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Arrdc3 arrestin domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 105171, updated on 21-Apr-2024

Summary

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Official Symbol
Arrdc3provided by MGI
Official Full Name
arrestin domain containing 3provided by MGI
Primary source
MGI:MGI:2145242
See related
Ensembl:ENSMUSG00000074794 AllianceGenome:MGI:2145242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1376
Summary
Predicted to enable beta-3 adrenergic receptor binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including fat pad development; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and negative regulation of locomotion involved in locomotory behavior. Predicted to be located in lysosome and membrane. Predicted to be active in endosome and plasma membrane. Is expressed in central nervous system; liver; lung; olfactory epithelium; and retina nuclear layer. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 18.7), limb E14.5 (RPKM 10.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C2; 13 41.95 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81031508..81044161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (80883384..80896042)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35103 Neighboring gene STARR-seq mESC enhancer starr_35104 Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35105 Neighboring gene STARR-seq mESC enhancer starr_35106 Neighboring gene STARR-seq mESC enhancer starr_35107 Neighboring gene STARR-seq mESC enhancer starr_35108 Neighboring gene STARR-seq mESC enhancer starr_35109 Neighboring gene STARR-seq mESC enhancer starr_35110 Neighboring gene STARR-positive B cell enhancer ABC_E7255 Neighboring gene STARR-positive B cell enhancer ABC_E7256 Neighboring gene STARR-positive B cell enhancer ABC_E4081 Neighboring gene STARR-seq mESC enhancer starr_35112 Neighboring gene STARR-positive B cell enhancer ABC_E3087 Neighboring gene RIKEN cDNA 5430425K12 gene Neighboring gene STARR-seq mESC enhancer starr_35115 Neighboring gene predicted gene 4211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli. Gordon BS, et al. Physiol Genomics, 2019 Jun 1. PMID 31002587
  2. Comprehensive multi-omics analysis uncovers a group of TGF-β-regulated genes among lncRNA EPR direct transcriptional targets. Zapparoli E, et al. Nucleic Acids Res, 2020 Sep 18. PMID 32756918, Free PMC Article
  3. Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1. Liu YG, et al. JCI Insight, 2020 Aug 6. PMID 32634127, Free PMC Article
  4. Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver. Batista TM, et al. Proc Natl Acad Sci U S A, 2020 Mar 24. PMID 32156724, Free PMC Article
  5. The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. Patwari P, et al. J Biol Chem, 2006 Aug 4. PMID 16766796, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses.
    Title: Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses.
  2. Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1.
    Title: Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1.
  3. Comprehensive multi-omics analysis uncovers a group of TGF-beta-regulated genes among lncRNA EPR direct transcriptional targets.
    Title: Comprehensive multi-omics analysis uncovers a group of TGF-β-regulated genes among lncRNA EPR direct transcriptional targets.
  4. Arrdc2 and Arrdc3 are a novel set of genes that may be implicated in the regulation of skeletal muscle mass.
    Title: Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli.
  5. data reveal a role for Arrdc3 in the regulation of Ucp1 expression in adipocytes. However, this adipocyte effect is insufficient to generate the obesity-resistant phenotype of mice with ubiquitous deletion of Arrdc3, indicating a likely role for Arrdc3 in cells other than adipocytes
    Title: Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.
  6. In the course of breeding our own Arrdc3-deficient mice, we observed two novel phenotypes in homozygotes: skin abnormalities, and embryonic lethality on normal chow diet, but not on high fat diet.
    Title: Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.
  7. The obesity risk locus contains a single gene, arrestin domain-containing 3 (ARRDC3), which interacts directly with beta-adrenergic receptors and is gender-specific.
    Title: The arrestin domain-containing 3 protein regulates body mass and energy expenditure.
  8. Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins
    Title: Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC107410

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-3 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fat pad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of heat generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of heat generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arrestin domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042591.2 → NP_001036056.1  arrestin domain-containing protein 3

    See identical proteins and their annotated locations for NP_001036056.1

    Status: VALIDATED

    Source sequence(s)
    CT009711
    Consensus CDS
    CCDS36736.1
    UniProtKB/Swiss-Prot
    Q4KMN0, Q7TPQ9, Q80TE6, Q8K0L7
    UniProtKB/TrEMBL
    Q0GJK3
    Related
    ENSMUSP00000096957.3, ENSMUST00000099356.10
    Conserved Domains (2) summary
    smart01017
    Location:187 → 314
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:22 → 165
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. NR_153410.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009711
    Related
    ENSMUST00000159690.8

  2. NR_153411.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009711

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    81031508..81044161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247082.1 → XP_030102942.1  arrestin domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    E0CZE1
    Conserved Domains (1) summary
    smart01017
    Location:5 → 94
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain

  2. XM_030247081.1 → XP_030102941.1  arrestin domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    E0CZE1
    Related
    ENSMUSP00000125455.2, ENSMUST00000161441.2
    Conserved Domains (1) summary
    smart01017
    Location:5 → 94
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain

  3. XM_006517017.4 → XP_006517080.1  arrestin domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    smart01017
    Location:96 → 223
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:13 → 74
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178917.2: Suppressed sequence

    Description
    NM_178917.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPQ9.1 GenPept UniProtKB/Swiss-Prot:Q7TPQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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