger protein 44 isoform X4

    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  12. XM_011244450.1 → XP_011242752.1  RING finger protein 44 isoform X3

    See identical proteins and their annotated locations for XP_011242752.1

    UniProtKB/Swiss-Prot
    Q3UHJ8
    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  13. XM_006517018.5 → XP_006517081.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_006517081.1

    UniProtKB/TrEMBL
    E9PUC0
    Conserved Domains (1) summary
    cd16680
    Location:371 → 432
    RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

  14. XM_030247087.1 → XP_030102947.1  RING finger protein 44 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:376 → 420
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  15. XM_011244447.1 → XP_011242749.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_011242749.1

    UniProtKB/TrEMBL
    E9PUC0
    Conserved Domains (1) summary
    cd16680
    Location:371 → 432
    RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

  16. XM_030247095.2 → XP_030102955.1  RING finger protein 44 isoform X4

    Related
    ENSMUSP00000116850.2, ENSMUST00000128257.8
    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  17. XM_030247100.1 → XP_030102960.1  RING finger protein 44 isoform X4

    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  18. XM_030247092.1 → XP_030102952.1  RING finger protein 44 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  19. XM_011244449.2 → XP_011242751.1  RING finger protein 44 isoform X3

    See identical proteins and their annotated locations for XP_011242751.1

    UniProtKB/Swiss-Prot
    Q3UHJ8
    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  20. XM_030247085.2 → XP_030102945.1  RING finger protein 44 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:376 → 420
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  21. XM_030247091.1 → XP_030102951.1  RING finger protein 44 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  22. XM_011244451.1 → XP_011242753.1  RING finger protein 44 isoform X4

    See identical proteins and their annotated locations for XP_011242753.1

    UniProtKB/Swiss-Prot
    Q3UHJ8
    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  23. XM_036157809.1 → XP_036013702.1  RING finger protein 44 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:296 → 340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  24. XM_030247098.1 → XP_030102958.1  RING finger protein 44 isoform X4

    Conserved Domains (1) summary
    cd16472
    Location:295 → 339
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHJ8.1 GenPept UniProtKB/Swiss-Prot:Q3UHJ8

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