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Ptpn23 protein tyrosine phosphatase, non-receptor type 23 [ Mus musculus (house mouse) ]

Gene ID: 104831, updated on 11-Apr-2024

Summary

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Official Symbol
Ptpn23provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 23provided by MGI
Primary source
MGI:MGI:2144837
See related
Ensembl:ENSMUSG00000036057 AllianceGenome:MGI:2144837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTP-TD14
Summary
Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; positive regulation of adherens junction organization; and positive regulation of transport. Predicted to act upstream of or within cell projection organization and protein transport. Predicted to be located in ciliary basal body; early endosome; and nuclear body. Is expressed in several structures, including alimentary system; central nervous system; gonad; respiratory system epithelium; and skin. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 17.6), limb E14.5 (RPKM 12.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F2; 9 59.92 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110214152..110237278, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110385084..110408210, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tropomyosin beta chain pseudogene Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene STARR-seq mESC enhancer starr_25259 Neighboring gene SREBF chaperone Neighboring gene STARR-seq mESC enhancer starr_25260 Neighboring gene STARR-positive B cell enhancer ABC_E6807 Neighboring gene kelch-like 18 Neighboring gene neutrophilic granule protein Neighboring gene STARR-positive B cell enhancer ABC_E8318

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation. Ma H, et al. Cell Signal, 2015 Nov. PMID 26232618
  2. Role of ESCRT component HD-PTP/PTPN23 in cancer. Gingras MC, et al. Biochem Soc Trans, 2017 Jun 15. PMID 28620046
  3. Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. Manteghi S, et al. Cell Rep, 2016 May 31. PMID 27210750
  4. Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP). Gingras MC, et al. Int J Dev Biol, 2009. PMID 19378249
  5. A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. Andersen JN, et al. FASEB J, 2004 Jan. PMID 14718383

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
    Title: PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
  2. HD-PTP/PTPN23 as a prominent haploinsufficient tumor suppressor gene preventing tumor progression through control of integrin trafficking.
    Title: Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.
  3. The role of HD-PTP/PTPN23 in cancer and tumorigenesis is reviewed.
    Title: Role of ESCRT component HD-PTP/PTPN23 in cancer.
  4. HD-PTP affects the intracellular sorting of activated PDGFRbeta and the migration, proliferation and tumorigenicity of cells stimulated by PDGF.
    Title: Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation.
  5. PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR-142-3p plays an important role in the pathogenesis of testicular germ cell tumors.
    Title: Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.
  6. homozygous gene deletion is lethal around embryonic day 9.5, suggesting that Ptpn23 is an essential requirement for early stages of embryonic development
    Title: Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 23
NP_001074512.1
XP_011241233.1
XP_030099856.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081043.1 → NP_001074512.1  tyrosine-protein phosphatase non-receptor type 23

    See identical proteins and their annotated locations for NP_001074512.1

    Status: VALIDATED

    Source sequence(s)
    BC059902, BY008138, CA325506, CF538443, CF734421
    Consensus CDS
    CCDS40780.1
    UniProtKB/Swiss-Prot
    Q69ZJ0, Q6PB44, Q8R1Z5, Q923E6
    Related
    ENSMUSP00000039580.8, ENSMUST00000040021.12
    Conserved Domains (5) summary
    cd09234
    Location:362 → 702
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    cd09239
    Location:2 → 357
    BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    cd00047
    Location:1276 → 1505
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:1276 → 1506
    Y_phosphatase; Protein-tyrosine phosphatase
    pfam13949
    Location:417 → 703
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110214152..110237278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242931.3 → XP_011241233.1  tyrosine-protein phosphatase non-receptor type 23 isoform X2

    Conserved Domains (4) summary
    cd09234
    Location:169 → 509
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    PHA03247
    Location:540 → 946
    PHA03247; large tegument protein UL36; Provisional
    cd14539
    Location:1106 → 1310
    PTP-N23; PTP-like domain of tyrosine-protein phosphatase non-receptor type 23
    cl14649
    Location:1 → 164
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

  2. XM_030243996.2 → XP_030099856.1  tyrosine-protein phosphatase non-receptor type 23 isoform X1

    Conserved Domains (4) summary
    cd09234
    Location:279 → 619
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    PHA03247
    Location:650 → 1056
    PHA03247; large tegument protein UL36; Provisional
    cd14539
    Location:1216 → 1420
    PTP-N23; PTP-like domain of tyrosine-protein phosphatase non-receptor type 23
    cl14649
    Location:1 → 274
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PB44.2 GenPept UniProtKB/Swiss-Prot:Q6PB44

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