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Tecpr2 tectonin beta-propeller repeat containing 2 [ Mus musculus (house mouse) ]

Gene ID: 104859, updated on 5-Mar-2024

Summary

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Official Symbol
Tecpr2provided by MGI
Official Full Name
tectonin beta-propeller repeat containing 2provided by MGI
Primary source
MGI:MGI:2144865
See related
Ensembl:ENSMUSG00000021275 AllianceGenome:MGI:2144865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0297; 4930573I19Rik
Summary
Predicted to be involved in protein exit from endoplasmic reticulum. Predicted to be located in cytoplasm. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 49. Orthologous to human TECPR2 (tectonin beta-propeller repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 8.0), frontal lobe adult (RPKM 6.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 60.86 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110855681..110938828)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110889243..110972394)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 839 Neighboring gene mitochondrial pyruvate carrier 1, pseudogene Neighboring gene cyclin dependent kinase 2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1157 Neighboring gene ribosomal protein S19, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_33311 Neighboring gene ankyrin repeat domain 9 Neighboring gene predicted gene, 51959

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation. Tamim-Yecheskel BC, et al. Autophagy, 2021 Oct. PMID 33218264, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation.
    Title: A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein exit from endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tectonin beta-propeller repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081057.2 → NP_001074526.1  tectonin beta-propeller repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001074526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 both encode isoform 1.
    Source sequence(s)
    AC101875, AC153152
    Consensus CDS
    CCDS36562.1
    UniProtKB/TrEMBL
    B9EHS4, Q3UH45
    Related
    ENSMUSP00000126749.2, ENSMUST00000169597.9
    Conserved Domains (4) summary
    smart00706
    Location:1360 → 1392
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    COG2319
    Location:36 → 380
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:37 → 73
    7WD40; WD40 repeat [structural motif]
    pfam06462
    Location:1294 → 1322
    Hyd_WA; Propeller

  2. NM_001289510.1 → NP_001276439.1  tectonin beta-propeller repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001276439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode isoform 1.
    Source sequence(s)
    AK029810, AK147592, AW488496
    Consensus CDS
    CCDS36562.1
    UniProtKB/TrEMBL
    B9EHS4, Q3UH45
    Related
    ENSMUSP00000127949.2, ENSMUST00000165978.3
    Conserved Domains (4) summary
    smart00706
    Location:1360 → 1392
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    COG2319
    Location:36 → 380
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:37 → 73
    7WD40; WD40 repeat [structural motif]
    pfam06462
    Location:1294 → 1322
    Hyd_WA; Propeller

  3. NM_175336.3 → NP_780545.2  tectonin beta-propeller repeat-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_780545.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region that results in use of a downstream translation start. The encoded protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC101875, AK029810, AW488496, BC145250, CV557670
    UniProtKB/TrEMBL
    Q8CDN4
    Conserved Domains (2) summary
    smart00706
    Location:993 → 1025
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    pfam06462
    Location:927 → 955
    Hyd_WA; Propeller

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110855681..110938828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515352.4 → XP_006515415.1  tectonin beta-propeller repeat-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006515415.1

    UniProtKB/TrEMBL
    B9EHS4, Q3UH45
    Conserved Domains (4) summary
    smart00706
    Location:1360 → 1392
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    COG2319
    Location:36 → 380
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:37 → 73
    7WD40; WD40 repeat [structural motif]
    pfam06462
    Location:1294 → 1322
    Hyd_WA; Propeller

  2. XM_006515356.4 → XP_006515419.1  tectonin beta-propeller repeat-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006515419.1

    Conserved Domains (2) summary
    smart00706
    Location:993 → 1025
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    pfam06462
    Location:927 → 955
    Hyd_WA; Propeller

  3. XM_006515351.5 → XP_006515414.1  tectonin beta-propeller repeat-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006515414.1

    UniProtKB/TrEMBL
    B9EHS4, Q3UH45
    Conserved Domains (4) summary
    smart00706
    Location:1360 → 1392
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    COG2319
    Location:36 → 380
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:37 → 73
    7WD40; WD40 repeat [structural motif]
    pfam06462
    Location:1294 → 1322
    Hyd_WA; Propeller

  4. XM_006515353.5 → XP_006515416.1  tectonin beta-propeller repeat-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006515416.1

    UniProtKB/TrEMBL
    B9EHS4, Q3UH45
    Conserved Domains (4) summary
    smart00706
    Location:1360 → 1392
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    COG2319
    Location:36 → 380
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:37 → 73
    7WD40; WD40 repeat [structural motif]
    pfam06462
    Location:1294 → 1322
    Hyd_WA; Propeller

  5. XM_006515354.5 → XP_006515417.1  tectonin beta-propeller repeat-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    B9EHS4
    Conserved Domains (2) summary
    smart00706
    Location:1221 → 1253
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    pfam06462
    Location:1155 → 1183
    Hyd_WA; Propeller
Nucleotide Protein Strain
Heading Accession and Version

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