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Iars1 isoleucyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 105148, updated on 5-Mar-2024

Summary

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Official Symbol
Iars1provided by MGI
Official Full Name
isoleucyl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:2145219
See related
Ensembl:ENSMUSG00000037851 AllianceGenome:MGI:2145219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ILRS; Iars; 2510016L12Rik; E430001P04Rik
Summary
Enables isoleucine-tRNA ligase activity. Involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 23.5), CNS E11.5 (RPKM 22.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 25.38 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49835606..49887743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49682130..49734267)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene STARR-positive B cell enhancer ABC_E8527 Neighboring gene nucleolar protein 8 Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene predicted gene, 23482 Neighboring gene sperm motility kinase X-like Neighboring gene predicted gene, 19334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Kim JY, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060739, Free PMC Article
  2. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  3. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  4. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
  5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables isoleucine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within isoleucyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
isoleucine--tRNA ligase, cytoplasmic
Names
IRS
ileRS
isoleucine-tRNA synthetase
isoleucyl-tRNA synthetase, cytoplasmic
NP_742012.2
XP_006516889.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172015.3 → NP_742012.2  isoleucine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_742012.2

    Status: VALIDATED

    Source sequence(s)
    AK133856, BB052629, BY139910
    Consensus CDS
    CCDS36659.1
    UniProtKB/Swiss-Prot
    Q6NXK4, Q8BU30
    Related
    ENSMUSP00000132082.2, ENSMUST00000165316.8
    Conserved Domains (1) summary
    PLN02882
    Location:6 → 1070
    PLN02882; aminoacyl-tRNA ligase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49835606..49887743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516826.3 → XP_006516889.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006516889.1

    UniProtKB/Swiss-Prot
    Q6NXK4, Q8BU30
    Conserved Domains (1) summary
    PLN02882
    Location:6 → 1070
    PLN02882; aminoacyl-tRNA ligase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU30.2 GenPept UniProtKB/Swiss-Prot:Q8BU30

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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